Ischemic Cardiomyopathy |
Classification and external resources |
ICD-10 |
I25.5 |
[edit on Wikidata]
|
Ischemic cardiomyopathy is a type of cardiomyopathy caused by a narrowing of the coronary arteries which supply blood to the heart.[1] Typically, patients with ischemic cardiomyopathy have a history of acute myocardial infarction,[2] however, it may occur in patients with coronary artery disease, but without a past history of acute myocardial infarction. This cardiomyopathy is one of the leading causes of sudden cardiac death.[3][3]
Contents
- 1 Cause
- 2 Pathophysiology
- 3 Diagnosis
- 4 Management
- 5 References
- 6 Further reading
Cause
Ischemic cardiomyopathy is the cause of more than 60% of all systolic heart failures in most countries of the world.[3][4] A chest radiography that demonstrates coronary artery calcification is a probable indication of ischemic cardiomyopathy.[5]
Among the causes for ischemic cardiomyopathy are:[6]
- Diabetes
- Atherosclerosis
- Vasospasm
- Inflammation of arteries
Pathophysiology
Ischemic cardiomyopathy is caused by a lack of oxygen due to a narrowing of coronary arteries, in turn causing cell death. This can cause different levels of tissue injury and affect large and intermediate arteries alike.[7][8][9]
Diagnosis
Ischemic cardiomyopathy can be diagnosed via magnetic resonance imaging (MRI) protocol, imaging both global and regional function. Also the Look-Locker technique is used to identify diffuse fibrosis; it is therefore important to be able to determine the extent of the ischemic scar.[10] Some argue that only left main- or proximal-left anterior descending artery disease is relevant to the diagnostic criteria for ischemic cardiomyopathy.[2] Myocardial imaging usually demonstrates left ventricular dilation, severe ventricular disfunction, and multiple infarctions.[11] Signs include congestive heart failure, angina edema, weight gain and fainting, among others.[3][12]
Management
Revascularization in patients with heart failure and significant coronary artery disease is strongly associated with improved survival, some research showing up to 75% survival rates over 5 years.[13][14] A stem cell study indicated that using autologous cardiac stem cells as a regenerative approach for (after myocardial infarction) the human heart has great potential.[15]
American Heart Association practice guidelines indicate (ICD) implantable cardioverter-defibrillator use in those with ischemic cardiomyopathy (40 days post-MI) that are (NYHA) New York Heart Association functional class I. LVEF of >30% is often used to differentiate primary from ischemic cardiomyopathy, and a prognosis indicator.[16][17] At the same time, patients who undergo ventricular restoration on top of coronary artery bypass show improved postoperative ejection fraction as compared to those treated with only coronary artery bypass surgery.[18] Severe cases are treated with heart transplantation.[19]
Prognosis
One of the most important features differentiating ischemic cardiomyopathy from the other forms of cardiomyopathy is the shortened, or worsened all-cause mortality in patients with ischemic cardiomyopathy. According to several studies, coronary artery bypass graft surgery has a survival advantage over medical therapy (for ischemic cardiomyopathy) across varied follow-ups.[8][20][21][22]
References
- ^ "Cardiomyopathy: MedlinePlus Medical Encyclopedia". www.nlm.nih.gov. Retrieved 2015-09-09.
- ^ a b Felker, G.Michael; Shaw, Linda K; O’Connor, Christopher M (January 2002). "A standardized definition of ischemic cardiomyopathy for use in clinical research". Journal of the American College of Cardiology 39 (2): 210–218. doi:10.1016/S0735-1097(01)01738-7.
- ^ a b c d Reynolds Delgado (21 April 2009). Interventional Treatment of Advanced Ischemic Heart Disease. Springer Science & Business Media. pp. 39–. ISBN 978-1-84800-395-8.
- ^ Griffin, Brian P. (2012-10-01). Manual of Cardiovascular Medicine. Lippincott Williams & Wilkins. p. 130. ISBN 9781451131604.
- ^ Brant, William E.; Helms, Clyde A. (2007-01-01). Fundamentals of Diagnostic Radiology. Lippincott Williams & Wilkins. p. 635. ISBN 9780781761352.
- ^ Bisognano, John D.; Baker, Marc L.; Earley, Mary Beth (2009-04-09). Manual of Heart Failure Management. Springer Science & Business Media. p. 50. ISBN 9781848821859.
- ^ Anversa, Piero; Sonnenblick, Edmund H. (1990). "Ischemic cardiomyopathy: Pathophysiologic mechanisms". Progress in Cardiovascular Diseases 33 (1): 49–70. doi:10.1016/0033-0620(90)90039-5. ISSN 0033-0620.
- ^ a b Yatteau, Ronald F.; Peter, Robert H.; Behar, Victor S.; Bartel, Alan G.; Rosati, Robert A.; Kong, Yihong (1974). "Ischemic cardiomyopathy: The myopathy of coronary artery disease". The American Journal of Cardiology 34 (5): 520–525. doi:10.1016/0002-9149(74)90121-0. ISSN 0002-9149.
- ^ Douglas L. Mann; Douglas P. Zipes; Peter Libby; Robert O. Bonow (30 July 2014). Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. Elsevier Health Sciences. pp. 1225–. ISBN 978-0-323-29064-7.
- ^ Hodler, Jurg (2015). Diseases of the Chest and Heart: Diagnostic Imaging and Interventional. Springer. p. 146. ISBN 978-88-470-5751-7. Retrieved 10 September 2015.
- ^ E. van der Wall; K.J. Lie (6 December 2012). Recent Views on Hypertrophic Cardiomyopathy. Springer Science & Business Media. pp. 43–. ISBN 978-94-009-4994-2.
- ^ Allen P. Burke; Fabio Tavora (8 November 2010). Practical Cardiovascular Pathology. Lippincott Williams & Wilkins. pp. 96–. ISBN 978-1-60547-841-8.
- ^ Luciani, Giovanni Battista; Montalbano, Giuseppe; Casali, Gianluca; Mazzucco, Alessandro (2000). "Predicting long-term functional results after myocardial revascularization in ischemic cardiomyopathy". The Journal of Thoracic and Cardiovascular Surgery 120 (3): 478–489. doi:10.1067/mtc.2000.108692. ISSN 0022-5223.
- ^ Falk, Erling; Shah, Prediman; Feyter, Pim de (2007-03-28). Ischemic Heart Disease. CRC Press. p. 226. ISBN 9781840765151.
- ^ Cai, Lu; Keller, Bradley B (2014-01-03). "Cardiac regeneration and diabetes". Regenerative Medicine Research 2 (1). doi:10.1186/2050-490X-2-1. ISSN 2050-490X. PMC 4422323. PMID 25984329.
- ^ Iskandrian, Abdulmassih S.; Helfeld, Hope; Lemlek, Joseph; Lee, Jaetae; Iskandrian, Basil; Heo, Jaekyeong (1992). "Differentiation between primary dilated cardiomyopathy and ischemic cardiomyopathy based on right ventricular performance". American Heart Journal 123 (3): 768–773. doi:10.1016/0002-8703(92)90518-Z. ISSN 0002-8703.
- ^ Hunt, S. A. (20 September 2005). "ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult--Summary Article: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): Developed in Collaboration With the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: Endorsed by the Heart Rhythm Society". Circulation 112 (12): 1825–1852. doi:10.1161/CIRCULATIONAHA.105.167587. Retrieved 10 September 2015.
- ^ Maxey, Thomas S; Reece, T.Brett; Ellman, Peter I; Butler, Paris D; Kern, John A; Tribble, Curtis G; Kron, Irving L (2004). "Coronary artery bypass with ventricular restoration is superior to coronary artery bypass alone in patients with ischemic cardiomyopathy". The Journal of Thoracic and Cardiovascular Surgery 127 (2): 428–434. doi:10.1016/j.jtcvs.2003.09.024. ISSN 0022-5223. PMID 14762351.
- ^ H. W. Louie, H. Laks, E. Milgalter, D. C. Jr Drinkwater, M. A. Hamilton, R. C. Brunken & L. W. Stevenson (November 1991). "Ischemic cardiomyopathy. Criteria for coronary revascularization and cardiac transplantation". Circulation 84 (5 Suppl): III290–III295. PMID 1934422.
- ^ O’Connor, Christopher M; Velazquez, Eric J; Gardner, Laura H; Smith, Peter K; Newman, Mark F; Landolfo, Kevin P; Lee, Kerry L; Califf, Robert M; Jones, Robert H (2002). "Comparison of coronary artery bypass grafting versus medical therapy on long-term outcome in patients with ischemic cardiomyopathy (a 25-year experience from the Duke Cardiovascular Disease Databank)". The American Journal of Cardiology 90 (2): 101–107. doi:10.1016/S0002-9149(02)02429-3. ISSN 0002-9149.
- ^ Velazquez, Eric J.; Williams, Judson B.; Yow, Eric; Shaw, Linda K.; Lee, Kerry L.; Phillips, Harry R.; O’Connor, Christopher M.; K.Smith, Peter; Jones, Robert H. (2012-02-01). "Long-term Survival of Patients with Ischemic Cardiomyopathy Treated by CABG versus Medical Therapy". The Annals of thoracic surgery 93 (2): 523–530. doi:10.1016/j.athoracsur.2011.10.064. ISSN 0003-4975. PMC 3638256. PMID 22269720.
- ^ Elefteriades, John A; Morales, David L.S; Gradel, Christophe; Tollis, George; Levi, Evelyn; Zaret, Barry L (1997). "Results of Coronary Artery Bypass Grafting by a Single Surgeon Patients With Left Ventricular Ejection Fractions ≤30%". The American Journal of Cardiology 79 (12): 1573–1578. doi:10.1016/S0002-9149(97)00201-4. ISSN 0002-9149.
Further reading
- Likoff, Mariell Jessup, Sheryl L. Chandler, and Harold R. Kay. "Clinical determinants of mortality in chronic congestive heart failure secondary to idiopathic dilated or to ischemic cardiomyopathy." The American journal of cardiology 59.6 (1987): 634-638.
- Carmeliet, Peter, et al. "Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188." Nature medicine 5.5 (1999): 495.
- Menasché, Philippe, et al. "The myoblast autologous grafting in ischemic cardiomyopathy (MAGIC) trial first randomized Placebo-controlled study of myoblast transplantation." circulation 117.9 (2008): 1189-1200.
- Beltrami, Carlo Alberto, et al. "Structural basis of end-stage failure in ischemic cardiomyopathy in humans." Circulation 89.1 (1994): 151-163.
Medicine
|
|
Specialties
and
subspecialties |
Surgery
|
|
- Cardiac surgery
- Cardiothoracic surgery
- Colorectal surgery
- Eye surgery
- General surgery
- Neurosurgery
- Oral and maxillofacial surgery
- Orthopedic surgery
- Hand surgery
- Otolaryngology (ENT)
- Pediatric surgery
- Plastic surgery
- Reproductive surgery
- Surgical oncology
- Thoracic surgery
- Transplant surgery
- Trauma surgery
- Urology
- Vascular surgery
|
Internal medicine
|
|
- Allergy / Immunology
- Angiology
- Cardiology
- Endocrinology
- Gastroenterology
- Geriatrics
- Hematology
- Hospital medicine
- Infectious disease
- Nephrology
- Oncology
- Pulmonology
- Rheumatology
|
Obstetrics and gynaecology
|
|
- Gynaecology
- Gynecologic oncology
- Maternal-fetal medicine
- Obstetrics
- Reproductive endocrinology and infertility
- Urogynecology
|
Diagnostic
|
|
- Radiology
- Interventional radiology, Nuclear medicine
- Pathology
- Anatomical pathology, Clinical pathology, Clinical chemistry, Clinical immunology, Cytopathology, Medical microbiology, Transfusion medicine
|
Specialties
|
|
- Addiction medicine
- Adolescent medicine
- Anesthesiology
- Dermatology
- Disaster medicine
- Diving medicine
- Emergency medicine
- Family medicine
- General practice
- Hospital medicine
- Intensive-care medicine
- Medical genetics
- Neurology
- Occupational medicine
- Ophthalmology
- Oral medicine
- Pain management
- Palliative care
- Pediatrics
- Physical medicine and rehabilitation
- Preventive medicine
- Psychiatry
- Radiation oncology
- Reproductive medicine
- Sexual medicine
- Sleep medicine
- Sports medicine
- Transplantation medicine
- Tropical medicine
- Venereology
|
|
|
Medical education |
- Medical school
- Bachelor of Medicine, Bachelor of Surgery
- Bachelor of Medical Sciences
- Master of Medicine
- Master of Surgery
- Doctor of Medicine
- Doctor of Osteopathic Medicine
- MD-PhD
|
|
Related topics |
- Allied health
- Nanomedicine
- Molecular oncology
- Personalized medicine
- Veterinary medicine
- Physician
- History of medicine
|
|
- Category
- Index
- Commons
- Portal
- WikiProject
- bookshelf
|
|
Cardiovascular disease I00–I52, 390–429
|
|
Ischaemic |
Coronary disease
|
- Coronary artery disease (CAD)
- Coronary artery aneurysm
- Coronary artery dissection
- Coronary thrombosis
- Coronary vasospasm
- Myocardial bridge
|
|
Active ischemia
|
- Angina pectoris
- Prinzmetal's angina
- Stable angina
- Acute coronary syndrome
- Myocardial infarction
- Unstable angina
|
|
Sequelae
|
- hours
- Hibernating myocardium
- Myocardial stunning
- days
- weeks
- Aneurysm of heart / Ventricular aneurysm
- Dressler syndrome
|
|
|
Layers |
Pericardium
|
- Pericarditis
- Acute
- Chronic / Constrictive
- Pericardial effusion
- Cardiac tamponade
- Hemopericardium
|
|
Myocardium
|
- Myocarditis
- Cardiomyopathy: Dilated (Alcoholic), Hypertrophic, and Restrictive
- Loeffler endocarditis
- Cardiac amyloidosis
- Endocardial fibroelastosis
- Arrhythmogenic right ventricular dysplasia
|
|
Endocardium /
valves
|
Endocarditis
|
- infective endocarditis
- Subacute bacterial endocarditis
- non-infective endocarditis
- Libman–Sacks endocarditis
- Nonbacterial thrombotic endocarditis
|
|
Valves
|
- mitral
- regurgitation
- prolapse
- stenosis
- aortic
- tricuspid
- pulmonary
|
|
|
|
Conduction /
arrhythmia |
Bradycardia
|
- Sinus bradycardia
- Sick sinus syndrome
- Heart block: Sinoatrial
- AV
- Intraventricular
- Bundle branch block
- Right
- Left
- Left anterior fascicle
- Left posterior fascicle
- Bifascicular
- Trifascicular
- Adams–Stokes syndrome
|
|
Tachycardia
(paroxysmal and sinus)
|
Supraventricular
|
- Atrial
- Junctional
- AV nodal reentrant
- Junctional ectopic
|
|
Ventricular
|
- Accelerated idioventricular rhythm
- Catecholaminergic polymorphic
- Torsades de pointes
|
|
|
Premature contraction
|
- Atrial
- Junctional
- Ventricular
|
|
Pre-excitation syndrome
|
- Lown–Ganong–Levine
- Wolff–Parkinson–White
|
|
Flutter / fibrillation
|
- Atrial flutter
- Ventricular flutter
- Atrial fibrillation
- Ventricular fibrillation
|
|
Pacemaker
|
- Ectopic pacemaker / Ectopic beat
- Multifocal atrial tachycardia
- Pacemaker syndrome
- Parasystole
- Wandering pacemaker
|
|
Long QT syndrome
|
- Andersen–Tawil
- Jervell and Lange-Nielsen
- Romano–Ward
|
|
Cardiac arrest
|
- Sudden cardiac death
- Asystole
- Pulseless electrical activity
- Sinoatrial arrest
|
|
Other / ungrouped
|
- hexaxial reference system
- Right axis deviation
- Left axis deviation
- QT
- T
- ST
- Osborn wave
- ST elevation
- ST depression
|
|
|
Cardiomegaly |
- Ventricular hypertrophy
- Left
- Right / Cor pulmonale
- Atrial enlargement
|
|
Other |
- Cardiac fibrosis
- Heart failure
- Diastolic heart failure
- Cardiac asthma
- Rheumatic fever
|
|
Index of the heart
|
|
Description |
- Anatomy
- Physiology
- Development
|
|
Disease |
- Injury
- Congenital
- Neoplasms and cancer
- Other
- Symptoms and signs
- Blood tests
|
|
Treatment |
- Procedures
- Drugs
- glycosides
- other stimulants
- antiarrhythmics
- vasodilators
|
|
|