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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/14 23:34:25」(JST)

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Iodocyanopindolol (INN) is a drug related to pindolol which acts as both a β₁ adrenoreceptor antagonist and a 5-HT_1A receptor antagonist. Its ¹²⁵I radiolabelled derivative has been widely used in mapping the distribution of beta adrenoreceptors in the body.^[1]

References

^ Brodde OE, Karad K, Zerkowski HR, Rohm N, Reidemeister JC (1983). "Coexistence of beta 1- and beta 2-adrenoceptors in human right atrium. Direct identification by (+/-)-[125I]iodocyanopindolol binding". Circulation Research 53 (6): 752–758. PMID 6139182.

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English Journal

Activation of cardiomyocytes depending on their proximity to human bone marrow stem cells.

Roeske F, Stein A, Salameh A, Rastan A, Ziegelhoeffer B, Garbade J, Misfeld M, Kostelka M, Mohr FW, Dhein S.SourceClinic for Cardiac Surgery, University of Leipzig, Leipzig, Germany.
The Thoracic and cardiovascular surgeon.Thorac Cardiovasc Surg.2011 Mar;59(2):78-84. Epub 2011 Mar 7.
Our study aimed to elucidate whether bone marrow stem cell (BMC) treatment might result in a cellular response in cardiomyocytes IN VITRO. Subconfluent neonatal rat cardiomyocyte cultures were cocultured for three days with Vybrant CM-DiI labeled BMC from human sternal bone marrow and underwent immu
PMID 21384303

Identification and characterization of β-adrenergic receptors in isolated primary equine tracheal epithelial cells.

Abraham G, Shibeshi W, Ungemach FR.SourceUniversity of Leipzig, Faculty of Veterinary Medicine, Institute of Pharmacology, Pharmacy and Toxicology, An den Tierkliniken 15, 04103 Leipzig, Germany. gabraham@rz.uni-leipzig.de
Pulmonary pharmacology & therapeutics.Pulm Pharmacol Ther.2011 Feb;24(1):174-81. Epub 2010 Jun 25.
Responses and functions of airway epithelial cells are stimulated by β?-agonists via the β?-adrenergic receptors (β?-ARs)-G(s)-protein-cAMP-system, thus, affecting airway inflammation such as in asthma and equine recurrent airway obstruction (RAO). Though horses can be used as large animal
PMID 20601048

Japanese Journal

Molecular Characterization of Pharmacological Properties and Selectivity of SWR-0315NA for β_3-Adrenoceptors (Pharmacology)

AHMED Maruf,HANAOKA Yoko,KISO Tatsuya,KAKITA Takao,OHTSUBO Yoshikazu,NAGATOMO Takafumi
Biological & pharmaceutical bulletin 27(5), 718-722, 2004-05-01
… In the radioligand binding studies of [^<125>I]iodocyanopindolol with COS-7 cell membranes that transiently expressed human β-adrenoceptor (β-AR) subtypes, SWR-0315NA exhibited 1-fold and 2-fold greater binding affinities for β_3-AR than those for β_1- and β_2-ARs, respectively. …
NAID 110003608839

気管支喘息児における末梢血単核細胞βアドレナリン受容体測定の意義 : 血中カテコラミン, β受容体とEIA, 有酸素作業能との関係について

久保田知樹,古賀一吉,荒木速雄,小田嶋博,西間三馨,宮本裕士,田中宏暁,進藤宗洋
アレルギー 49(1), 40-51, 2000-01-30
末梢血単核細胞上には肺組織と同様にβアドレナリン受容体が存在する.我々は気管支喘息児のカテコラミン分泌と有酸素作業能, EIA(exercise induced asthma)との関係(研究1), 及び安静時末梢血単核細胞βアドレナリン受容体数と有酸素作業能, EIA, 気道過敏性との関係(研究2)を検討した.(研究1)対象は入院中の気管支喘息児11名(男子9名, 女子2名, 年齢11?16歳)で …
NAID 110002425878

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リンク元	「ヨードシアノピンドロール」「ICYP」

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Iodocyanopindolol
Systematic (IUPAC) name
	(RS)-4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-3-iodo-1H-indole-2-carbonitrile
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	85124-14-7
ATC code	None
Chemical data
Formula	C16H20IN3O2
Mol. mass	413.25 g/mol
	SMILES IC1=C(C#N)NC2=CC=CC(OCC(CNC(C)(C)C)O)=C21;
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