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WordNet

lying between two extremes in time or space or state; "going from sitting to standing without intermediate pushes with the hands"; "intermediate stages in a process"; "intermediate stops on the route"; "an intermediate range plane"
a substance formed during a chemical process before the desired product is obtained
the amount per unit size (同)denseness
a conjugated protein having a lipid component; the principal means for transporting lipids in the blood

PrepTutorEJDIC

(程度・距離・時間などにおいて)中間の,中間にある(起こる)
〈U〉『密集』;『密度』,濃さ / 〈U〉〈C〉(物質の)密度,濃度,比重 / 〈U〉《話》頭の鈍さ,愚鈍さ

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/01 06:19:14」(JST)

wiki en

Intermediate-density lipoproteins (IDLs) belong to the lipoprotein particle family and are formed from the degradation of very low-density lipoproteins. IDL is one of the five major groups of lipoproteins (chylomicrons, VLDL, IDL, LDL, HDL) that enable fats and cholesterol to move within the water-based solution of the bloodstream. Each native IDL particle consists of protein that encircles various fatty acids, enabling, as a water-soluble particle, these fatty acids to travel in the aqueous blood environment as part of the fat transport system within the body. Their size is, in general, 25 to 35 nm in diameter, and they contain primarily a range of triacylglycerols and cholesterol esters. They are cleared from the plasma into the liver by receptor-mediated endocytosis, or further degraded to form LDL particles.

(Although one might intuitively assume that "intermediate-density" refers to a density between that of high-density and low-density lipoproteins, it in fact refers to a density between that of low-density and very-low-density lipoproteins. Lipoproteins are classified as less dense when the fat to protein ratio is increased.)

In general, IDL, somewhat similar to low-density lipoprotein (LDL), transports a variety of triglyceride fats and cholesterol and, like LDL, can also promote the growth of atheroma.

VLDL is a large, triglyceride-rich lipoprotein secreted by the liver that transports triglyceride to adipose tissue and muscle. The triglycerides in VLDL are removed in capillaries by the enzyme lipoprotein lipase, and the VLDL returns to the circulation as a smaller particle with a new name, intermediate-density lipoprotein (IDL). The IDL particles have lost most of their triglyceride, but they retain cholesteryl esters. Some of the IDL particles are rapidly taken up by the liver; others remain in circulation, where they undergo further triglyceride hydrolysis and are converted to LDL. A distinguishing feature of the IDL particle is their content of multiple copies of the receptor ligand ApoE in addition to a single copy of ApoB-100. The multiple copies of ApoE allow IDL to bind to the LDL receptor with a very high affinity. When IDL is converted to LDL, the ApoE leaves the particle and only the ApoB-100 remains. Thereafter, the affinity for the LDL receptor is much reduced.[1]

References

Brown MS and Goldstein JL (1986). A receptor-mediated pathway for cholesterol homeostasis. Science 232:34–47.

UpToDate Contents

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1. リポ蛋白の分類、代謝、およびアテローム性動脈硬化症における役割 lipoprotein classification metabolism and role in atherosclerosis
2. 甲状腺疾患における脂質異常 lipid abnormalities in thyroid disease
3. 脂質異常症の二次的原因 secondary causes of dyslipidemia
4. 血中脂質およびリポ蛋白の測定 measurement of blood lipids and lipoproteins
5. リポ蛋白糸球体症 lipoprotein glomerulopathy

English Journal

Proteomic profiles reveal age-related changes in coelomic fluid of sea urchin species with different life spans.

Bodnar A.SourceBermuda Institute of Ocean Sciences, St. George's GE 01, Bermuda. Electronic address: andrea.bodnar@bios.edu.
Experimental gerontology.Exp Gerontol.2013 May;48(5):525-30. doi: 10.1016/j.exger.2013.01.014. Epub 2013 Feb 8.
Sea urchins have a different life history from humans and traditional model organisms used to study the process of aging. Sea urchins grow indeterminately, reproduce throughout their life span and some species have been shown to exhibit negligible senescence with no increase in mortality rate at adv
PMID 23453931

Incremental diagnostic value of circulating pentraxin in patients with intermediate risk of coronary artery disease.

Haybar H, Assareh A, Ghotbi Y, Torabizadeh M, Bozorgmanesh M.SourcePrevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran 19395-4763, Iran; mr_bozorgmanesh@endocrine.ac.ir.
Heart (British Cardiac Society).Heart.2013 May;99(9):640-8. doi: 10.1136/heartjnl-2012-303560. Epub 2013 Mar 6.
OBJECTIVES: Pentraxins are a superfamily of multifunctional conserved proteins, some of which are components of the humoral arm of innate immunity and behave as functional ancestors of antibodies. They are divided into short (C reactive protein) and long pentraxins (pentraxin 3; PTX3). We investigat
PMID 23468517

ABCA1 Mediates Unfolding of Apolipoprotein AI N Terminus on the Cell Surface Before Lipidation and Release of Nascent High-Density Lipoprotein.

Wang S, Gulshan K, Brubaker G, Hazen SL, Smith JD.SourceDepartment of Cellular and Molecular Medicine, and Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland OH; and Department of Cardiology, the Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China.
Arteriosclerosis, thrombosis, and vascular biology.Arterioscler Thromb Vasc Biol.2013 Apr 4. [Epub ahead of print]
OBJECTIVE: To gain insight into the mechanism by which ABCA1 generates nascent high-density lipoprotein.Approach and Results-HEK293 cells were stably transfected with ABCA1 vectors, encoding wild type, and the W590S and C1477R Tangier disease mutation isoforms, along with the K939M ATP-binding domai
PMID 23559627

Japanese Journal

Cholesterol Levels of Six Fractionated Serum Lipoproteins and its Relevance to Coronary Heart Disease Risk Scores

Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 24(9), 928-939, 2017
NAID 130006038522

イオン交換高速液体クロマトグラフィー法を用いたホルスタイン種成乳牛におけるコレステロールリポ蛋白質分画の分析

ペット栄養学会誌 20(1), 30-38, 2017
NAID 130005634026

化学療法施行中に重症心筋梗塞を発症した後腹膜原発胚細胞腫の1例

泌尿器科紀要 = Acta urologica Japonica 62(9), 483-487, 2016-09
NAID 120005853235

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リンク元	「中間密度リポ蛋白」
拡張検索	「intermediate-density lipoprotein」
関連記事	「intermediate」「intermedia」「lipoprotein」「lipoproteins」

「中間密度リポ蛋白」

　　[★]

英: intermediate-density lipoprotein、IDL lipoprotein、intermediate density lipoprotein
同: 中間型リポ蛋白、中間型リポタンパク、中間密度リポタンパク、中間型リポ蛋白質、中間密度リポ蛋白質、中間型リポタンパク質、中間密度リポタンパク質

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中間型リポ蛋白 : 68 件
中間密度リポ蛋白 : 45 件
中間型リポタンパク : 27 件
中間密度リポタンパク : 20 件
中間型リポ蛋白質 : 4 件
中間密度リポ蛋白質 : 24 件
中間型リポタンパク質 : 11 件
中間密度リポタンパク質 : 45 件

「intermediate-density lipoprotein」

　　[★]

中間密度リポタンパク質、中密度リポタンパク質、中間密度リポ蛋白、中密度リポ蛋白

関: IDL lipoprotein

「intermediate」

　　[★]

n.

中間体、中間

adj.

中間の、中間部の、中等の、間性の

関: halfway、intermediary、intermediary body、intermedius、intersex、interstitial、interzonal、middle、moderate

「intermedia」

　　[★]

Prevotella intermedia、thalassemia intermedia

「lipoprotein」

　　[★] リポ蛋白 lipoprotein 　

「lipoproteins」