- 関
- IDL lipoprotein
WordNet
- lying between two extremes in time or space or state; "going from sitting to standing without intermediate pushes with the hands"; "intermediate stages in a process"; "intermediate stops on the route"; "an intermediate range plane"
- a substance formed during a chemical process before the desired product is obtained
- the amount per unit size (同)denseness
- a conjugated protein having a lipid component; the principal means for transporting lipids in the blood
PrepTutorEJDIC
- (程度・距離・時間などにおいて)中間の,中間にある(起こる)
- 〈U〉『密集』;『密度』,濃さ / 〈U〉〈C〉(物質の)密度,濃度,比重 / 〈U〉《話》頭の鈍さ,愚鈍さ
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/12/08 07:30:04」(JST)
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This article relies largely or entirely on a single source. Relevant discussion may be found on the talk page. Please help improve this article by introducing citations to additional sources. (October 2015)
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Intermediate-density lipoproteins (IDLs) belong to the lipoprotein particle family and are formed from the degradation of very low-density lipoproteins. IDL is one of the five major groups of lipoproteins (chylomicrons, VLDL, IDL, LDL, HDL) that enable fats and cholesterol to move within the water-based solution of the bloodstream. Each native IDL particle consists of protein that encircles various lipids, enabling, as a water-soluble particle, these lipids to travel in the aqueous blood environment as part of the fat transport system within the body. Their size is, in general, 25 to 35 nm in diameter, and they contain primarily a range of triacylglycerols and cholesterol esters. They are cleared from the plasma into the liver by receptor-mediated endocytosis, or further degraded to form LDL particles.
(Although one might intuitively assume that "intermediate-density" refers to a density between that of high-density and low-density lipoproteins, it in fact refers to a density between that of low-density and very-low-density lipoproteins.)
In general, IDL, somewhat similar to low-density lipoprotein (LDL), transports a variety of triglyceride fats and cholesterol and, like LDL, can also promote the growth of atheroma.[citation needed]
VLDL is a large, triglyceride-rich lipoprotein secreted by the liver that transports triglyceride to adipose tissue and muscle. The triglycerides in VLDL are removed in capillaries by the enzyme lipoprotein lipase, and the VLDL returns to the circulation as a smaller particle with a new name, intermediate-density lipoprotein (IDL). The IDL particles have lost most of their triglyceride, but they retain cholesteryl esters. Some of the IDL particles are rapidly taken up by the liver; others remain in circulation, where they undergo further triglyceride hydrolysis and are converted to LDL. A distinguishing feature of the IDL particle is their content of multiple copies of the receptor ligand ApoE in addition to a single copy of ApoB-100. The multiple copies of ApoE allow IDL to bind to the LDL receptor with a very high affinity. When IDL is converted to LDL, the ApoE leaves the particle and only the ApoB-100 remains. Thereafter, the affinity for the LDL receptor is much reduced.
References
- Brown MS and Goldstein JL (1986). A receptor-mediated pathway for cholesterol homeostasis. Science 232:34–47.
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Lipids: lipoprotein particle metabolism
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| Lipoprotein particle classes and subclasses |
- delivery of TGs: Chylomicron
- VLDL
- delivery of C and CE: IDL
- LDL
- lb LDL
- sd LDL
- Lp(a)
- HDL
- Remnant cholesterol
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| Apolipoproteins |
- APOA
- APOB
- APOC
- APOD
- APOE
- APOH
- SAA
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| Extracellular enzymes |
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| Lipid transfer proteins |
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| Cell surface receptors |
- IDL: LRP
- LRP1
- LRP1B
- LRP2
- LRP3
- LRP4
- LRP5
- LRP5L
- LRP6
- LRP8
- LRP10
- LRP11
- LRP12
- LDL: LDLR
- LRPAP1
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| ATP-binding cassette transporter |
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UpToDate Contents
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English Journal
- Low rate of production of apolipoproteins b100 and AI in 2 patients with anderson disease (chylomicron retention disease).
- Ouguerram K, Zaïr Y, Kasbi-Chadli F, Nazih H, Bligny D, Schmitz J, Aparicio T, Chétiveaux M, Magot T, Aggerbeck LP, Samson-Bouma ME, Krempf M.SourceClinique d'Endocrinologie, Maladies Métaboliques, Nutrition, Hôpital Laennec, 44093 Nantes, Cedex 1, France. michel.krempf@univ-nantes.fr.
- Arteriosclerosis, thrombosis, and vascular biology.Arterioscler Thromb Vasc Biol.2012 Jun;32(6):1520-5. Epub 2012 Mar 22.
- OBJECTIVE: Anderson disease is a rare inherited lipid malabsorption syndrome associated with hypocholesterolemia and linked to SAR1B mutations. The aim of this article was to analyze the mechanisms responsible for the low plasma apolipoprotein Apo-B100 and Apo-AI in 2 patients with Anderson disease.
- PMID 22441101
- Relative importance of different lipid risk factors for the development of myocardial infarction at a very young age (≤ 40 years of age).
- Goliasch G, Oravec S, Blessberger H, Dostal E, Hoke M, Wojta J, Schillinger M, Huber K, Maurer G, Wiesbauer F.SourceDepartment of Internal Medicine II, Medical University of Vienna, Vienna, Austria Department of Internal Medicine II, University of Bratislava, Bratislava, Slovakia Krankenanstalten Dr Dostal, Vienna, Austria 3rd Department of Internal Medicine, Cardiology and Emergency Medicine, Wilhelminen Hospital, Vienna, Austria.
- European journal of clinical investigation.Eur J Clin Invest.2012 Jun;42(6):631-6. doi: 10.1111/j.1365-2362.2011.02629.x. Epub 2011 Dec 8.
- Eur J Clin Invest 2012; 42 (6): 631-636 ABSTRACT: Background Low-density lipoprotein (LDL) cholesterol lowering has been established as one of the principal targets in preventive cardiology. Recently, assessment of LDL particle size and number as well as other lipid moieties has been presented as
- PMID 22150092
Japanese Journal
- Cholesterol Levels of Six Fractionated Serum Lipoproteins and its Relevance to Coronary Heart Disease Risk Scores
- イオン交換高速液体クロマトグラフィー法を用いたホルスタイン種成乳牛におけるコレステロールリポ蛋白質分画の分析
- 家族性Ⅲ型高脂血症 (特集 高トリグリセライド血症 : 高トリグリセライド血症の最新知見) -- (高トリグリセライド血症 : 病因・病態および管理法)
Related Links
- Intermediate-density lipoproteins belong to the lipoprotein particle family and are formed from the degradation of very low-density lipoproteins. IDL is one of the five major groups of lipoproteins (chylomicrons, VLDL, IDL, LDL, HDL) that ...
- Definition of intermediate density lipoprotein (IDL) in the Medical Dictionary. intermediate density lipoprotein (IDL) explanation. Information about intermediate density lipoprotein (IDL) in Free online English dictionary. What is ...
★リンクテーブル★
[★]
- 英
- intermediate-density lipoprotein、IDL lipoprotein、intermediate density lipoprotein
- 同
- 中間型リポ蛋白、中間型リポタンパク、中間密度リポタンパク、中間型リポ蛋白質、中間密度リポ蛋白質、中間型リポタンパク質、中間密度リポタンパク質
[show details]
[★]
- 英
- intermediate-density lipoprotein、IDL lipoprotein
- 関
- IDLリポタンパク質、IDLリポ蛋白、中密度リポタンパク質、中密度リポ蛋白、中間密度リポ蛋白
[★]
- 英
- intermediate-density lipoprotein
- 関
- 中間密度リポタンパク質、中密度リポタンパク質、中間密度リポ蛋白
[★]
- 英
- intermediate-density lipoprotein
- 関
- 中間密度リポタンパク質、中密度リポ蛋白、中間密度リポ蛋白
[★]
- 英
- intermediate-density lipoprotein
- 関
- 中間密度リポタンパク
[★]
- 関
- halfway、intermediary、intermediary body、intermedius、intersex、interstitial、interzonal、middle、moderate
[★]
[★]
リポ蛋白 lipoprotein
[★]
リポ蛋白 lipoprotein