インターフェロン受容体、インターフェロンレセプター

WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
an antiviral protein produced by cells that have been invaded by a virus; inhibits replication of the virus

PrepTutorEJDIC

=sense organ / 受信装置
インターフェロン(ウイルス増殖抑制物質)
インターフェロン (virusの増殖を抑制する)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/08/23 21:00:18」(JST)

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Type II cytokine receptors are transmembrane proteins that are expressed on the surface of certain cells, which bind and respond to a select group of cytokines. These receptors are similar to type I cytokine receptors except they do not possess the signature sequence WSXWS that is characteristic of type I receptors.

Structure

Typically type II cytokine receptors are heterodimers or multimers with a high and a low affinity component. Currently no complete structure of the extracellular domains of a type II cytokine receptor is available. These receptors are related predominantly by sequence similarities in their extracellular portions that are composed of tandem Ig-like domains. The intracellular domain of type II cytokine receptors is typically associated with a tyrosine kinase belonging to the Janus kinase (JAK) family.

Types

Type II cytokine receptors include those that bind type I and type II interferons, and those that bind members of the interleukin-10 family (interleukin-10, interleukin-20 and interleukin-22).^[1]^[2]

Interferon receptors

The interferon receptor is a molecule displayed on the surface of cells which allows them to interact with the anti-viral substance interferon. The receptor is genetically coded for by number of different genes, as there are a few distinct types of interferon. Interferon receptor deficiency is a condition showing some amenability to genetic therapy.^[3]

interferon-alpha/beta receptor
interferon-gamma receptor

Interleukin receptors

Interleukin-10 receptor
Interleukin-20 receptor
Interleukin-22 receptor
Interleukin-28 receptor

References

^ Dumoutier L, Lejeune D, Hor S, Fickenscher H, Renauld JC (2003). "Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3". Biochem. J. 370 (Pt 2): 391–6. doi:10.1042/BJ20021935. PMC 1223207. PMID 12521379.
^ Xu W, Presnell SR, Parrish-Novak J et al. (2001). "A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9511–6. doi:10.1073/pnas.171303198. PMC 55483. PMID 11481447.
^ Reuter U, Roesler J, Thiede C, Schulz A, Classen CF, Oelschlagel U, Debatin KM, Friedrich W (2002). "Correction of complete interferon-gamma receptor 1 deficiency by bone marrow transplantation". Blood 100 (12): 4234–5. doi:10.1182/blood-2002-02-0433. PMID 12393576.

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English Journal

Upregulation of miR-155 in CD4(+) T Cells Promoted Th1 Bias in Patients With Unstable Angina.

Chen Y1, Li L1, Lu Y1, Su Q1, Sun Y1, Liu Y1, Yang D1.
Journal of cellular physiology.J Cell Physiol.2015 Oct;230(10):2498-509. doi: 10.1002/jcp.24987.
An imbalance between T helper 1 (Th1) and T helper 2 (Th2) cells has been reported to increase plaque instability in patients with unstable angina (UA). MicroRNAs play a vital role in the differentiation of CD4(+) T cells. However, the role of microRNAs in regulation of Th1/Th2 balance in UA remains
PMID 25760478

Role of Toll like receptor 4 signaling pathway in the secondary damage induced by experimental spinal cord injury.

Impellizzeri D1, Ahmad A1, Di Paola R1, Campolo M1, Navarra M2, Esposito E1, Cuzzocrea S3.
Immunobiology.Immunobiology.2015 Sep;220(9):1039-49. doi: 10.1016/j.imbio.2015.05.013. Epub 2015 May 11.
Toll-like receptors (TLRs) are signaling receptors in the innate immune system that is specific immunologic response to systemic bacterial infection and injury. TLRs contribute to the initial induction of neuroinflammation in the CNS. In spinal cord injury (SCI) intricate immune cell interactions ar
PMID 25990044

TLR2/6 agonists and interferon-gamma induce human melanoma cells to produce CXCL10.

Mauldin IS1, Wang E2, Deacon DH1, Olson WC1, Bao Y3, Slingluff CL Jr1.
International journal of cancer. Journal international du cancer.Int J Cancer.2015 Sep;137(6):1386-96. doi: 10.1002/ijc.29515. Epub 2015 May 29.
Clinical approaches to treat advanced melanoma include immune therapies, whose benefits depend on tumor-reactive T-cell infiltration of metastases. However, most tumors lack significant immune infiltration prior to therapy. Selected chemokines promote T-cell migration into tumors; thus, agents that
PMID 25765738

Japanese Journal

Adjuvant effect of an alternative plasticizer, diisopropyl adipate, on a contact hypersensitivity mouse model: link with sensory ion channel TRPA1 activation

, , , , , , , ,
Biological and Pharmaceutical Bulletin advpub(0), 2015
… We have demonstrated that phthalate esters stimulate transient receptor potential ankyrin 1 (TRPA1) cation channels expressed on sensory neurons. … DBP and DIA were similarly active in the enhancement of interferon-γ production by draining lymph nodes, but the effect on interleukin-4 production was weaker with DIA. …
NAID 130005068107

表皮角化細胞死を伴う苔癬反応（Lichenoid tissue reaction）/Interface dermatitisを呈する皮膚粘膜疾患とマウスモデル

沖山奈緒子
日本臨床免疫学会会誌 38(1), 1-7, 2015
… erythematosus: LE）・皮膚筋炎・混合性結合織病の皮疹や骨髄移植患者の急性移植片対宿主病のような自己免疫疾患から，中毒性皮膚壊死症・Stevens-Johnson症候群のような薬疹まで多岐に渡る．主な病態は，Interferon-γやFasLを介した，CD8 T細胞による角化細胞アポトーシスの誘導であり，形質細胞様樹状細胞の関与も報告された．病態解析のために様々なマウスモデルが作られ，その代表的なものは，角化細胞膜上に卵白 …
NAID 130004875948

ISG15 Regulates RANKL-Induced Osteoclastogenic Differentiation of RAW264 Cells

, , [他], ,
Biological and Pharmaceutical Bulletin 38(3), 482-486, 2015
… Interferon-stimulated gene 15 kDa (ISG15) is a protein upregulated by interferon-β that negatively regulates osteoclastogenesis. … We investigated the role of ISG15 in receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenic differentiation of murine RAW264 cells. …
NAID 130004872278