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an optically inactive alcohol that is a component of the vitamin B complex

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/11 04:34:15」(JST)

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Inositol nicotinate is a vasodilator.

Inositol Nicotinate is given the term Inositol hexaniacinate, as well as "No-Flush Niacin".^[1] "Flushing", in physiology, is a broad term that essentially means that epidermal tissues have become reddened, such as when the skin is irritated from the histamine responses related to an allergic reaction, or from recent physical exercise, or even from anger or embarrassment. The reaction has been related to well over 200 causes.^[2] This form of niacin is supposed to reduce or prevent flushing by being broken down into the metabolites Niacin (aka Nicotinic acid) and Inositol at a slower rate.^[1]

References

^ ^a ^b Reza Taheri, PharmD "No-Flush Niacin for the Treatment of Hyperlipidemia" Medscape.com. Retrieved 2010-09-14. Originally Posted 2003-01-15.
^ Page Content attributed to webmaster and various authors. "Causes of Flushing" Wrongdiagnosis.com. Retrieved 2010-09-14. OP: Not applicable.

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English Journal

Biotransformation and pharmacokinetics of inositol hexanicotinate in rats.

Milton SG1, Robinson K, Ma J, Wei B, Poon IO, Liang D.
Xenobiotica; the fate of foreign compounds in biological systems.Xenobiotica.2013 Sep;43(9):817-22. doi: 10.3109/00498254.2012.762591. Epub 2013 Jan 24.
Inositol hexanicotinate (IHN) is an ester of the anti-hyperlipidemic drug nicotinic acid (NA). This study assessed the hydrolysis rate of IHN in human and rat plasma, and pharmacokinetics of the drug using a rat animal model. IHN (10 or 50 µg/mL) was incubated in plasma at 37 °C for 72 h. Ki
PMID 23347001

Wax-matrix extended-release niacin vs inositol hexanicotinate: a comparison of wax-matrix, extended-release niacin to inositol hexanicotinate "no-flush" niacin in persons with mild to moderate dyslipidemia.

Keenan JM1.
Journal of clinical lipidology.J Clin Lipidol.2013 Jan-Feb;7(1):14-23. doi: 10.1016/j.jacl.2012.10.004. Epub 2012 Oct 30.
BACKGROUND: Nicotinic acid (NA), long used for the treatment of dyslipidemia, has shown problems with undesirable side effects and safety issues. Wax-matrix, extended-release niacin (WMER) and inositol hexanicotinate (IHN) have both been formulated to increase patient tolerability. Several trials of
PMID 23351578

A systematic review of xuezhikang, an extract from red yeast rice, for coronary heart disease complicated by dyslipidemia.

Shang Q1, Liu Z, Chen K, Xu H, Liu J.
Evidence-based complementary and alternative medicine : eCAM.Evid Based Complement Alternat Med.2012;2012:636547. doi: 10.1155/2012/636547. Epub 2012 Apr 12.
Objective. This systematic review aims to evaluate the benefit and side effect of Xuezhikang for coronary heart disease (CHD) complicated by dyslipidemia. Methods. All randomized clinical trials (RCTs) with Xuezhikang as a treatment for CHD combined with dyslipidemia were considered for inclusion. D
PMID 22567033

Japanese Journal

Characterization of a Flavinogenic Mutant of Methanol Yeast Candida boidinii and Its Extracellular Secretion of Riboflavin

Suryadi Herman,Yoshida Nobuyuki,Yamada-Onodera Keiko [他],KATSURAGI TOHORU,TANI YOSHIKI
Journal of bioscience and bioengineering 90(1), 52-56, 2000-07-25
… The mutant was smaller than the wild type, did not grow on a minimal medium, and required L-tryptophan, L-leucine, inositol, and nicotinate for growth. …
NAID 110002684611

Characterization of a Flavinogenic Mutant of Methanol Yeast Cahdida boidinii and Its Extracellular Secretion of Riboflavin.

, , , ,
Journal of Bioscience and Bioengineering 90(1), 52-56, 2000
… The mutant was smaller than the wild type, did not grow on a minimal medium, and required L−tryptophan, L−leucine, inositol, and nicotinate for growth. …
NAID 130004145044

Protective Effects of Various Drugs on Adriamycin (Doxorubicin)-Induced Toxicity and Microsomal Lipid Peroxidation in Mice and Rats

篠沢真哉,五味田裕,荒木泰典
Biological and Pharmaceutical Bulletin 16(11), 1114-1117, 1993-11-15
… (Co Q), 235% for dextran sulfate (DS), 123% for dipyridamole, 121% for flavin adenine dinucleotide, 213% for reduced glutathion, 155% for inositol nicotinate, 157% for nicardipin and 297% for nicomol. …
NAID 110003663257

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関連記事	「inositol」「nicotinate」

「inositol」

Inositol nicotinate
Systematic (IUPAC) name
	cyclohexane-1,2,3,4,5,6-hexayl hexanicotinate
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Registry Number	6556-11-2
ATC code	C04AC03
PubChem	CID: 3720
ChemSpider	16736141
UNII	A99MK953KZ
KEGG	D01813
Chemical data
Formula	C42H30N6O12
Molecular mass	810.72 g/mol
	SMILES O=C(O[C@H]6[C@H](OC(=O)c1cccnc1)[C@H](OC(=O)c2cccnc2)[C@H](OC(=O)c3cccnc3)[C@@H](OC(=O)c4cccnc4)[C@@H]6OC(=O)c5cccnc5)c7cccnc7 ;