UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 不安症状および不安障害に対する補完代替療法：漢方薬および栄養補助食品complementary and alternative treatments for anxiety symptoms and disorders herbs and medications [show details]
…treatment with inositol may be efficacious for panic disorder, agoraphobia, and OCD: Panic disorder – A clinical trial with a crossover design compared adjunctive treatment with inositol to placebo… protective effect against free oxygen radicals (FOR) and lipid peroxidation (a biomarker for stress-induced oxidative cellular damage).…
2. 成人における低ナトリウム血症および高ナトリウム血症の症状 manifestations of hyponatremia and hypernatremia in adults [show details]
… requires both a reduction in the synthesis of new sodium-inositol cotransporters and the activation of a specific inositol efflux mechanism in the cell membrane .… percent (the remaining 7 percent is due to proteins and lipids with a small contribution from dissolved solutes)…
3. ペリツェウス・メルツバッハー病pelizaeus merzbacher disease [show details]
… Disruption of these functions results in impaired lipid-lipid, lipid-protein,… metabolite abnormalities, with a reduced choline level and increased levels of creatinine, glutamine, and inositol as well as NAA . Further study is needed to determine the clinical utility of MRS for the diagnosis…
4. T細胞受容体シグナル伝達t cell receptor signaling [show details]
…membrane phosphatidylinositol (PtdIns) lipids, phosphorylating the 3' position hydroxyl group of the inositol ring. Generation of 3'-phosphorylated-inositol lipids in the plasma membrane can create binding …
5. 血小板生物学platelet biology [show details]
…begins when phospholipase C cleaves membrane phosphatidylinositol 4,5-bisphosphate (PIP2) to form inositol 1,4,5-trisphosphate (IP3) and diacylglycerol, both of which serve as second messengers The eicosanoid … PKC has been identified as the cellular receptor for the lipid second messenger diacylglycerol (DAG),…

English Journal

Effects of a moderate iron overload and its interaction with yacon flour, and/or phytate, in the diet on liver antioxidant enzymes and hepatocyte apoptosis in rats.

Cocato ML, Lobo AR, Azevedo-Martins AK, Filho JM, de Sá LRM, Colli C.
Food chemistry. 2019 Jul;285()171-179.
The effect of moderate Fe overload in the diet and its interaction with phytate, and/or yacon flour (YF), recognized as an inhibitor, and facilitator, of Fe absorption, respectively, was evaluated in healthy rats. For this purpose the following parameters were analyzed: (1) apparent iron (Fe), coppe
PMID 30797332

Attenuation of calmodulin regulation evokes Ca oscillations: evidence for the involvement of intracellular arachidonate-activated channels and connexons.

Turovsky EA, Zinchenko VP, Kaimachnikov NP.
Molecular and cellular biochemistry. 2019 Jun;456(1-2)191-204.
Intracellular Са controls its own level by regulation of Ca transport across the plasma and organellar membranes, often acting via calmodulin (CaM). Drugs antagonizing CaM action induce an increase in cytosolic Ca concentration in different cells. We have found persistent Са oscillations in cult
PMID 30756222

Class 1 PI3K Clinical Candidates and Recent Inhibitor Design Strategies: A Medicinal Chemistry Perspective.

Garces AE, Stocks MJ.
Journal of medicinal chemistry. 2019 May;62(10)4815-4850.
Phosphatidylinositol 3-kinases (PI3Ks) are a family of lipid kinases that phosphorylate the 3-OH of the inositol ring of phosphoinositides, and deregulation of this pathway has implications in many diseases. The search for novel PI3K inhibitors has been at the forefront of academic and industrial me
PMID 30582807

Japanese Journal

Inositol Depletion Restores Vesicle Transport in Yeast Phospholipid Flippase Mutants

Yamagami Kanako,Yamamoto Takaharu,Sakai Shota,Mioka Tetsuo,Sano Takamitsu,Igarashi Yasuyuki,Tanaka Kazuma
Plos one 10(3), e0120108, 2015-03-17
… In eukaryotic cells, type 4 P-type ATPases function as phospholipid flippases, which translocate phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of the lipid bilayer. … Consistent with a previous report that Art5p downregulates the inositol transporter Itr1p by endocytosis, we found that flippase mutations were also suppressed by the disruption of ITR1, as well as by depletion of inositol from the culture medium. …
NAID 120005606034

Modulation of Signal Transduction and Gene Expression by Vitamin E via PI3Kγ/PKB and hTAP1/SEC14L2-Mediated Lipid Exchange

ZINGG Jean-Marc
Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ 61(Supplement), S76-S77, 2015
… Alternatively, the observed signalling may reflect specific interactions of vitamin E with enzymes, structural proteins, and transcription factors and/or result from vitamin E-induced alterations of physical and structural properties of membrane lipid domains in which it is embedded. …
NAID 130005109864

TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P2

Nobuaki Takahashi,Sayaka Hamada-Nakahara,Yuzuru Itoh,Kazuhiro Takemura,Atsushi Shimada,Yoshifumi Ueda,Manabu Kitamata,Rei Matsuoka,Kyoko Hanawa-Suetsugu,Yosuke Senju,Masayuki X. Mori,Shigeki Kiyonaka,Daisuke Kohda,Akio Kitao,Yasuo Mori,Shiro Suetsugu
2014-09-26
… The crystal structure of the TRPV4 ARD in complex with inositol-1,4,5-trisphosphate, the head-group of PI(4,5)P2, and the molecular-dynamics simulations revealed the PI(4,5)P2-binding amino-acid residues. … These findings identify TRPV4 ARD as a lipid-binding domain in which interactions with PI(4,5)P2 normalize the channel activity in TRPV4. …
NAID 120005716848