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1. 成人の嚥下障害の評価法approach to the evaluation of dysphagia in adults [show details]
…variable. Both infectious esophagitis and medication-induced esophagitis commonly present with dysphagia accompanied by painful swallowing. Patients with infectious esophagitis, especially due to …
2. 食道の単純ヘルペスウイルス感染herpes simplex virus infection of the esophagus [show details]
…resulting from chemotherapy, transplantation, or HIV infection. The most common causes of infectious esophagitis include candida, cytomegalovirus (CMV), and herpes simplex virus (HSV). This topic will address …
3. 口腔咽頭および食道カンジダ症の臨床症状clinical manifestations of oropharyngeal and esophageal candidiasis [show details]
4. 薬剤誘導性食道炎medication induced esophagitis [show details]
5. 全身性エリテマトーデスの消化器症状gastrointestinal manifestations of systemic lupus erythematosus [show details]
…or vasculitic changes to Auerbach plexus . Patients with lupus are at increased risk of infectious esophagitis (eg, Candida, cytomegalovirus, herpes simplex) due to immunosuppression. In addition, esophagitis…

English Journal

The Salivary Microbiome Is Altered in Children With Eosinophilic Esophagitis and Correlates With Disease Activity.

Hiremath G, Shilts MH, Boone HH, Correa H, Acra S, Tovchigrechko A, Rajagopala SV, Das SR.
Clinical and translational gastroenterology. 2019 May;().
Eosinophilic esophagitis (EoE) is an allergen-mediated inflammatory disease affecting the esophagus. Although microbial communities may affect the host immune responses, little is known about the role of the microbiome in EoE. We compared the composition of the salivary microbiome in children with E
PMID 31107724

Development and Application of a Functional Human Esophageal Mucosa Explant Platform to Eosinophilic Esophagitis.

Kurten RC, Rawson R, Shoda T, Duong LD, Adejumobi D, Levy R, Newbury RO, Rothenberg ME, Akuthota P, Wright BL, Dohil R, Jones SM, Aceves SS.
Scientific reports. 2019 Apr;9(1)6206.
There is an increasing prevalence of esophageal diseases but intact human tissue platforms to study esophageal function, disease mechanisms, and the interactions between cell types in situ are lacking. To address this, we utilized full thickness human donor esophagi to create and validate the ex viv
PMID 30996235

Single-cell RNA sequencing identifies inflammatory tissue T cells in eosinophilic esophagitis.

Wen T, Aronow BJ, Rochman Y, Rochman M, Kc K, Dexheimer PJ, Putnam P, Mukkada V, Foote H, Rehn K, Darko S, Douek D, Rothenberg ME.
The Journal of clinical investigation. 2019 Apr;130()2014-2028.
T cell heterogeneity is highly relevant to allergic disorders. We resolved the heterogeneity of human tissue CD3+ T cells during allergic inflammation, focusing on a tissue-specific allergic disease, eosinophilic esophagitis (EoE). We investigated 1088 single T cells derived from patients with a spe
PMID 30958799

NIMURA Satoshi,ISHIBASHI Hideki,KAYASHIMA Yoshiyuki,WATANABE Takashi,NAKAMURA Mamoru,KAWAKAMI Masahiro,KOBA Ikuro,SAKISAKA Shotaro,NABESHIMA Kazuki,TAKESHITA Morishige
福岡大学医学紀要 = Medical bulletin of Fukuoka University 44(2), 59-68, 2017-09
NAID 120006353649

髙橋亜由美,芝剛,吉村真一郎,前田真治,三木直樹,山中忠太郎,南部光彦
天理医学紀要 18(1), 31-35, 2015
症例は9歳女児．ノロウイルス感染後，嘔吐が続いたため外来受診した．2か月で6kgの体重減少が認められたため，精査加療目的で入院した．上部消化管造影では食道の拡張はなく，食道，胃，十二指腸の蠕動は良かったが，食道から胃への通過遅延がみられた．検査結果から食道アカラシアの疑いは強くはなかったが，下部食道括約筋圧が高い可能性があったため，食道アカラシアの薬物治療であるニトログリセリン舌下錠を …
NAID 130005085465

村瀬正敏,田中優作,龍華庸光 [他],森本康嗣,鈴木純,山田努,田實麻智子,福井彩子,永井純子,梅村臣吾,山川文子,山家由子,村瀬孝司
糖尿病 57(10), 783-790, 2014
症例は46歳男性．1ヶ月前より腰痛，2日前より心窩部の違和感が出現し，入院当日朝よりコーヒー残渣様の嘔吐を繰り返したため当院救急搬送．上部消化管内視鏡検査で急性壊死性食道炎と診断し入院加療．採血でHbA1c 13.3 %と未治療の糖尿病を認めた．発熱，炎症反応上昇を認め抗菌薬治療を開始．入院後の検査でメチシリン耐性黄色ブドウ球菌（MRSA）敗血症，感染性心内膜炎，化膿性椎体炎と硬膜外膿瘍が判明した …
NAID 130004706112