インドメタシンファルネシル
- 関
- indometacin、indometacin farnesil、indometacin sodium、indomethacin、indomethacin sodium
WordNet
- a nonsteroidal anti-inflammatory drug (trade name Indocin) (同)Indocin
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/12/01 10:43:20」(JST)
[Wiki en表示]
Indometacin farnesil
|
Systematic (IUPAC) name |
(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
|
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Legal status |
|
Routes of
administration |
Oral |
Pharmacokinetic data |
Metabolism |
To indometacin |
Biological half-life |
1.5 hours |
Excretion |
Renal |
Identifiers |
CAS Number |
85801-02-1 Y |
ATC code |
None |
PubChem |
CID: 5282183 |
ChemSpider |
4445378 Y |
Chemical data |
Formula |
C34H40ClNO4 |
Molecular mass |
562.14 g/mol |
SMILES
-
CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)OCC=C(C)CCC=C(C)CCC=C(C)C
|
InChI
-
InChI=1S/C34H40ClNO4/c1-23(2)9-7-10-24(3)11-8-12-25(4)19-20-40-33(37)22-30-26(5)36(32-18-17-29(39-6)21-31(30)32)34(38)27-13-15-28(35)16-14-27/h9,11,13-19,21H,7-8,10,12,20,22H2,1-6H3/b24-11+,25-19+ Y
-
Key:CFIGYZZVJNJVDQ-LMJOQDENSA-N Y
|
Y (what is this?) (verify) |
Indometacin farnesil (INN) is a prodrug of the non-steroidal anti-inflammatory drug indometacin, designed to reduce the occurrence of side-effects by esterification of the carboxyl group on indometacin with farnesol. Indometacin farnesil was first approved in Japan in 1991, and is available in Japan and Indonesia, under the trade names Infree and Dialon respectively.
External links
- Infree prescribing information from Eisai Co.
Prostanoid signaling
|
|
Receptor
(ligands) |
|
|
Enzyme
(inhibitors) |
Cyclooxygenase |
|
|
PGD2 synthase |
- Retinoids
- Selenium (selenium tetrachloride, sodium selenite, selenium disulfide)
|
|
PGE synthase |
HQL-79
|
|
PGF synthase |
Bimatoprost
|
|
PGI2 synthase |
Tranylcypromine
|
|
TXA synthase |
- Camonagrel
- Dazmegrel
- Dazoxiben
- Furegrelate
- Isbogrel
- Midazogrel
- Nafagrel
- Nicogrelate
- Ozagrel
- Picotamide
- Pirmagrel
- Ridogrel
- Rolafagrel
- Samixogrel
- Terbogrel
- U63557A
|
|
|
Others |
- Precursors: Linoleic acid
- γ-Linolenic acid (gamolenic acid)
- Dihomo-γ-linolenic acid
- Diacylglycerol
- Arachidonic acid
- Prostaglandin G2
- Prostaglandin H2
|
|
See also: Leukotrienergics
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Pseudogout of the acromioclavicular joint: report of two cases and review of the literature.
- Hakozaki M1, Kikuchi S, Otani K, Tajino T, Konno S.
- Modern rheumatology / the Japan Rheumatism Association.Mod Rheumatol.2011 Aug;21(4):440-3. doi: 10.1007/s10165-011-0417-8. Epub 2011 Feb 5.
- Although calcium pyrophosphate dehydrate (CPPD) deposition disease, including pseudogout, is a relatively common disease affecting the major joints, especially the knee, pseudogout in the acromioclavicular (AC) joint is very uncommon. We describe two cases of acute pseudogout attacks of the AC joint
- PMID 21298395
- Keishikajutsubuto (Guizhi-shu-fu-tang) treatment for refractory accumulation of synovial fluid in a patient with pustulotic arthro-osteitis.
- Satoh K1, Takano S, Kobayashi T.
- Fukushima journal of medical science.Fukushima J Med Sci.2007 Jun;53(1):33-8.
- We present a patient, a sixty-seven-year-old woman, who had refractory accumulation of synovial fluid in the knee joints with pustulotic arthro-osteitis for more than 10 years. Fifty ml of synovial fluid from her right knee contained 6,480 pg/ml of interleukin-8 (IL-8) and 15,000/mm3 of neutorophils
- PMID 17957964
- Successful treatment of primary Sjögren's syndrome with chronic natural killer lymphocytosis by high-dose prednisolone and indomethacin farnesil.
- Fujita Y1, Fujii T, Takeda N, Tanaka M, Mimori T.
- Internal medicine (Tokyo, Japan).Intern Med.2007;46(5):251-4. Epub 2007 Mar 1.
- We report a patient with Sjögren's syndrome and chronic natural killer lymphocytosis, who developed severe neutropenia, autoimmune hemolytic anemia, and immune thrombocytopenia. High-dose prednisolone therapy improved the hemolytic anemia and thrombocytopenia, but not the CD16(+) CD56(-) NK lymphoc
- PMID 17329922
Japanese Journal
- Keishikajutsubuto (Guizhi-shu-fu-tang) treatment for refractory accumulation of synovial fluid in a patient with pustulotic arthro-osteitis
- 佐藤 弘一郎,高野 静子,小林 利男
- Fukushima journal of medical science 53(1), 33-38, 2007-06-01
- … At first, she was treated with 400 mg/day of indomethacin farnesil (a prodrug that is converted to indomethacin after intestinal absorption) for 24 weeks. … Our data showed that Keishikajutsubuto might be suitable for this patient to regulate synovial fluid volume, reduce IL-8 concentration in synovial fluid, and block neutrophils migration to synovial fluid compared to indomethacin therapy. …
- NAID 10026160146
- KEISHIKAJUTSUBUTO (GUIZHI-SHU-FU-TANG) TREATMENT FOR REFRACTORY ACCUMULATION OF SYNOVIAL FLUID IN A PATIENT WITH PUSTULOTIC ARTHRO-OSTEITIS
- SATOH KOICHIRO,TAKANO SHIZUKO,KOBAYASHI TOSHIO
- FUKUSHIMA JOURNAL OF MEDICAL SCIENCE 53(1), 33-38, 2007
- … At first, she was treated with 400 mg/day of indomethacin farnesil (a prodrug that is converted to indomethacin after intestinal absorption) for 24 weeks. … Our data showed that Keishikajutsubuto might be suitable for this patient to regulate synovial fluid volume, reduce IL-8 concentration in synovial fluid, and block neutrophils migration to synovial fluid compared to indomethacin therapy. …
- NAID 130003387091
- Successful Treatment of Primary Sjoegren's Syndrome with Chronic Natural Killer Lymphocytosis by High-Dose Prednisolone and Indomethacin Farnesil
- Fujita Yoshimasa,Fujii Takao,Takeda Naho,Tanaka Masao,Mimori Tsuneyo
- Internal Medicine 46(5), 251-254, 2007
- … Interestingly, indomethacin farnesil (a prodrug of indomethacin) was effective for myalgia and also decreased the number of CD16+ CD56- NK cells. … NK lymphocytosis is rarely associated with autoimmune disease, but the combination of indomethacin and steroid therapy may have a favorable effect for such patients. …
- NAID 130000078560
Related Links
- Indomethacin farnesil (CAS NO.: 85801-02-1), with other name of 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 3,7,11-trimethyl-2,6,10-dodecatrienyl ester, could be produced through many synthetic method ... ...
- In the [examination] Chronic bad stomach, liver and kidneys of poor people who will tell a doctor. May exacerbate symptoms by disease. Please keep reported asthma and allergies are also physicians. Pregnant man, please tell ...
Related Pictures
![C19H16ClNO4 357.79](https://1mg.info/0/d/l/1676.jpg)
![Indomethacin farnesil – Wikipedia](https://1mg.info/0/d/l/1677.jpg)
![Prifelone - Wikipedia, the free](https://1mg.info/0/d/l/1678.jpg)
![Safety & Documentation](https://1mg.info/0/d/l/1679.jpg)
![53-86-1 Indomethacin](https://1mg.info/0/d/l/1680.jpg)
★リンクテーブル★
[★]
インドメタシンファルネシル
- 関
- indometacin、indometacin sodium、indomethacin、indomethacin farnesil、indomethacin sodium
[★]
インドメタシンナトリウム
- 関
- indometacin、indometacin farnesil、indomethacin、indomethacin farnesil、indomethacin sodium
[★]
インドメタシンナトリウム
- 関
- indometacin、indometacin farnesil、indometacin sodium、indomethacin、indomethacin farnesil
[★]
- 英
- indomethacin farnesil、indometacin farnesil
- 商
- インフリー
- 関
- インドメタシン