関: indometacin、indometacin sodium、indomethacin、indomethacin farnesil、indomethacin sodium

WordNet

a nonsteroidal anti-inflammatory drug (trade name Indocin) (同)Indocin

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/06 00:28:00」(JST)

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Indometacin farnesil (INN) is a prodrug of the non-steroidal anti-inflammatory drug indometacin, designed to reduce the occurrence of side-effects by esterification of the carboxyl group on indometacin with farnesol. Indometacin farnesil was first approved in Japan in 1991, and is available in Japan and Indonesia, under the trade names Infree and Dialon respectively.

External links

Infree prescribing information from Eisai Co.

This drug article relating to the musculoskeletal system is a stub. You can help Wikipedia by expanding it.

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English Journal

Pseudogout of the acromioclavicular joint: report of two cases and review of the literature.

Hakozaki M1, Kikuchi S, Otani K, Tajino T, Konno S.
Modern rheumatology / the Japan Rheumatism Association.Mod Rheumatol.2011 Aug;21(4):440-3. doi: 10.1007/s10165-011-0417-8. Epub 2011 Feb 5.
Although calcium pyrophosphate dehydrate (CPPD) deposition disease, including pseudogout, is a relatively common disease affecting the major joints, especially the knee, pseudogout in the acromioclavicular (AC) joint is very uncommon. We describe two cases of acute pseudogout attacks of the AC joint
PMID 21298395

Keishikajutsubuto (Guizhi-shu-fu-tang) treatment for refractory accumulation of synovial fluid in a patient with pustulotic arthro-osteitis.

Satoh K1, Takano S, Kobayashi T.
Fukushima journal of medical science.Fukushima J Med Sci.2007 Jun;53(1):33-8.
We present a patient, a sixty-seven-year-old woman, who had refractory accumulation of synovial fluid in the knee joints with pustulotic arthro-osteitis for more than 10 years. Fifty ml of synovial fluid from her right knee contained 6,480 pg/ml of interleukin-8 (IL-8) and 15,000/mm3 of neutorophils
PMID 17957964

Successful treatment of primary Sjögren's syndrome with chronic natural killer lymphocytosis by high-dose prednisolone and indomethacin farnesil.

Fujita Y1, Fujii T, Takeda N, Tanaka M, Mimori T.
Internal medicine (Tokyo, Japan).Intern Med.2007;46(5):251-4. Epub 2007 Mar 1.
We report a patient with Sjögren's syndrome and chronic natural killer lymphocytosis, who developed severe neutropenia, autoimmune hemolytic anemia, and immune thrombocytopenia. High-dose prednisolone therapy improved the hemolytic anemia and thrombocytopenia, but not the CD16(+) CD56(-) NK lymphoc
PMID 17329922

Japanese Journal

非ステロイド系抗炎症剤が原因と考えられた大腸穿孔の１例

日本臨床外科学会雑誌 65(2), 424-428, 2004
NAID 130003604012

人工関節素材を用いた各種粉体による炎症反応に対するインドメタシンファルネシルの効果

炎症 : 日本炎症学会雑誌 : Japanese journal of inflammation 19(3), 151-155, 1999-05-31
NAID 10009360097

人工関節素材を用いた各種粉体による炎症反応に対するインドメタシンファルネシルの効果

炎症 19(3), 151-155, 1999
NAID 130003856514

「indometacin sodium」

Indometacin farnesil
Systematic (IUPAC) name
	(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral
Pharmacokinetic data
Metabolism	To indometacin
Half-life	1.5 hours
Excretion	Renal
Identifiers
CAS number	85801-02-1
ATC code	None
PubChem	CID 5282183
ChemSpider	4445378
Chemical data
Formula	C34H40ClNO4
Mol. mass	562.14 g/mol
	SMILES CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)OCC=C(C)CCC=C(C)CCC=C(C)C;
	InChI InChI=1S/C34H40ClNO4/c1-23(2)9-7-10-24(3)11-8-12-25(4)19-20-40-33(37)22-30-26(5)36(32-18-17-29(39-6)21-31(30)32)34(38)27-13-15-28(35)16-14-27/h9,11,13-19,21H,7-8,10,12,20,22H2,1-6H3/b24-11+,25-19+ ; Key:CFIGYZZVJNJVDQ-LMJOQDENSA-N ;
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