インドメタシンファルネシル
- 関
- indometacin、indometacin sodium、indomethacin、indomethacin farnesil、indomethacin sodium
WordNet
- a nonsteroidal anti-inflammatory drug (trade name Indocin) (同)Indocin
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/01/06 00:28:00」(JST)
[Wiki en表示]
Indometacin farnesil
|
Systematic (IUPAC) name |
(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate |
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Pregnancy cat. |
? |
Legal status |
℞ Prescription only |
Routes |
Oral |
Pharmacokinetic data |
Metabolism |
To indometacin |
Half-life |
1.5 hours |
Excretion |
Renal |
Identifiers |
CAS number |
85801-02-1 |
ATC code |
None |
PubChem |
CID 5282183 |
ChemSpider |
4445378 Y |
Chemical data |
Formula |
C34H40ClNO4 |
Mol. mass |
562.14 g/mol |
SMILES
- CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)OCC=C(C)CCC=C(C)CCC=C(C)C
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InChI
-
InChI=1S/C34H40ClNO4/c1-23(2)9-7-10-24(3)11-8-12-25(4)19-20-40-33(37)22-30-26(5)36(32-18-17-29(39-6)21-31(30)32)34(38)27-13-15-28(35)16-14-27/h9,11,13-19,21H,7-8,10,12,20,22H2,1-6H3/b24-11+,25-19+ Y
Key:CFIGYZZVJNJVDQ-LMJOQDENSA-N Y
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Y (what is this?) (verify)
|
Indometacin farnesil (INN) is a prodrug of the non-steroidal anti-inflammatory drug indometacin, designed to reduce the occurrence of side-effects by esterification of the carboxyl group on indometacin with farnesol. Indometacin farnesil was first approved in Japan in 1991, and is available in Japan and Indonesia, under the trade names Infree and Dialon respectively.
External links
- Infree prescribing information from Eisai Co.
UpToDate Contents
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English Journal
- Pseudogout of the acromioclavicular joint: report of two cases and review of the literature.
- Hakozaki M1, Kikuchi S, Otani K, Tajino T, Konno S.
- Modern rheumatology / the Japan Rheumatism Association.Mod Rheumatol.2011 Aug;21(4):440-3. doi: 10.1007/s10165-011-0417-8. Epub 2011 Feb 5.
- Although calcium pyrophosphate dehydrate (CPPD) deposition disease, including pseudogout, is a relatively common disease affecting the major joints, especially the knee, pseudogout in the acromioclavicular (AC) joint is very uncommon. We describe two cases of acute pseudogout attacks of the AC joint
- PMID 21298395
- Keishikajutsubuto (Guizhi-shu-fu-tang) treatment for refractory accumulation of synovial fluid in a patient with pustulotic arthro-osteitis.
- Satoh K1, Takano S, Kobayashi T.
- Fukushima journal of medical science.Fukushima J Med Sci.2007 Jun;53(1):33-8.
- We present a patient, a sixty-seven-year-old woman, who had refractory accumulation of synovial fluid in the knee joints with pustulotic arthro-osteitis for more than 10 years. Fifty ml of synovial fluid from her right knee contained 6,480 pg/ml of interleukin-8 (IL-8) and 15,000/mm3 of neutorophils
- PMID 17957964
- Successful treatment of primary Sjögren's syndrome with chronic natural killer lymphocytosis by high-dose prednisolone and indomethacin farnesil.
- Fujita Y1, Fujii T, Takeda N, Tanaka M, Mimori T.
- Internal medicine (Tokyo, Japan).Intern Med.2007;46(5):251-4. Epub 2007 Mar 1.
- We report a patient with Sjögren's syndrome and chronic natural killer lymphocytosis, who developed severe neutropenia, autoimmune hemolytic anemia, and immune thrombocytopenia. High-dose prednisolone therapy improved the hemolytic anemia and thrombocytopenia, but not the CD16(+) CD56(-) NK lymphoc
- PMID 17329922
Japanese Journal
- 非ステロイド系抗炎症剤が原因と考えられた大腸穿孔の1例
- 人工関節素材を用いた各種粉体による炎症反応に対するインドメタシンファルネシルの効果
- 炎症 : 日本炎症学会雑誌 : Japanese journal of inflammation 19(3), 151-155, 1999-05-31
- NAID 10009360097
- 人工関節素材を用いた各種粉体による炎症反応に対するインドメタシンファルネシルの効果
Related Links
- Links Share new link Ulcerogenicity and effect on inhibition of prostaglandin generation of ... shared by scpof Influence of indometacin farnesil on blood coagulation. Comparison ... shared by Cowboy1993 Enzymatic hydrolysis of ...
- Indometacin Farnesil is a medicine available in a number of countries worldwide. A list of US medications equivalent to Indometacin Farnesil is available on the Drugs.com website. ... Important Notice: The Drugs.com international ...
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インドメタシンナトリウム
- 関
- indometacin、indometacin farnesil、indomethacin、indomethacin farnesil、indomethacin sodium
[★]
インドメタシンファルネシル
- 関
- indometacin、indometacin farnesil、indometacin sodium、indomethacin、indomethacin sodium
[★]
インドメタシンナトリウム
- 関
- indometacin、indometacin farnesil、indometacin sodium、indomethacin、indomethacin farnesil
[★]
- 英
- indomethacin farnesil、indometacin farnesil
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- インフリー
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- インドメタシン