WordNet

a determining or causal element or factor; "education is an important determinant of ones outlook on life" (同)determiner, determinative, determining factor, causal factor
a square matrix used to solve simultaneous equations

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1. 急性リウマチ熱の疫学および病因 epidemiology and pathogenesis of acute rheumatic fever
2. ペニシリンの皮膚試験 penicillin skin testing
3. 糸球体の免疫障害の機序 mechanisms of immune injury of the glomerulus
4. 免疫正常患者における単純ヘルペスウイルス1型感染の防止 prevention of herpes simplex virus type 1 infection in immunocompetent patients
5. 原発性胆汁性肝硬変の病因 pathogenesis of primary biliary cirrhosis

An extensive antigenic footprint underpins immunodominant TCR adaptability against a hypervariable viral determinant.

Nivarthi UK1, Gras S2, Kjer-Nielsen L1, Berry R3, Lucet IS3, Miles JJ4, Tracy SL5, Purcell AW6, Bowden DS5, Hellard M7, Rossjohn J8, McCluskey J9, Bharadwaj M9.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2014 Dec 1;193(11):5402-13. doi: 10.4049/jimmunol.1401357. Epub 2014 Oct 29.
Mutations in T cell epitopes are implicated in hepatitis C virus (HCV) persistence and can impinge on vaccine development. We recently demonstrated a narrow bias in the human TCR repertoire targeted at an immunodominant, but highly mutable, HLA-B*0801-restricted epitope ((1395)HSKKKCDEL(1403) [HSK])
PMID 25355921

Modification of the hepatitis B virus envelope protein glycosylation pattern interferes with secretion of viral particles, infectivity, and susceptibility to neutralizing antibodies.

Julithe R1, Abou-Jaoudé G1, Sureau C2.
Journal of virology.J Virol.2014 Aug;88(16):9049-59. doi: 10.1128/JVI.01161-14. Epub 2014 Jun 4.
The envelope proteins of hepatitis B virus (HBV) bear an N-linked glycosylation site at N146 within the immunodominant a-determinant in the antigenic loop (AGL) region. This glycosylation site is never fully functional, leading to a nearly 1/1 ratio of glycosylated/nonglycosylated isoforms in the vi
PMID 24899172

The classical lancefield antigen of group a Streptococcus is a virulence determinant with implications for vaccine design.

van Sorge NM1, Cole JN2, Kuipers K3, Henningham A2, Aziz RK4, Kasirer-Friede A5, Lin L3, Berends ET6, Davies MR7, Dougan G8, Zhang F9, Dahesh S3, Shaw L3, Gin J10, Cunningham M11, Merriman JA12, Hütter J13, Lepenies B13, Rooijakkers SH6, Malley R9, Walker MJ14, Shattil SJ5, Schlievert PM12, Choudhury B15, Nizet V16.
Cell host & microbe.Cell Host Microbe.2014 Jun 11;15(6):729-40. doi: 10.1016/j.chom.2014.05.009.
Group A Streptococcus (GAS) is a leading cause of infection-related mortality in humans. All GAS serotypes express the Lancefield group A carbohydrate (GAC), comprising a polyrhamnose backbone with an immunodominant N-acetylglucosamine (GlcNAc) side chain, which is the basis of rapid diagnostic test
PMID 24922575

Identification of an immunodominant type-II collagen peptide recognized by T cells in H-2q mice : self tolerance at the level of determinant selection