UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 混合性結合組織病における抗U1-RNP抗体 anti u1 rnp antibodies in mixed connective tissue disease
2. 若年性特発性関節炎：疫学と免疫病態学 juvenile idiopathic arthritis epidemiology and immunopathogenesis
3. 原発性胆汁性胆管炎（原発性胆汁性肝硬変）の病因 pathogenesis of primary biliary cholangitis primary biliary cirrhosis
4. 抗リボゾームP蛋白抗体 antiribosomal p protein antibodies
5. 再発性多発性軟骨炎の病因および発症機序 etiology and pathogenesis of relapsing polychondritis

English Journal

Cross-immunogenicity: antibodies to infliximab in Remicade-treated patients with IBD similarly recognise the biosimilar Remsima.

Ben-Horin S1, Yavzori M1, Benhar I2, Fudim E1, Picard O1, Ungar B1, Lee S3, Kim S3, Eliakim R1, Chowers Y4.
Gut.Gut.2016 Jul;65(7):1132-8. doi: 10.1136/gutjnl-2015-309290. Epub 2015 Apr 20.
OBJECTIVE: The cross-immunogenicity of the recently approved infliximab-biosimilar Remsima (CT-P13) with the originator drug Remicade is still unknown.DESIGN: Sera of patients with IBD with or without measurable anti-Remicade antibodies to infliximab (ATI) were tested for their cross-reactivity to t
PMID 25897019

Designing an efficient multi-epitope peptide vaccine against Vibrio cholerae via combined immunoinformatics and protein interaction based approaches.

Nezafat N1, Karimi Z2, Eslami M1, Mohkam M2, Zandian S1, Ghasemi Y3.
Computational biology and chemistry.Comput Biol Chem.2016 Jun;62:82-95. doi: 10.1016/j.compbiolchem.2016.04.006. Epub 2016 Apr 19.
Cholera continues to be a major global health concern. Among different Vibrio cholerae strains, only O1 and O139 cause acute diarrheal diseases that are related to epidemic and pandemic outbreaks. The currently available cholera vaccines are mainly lived and attenuated vaccines consisting of V. chol
PMID 27107181

Cui Z1, Zhao MH2, Jia XY1, Wang M1, Hu SY1, Wang SX1, Yu F1, Brown KL3, Hudson BG4, Pedchenko V3.
Journal of autoimmunity.J Autoimmun.2016 Jun;70:1-11. doi: 10.1016/j.jaut.2016.04.001. Epub 2016 Apr 23.
Autoantibody against glomerular basement membrane (GBM) plays a direct role in the initiation and development of Goodpasture's (GP) disease. The principal autoantigen is the non-collagenous domain 1 (NC1) of α3 chain of collagen IV, with two immunodominant epitopes, EA-α3 and EB-α3. We recently d
PMID 27117167

Development of a Novel In Silico Docking Simulation Model for the Fine HIV-1 Cytotoxic T Lymphocyte Epitope Mapping

Mori Masahiko,Matsuki Kei,Maekawa Tomoyuki,Tanaka Mari,Sriwanthana Busarawan,Yokoyama Masaru,Ariyoshi Koya
PLoS ONE 7(7), e41703, 2012-07-27
… Introduction: Class I HLA's polymorphism has hampered CTL epitope mapping with laborious experiments. … Materials and Methods: We have developed a novel in silico epitope prediction method, based on HLA crystal structure and a peptide docking simulation model, calculating the peptide-HLA binding affinity at four amino acid residues in each terminal. … We also found a significant reduction in epitope detection rates for longer epitopes in HLArestrictor (p = 0.027), but not in the novel model. …
NAID 120005052723

Different In Vivo Effects of HIV-1 Immunodominant Epitope-Specific Cytotoxic T Lymphocytes on Selection of Escape Mutant Viruses

Hirokazu Koizumi,Masao Hashimoto,Mamoru Fujiwara,Hayato Murakoshi,Takayuki Chikata,Mohamed Ali Borghan,Atsuko Hachiya,Yuka Kawashima,Hiroshi Takata,Takamasa Ueno,Shinichi Oka,Masafumi Takiguchi,コイズミヒロカズ,ハシモトマサオ,フジワラマモル,ムラコシハヤト,ハチヤアツコ,カワシマユカ,タカタヒロシ,ウエノタカマサ,オカシンイチ,タキグチマサフミ,小泉寛和,端本昌夫,藤原守,村越勇人,蜂谷敦子,川島夕佳,高田比呂志,上野貴将,岡慎一,滝口雅文
Journal of Virology 84(11), 5508-5519, 2010-06
… Therefore, we first investigated the correlation between the ability of HLA-A*1101-restricted CTLs recognizing immunodominant epitopes in vitro and the selection of escape mutants. … Ex vivo analysis of these CTLs revealed that the latter CTLs had a significantly stronger ability to recognize the epitope than the former ones. …
NAID 120002696399