Chemistry (Weinheim an der Bergstrasse, Germany).Chemistry.2015 Jul 13;21(29):10513-21. doi: 10.1002/chem.201501249. Epub 2015 Jun 10.
Sugar function, structure and dynamics are intricately correlated. Ring flexibility is intrinsically related to biological activity; actually plasticity in L-iduronic rings modulates their interactions with biological receptors. However, the access to the experimental values of the energy barriers a
Heparosan-glucuronate 5-epimerase: Molecular cloning and characterization of a novel enzyme.
Mochizuki H1, Yamagishi K2, Suzuki K2, Kim YS3, Kimata K4.
Glycobiology.Glycobiology.2015 Jul;25(7):735-44. doi: 10.1093/glycob/cwv013. Epub 2015 Feb 12.
Iduronic acid (IdoA) is a critical component of heparan sulfate in its interaction with functional proteins. Heparosan-N-sulfate-glucuronate 5-epimerase (HNSG-5epi) converts d-glucuronic acid (GlcA) residues in N-sulfated heparosan (NS-heparosan), as an intermediate in heparan sulfate biosynthesis,
Matrix biology : journal of the International Society for Matrix Biology.Matrix Biol.2015 Jun 23. pii: S0945-053X(15)00122-5. doi: 10.1016/j.matbio.2015.06.004. [Epub ahead of print]
One of the key regulators of endochondral ossification is Indian hedgehog (Ihh), which acts as a long-range morphogen in the developing skeletal elements. Previous studies have shown that the distribution and signaling activity of Ihh is regulated by the concentration of the extracellular glucosamin
Dermatan sulfate epimerase 2 is the predominant isozyme in the formation of the chondroitin sulfate/dermatan sulfate hybrid structure in postnatal developing mouse brain