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English Journal

Uncovering the Relationship between Sulphation Patterns and Conformation of Iduronic Acid in Heparan Sulphate.

Hsieh PH1, Thieker DF2, Guerrini M3, Woods RJ2, Liu J1.
Scientific reports.Sci Rep.2016 Jul 14;6:29602. doi: 10.1038/srep29602.
The L-iduronic acid (IdoA) residue is a critically important structural component in heparan sulphate polysaccharide for the biological functions. The pyranose ring of IdoA is present in (1)C4-chair, (2)SO-skew boat, and less frequently, in (4)C1-chair conformations. Here, we analyzed the conformati
PMID 27412370

Coulson-Thomas VJ1.
International journal of experimental pathology.Int J Exp Pathol.2016 Jul 6. doi: 10.1111/iep.12180. [Epub ahead of print]
Heparan sulphate (HS) is ubiquitously expressed and is formed of repeating glucosamine and glucuronic/iduronic acid units which are generally highly sulphated. HS is found in tissues bound to proteins forming HS proteoglycans (HSPGs) which are present on the cell membrane or in the extracellular mat
PMID 27385054

Piperigkou Z1,2, Mohr B1, Karamanos N2, Götte M3.
Cell and tissue research.Cell Tissue Res.2016 Jul 1. [Epub ahead of print]
Cancer cell behavior is not only governed by tumor cell-autonomous properties but also by the surrounding tumor stroma. Cancer-associated fibroblasts, blood vessels, immune cells and the extracellular matrix of the tumor microenvironment have a profound influence on tumor progression. Proteoglycans
PMID 27365088