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1. 続発性無月経の評価およびマネージメントevaluation and management of secondary amenorrhea [show details]
…functional hypothalamic amenorrhea)? Is the woman taking any drugs that might cause or be associated with amenorrhea? The drug may be taken for a systemic illness that itself can cause hypothalamic amenorrhea …
2. 小児における先天性中枢性低換気症候群および睡眠関連低換気症のその他の原因congenital central hypoventilation syndrome and other causes of sleep related hypoventilation in children [show details]
…syndrome (CCHS), late onset central hypoventilation syndrome (LO-CHS), or rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) syndrome. These disorders will …
3. 成人における二次性および三次性副腎不全の原因causes of secondary and tertiary adrenal insufficiency in adults [show details]
…the hypothalamic-pituitary-adrenal axis) by intercurrent stress, and mixed agonist-antagonist properties . Regardless of the mechanism, clinicians should be alert to the possibility of hypothalamic-pituitary-adrenal …
4. クッシング症候群の治療の概要overview of the treatment of cushings syndrome [show details]
…taken enough glucocorticoid for a long enough time to cause Cushing syndrome will have a period of hypothalamic-pituitary adrenal insufficiency when therapy is discontinued. Thus, gradual withdrawal is necessary …
5. 成人の肥満：疫学および危険因子obesity in adults etiology and risk factors [show details]
…as medications across a spectrum of diseases, can alter body weight and even lead to obesity Hypothalamic obesity is a rare syndrome in humans that can be regularly produced in animals by injury to the …

English Journal

Diagnosis and Management of Anabolic Androgenic Steroid Use.

, A A, B B, B B, .
The Journal of clinical endocrinology and metabolism. 2019 Jul;104(7)2490-2500.
The lifetime prevalence of anabolic androgenic steroid (AAS) use is estimated at 1% to 5% worldwide. AAS use occurs primarily male elite athletes and men who want a muscular appearance. The evidence for effective, safe management of AAS cessation and withdrawal is weak. Key studies were extracted fr
PMID 30753550

Multi-system reproductive metabolic disorder: significance for the pathogenesis and therapy of polycystic ovary syndrome (PCOS).

Li Y, Chen C, Ma Y, Xiao J, Luo G, Li Y, Wu D.
Life sciences. 2019 Jul;228()167-175.
Polycystic ovary syndrome (PCOS), a multisystem disease, is a major reason for female infertility around the world. It is no longer considered simply as a disease of ovary. Now researchers growing awareness of the multisystem features of this disease. PCOS has a higher relationship with metabolic di
PMID 31029778

Vasopressin regulates hypothalamic GnRH synthesis: Histomorphological evidence in hypothalamus and biological effects in GT1-7 cells.

Zhu Z, Zhao X, Huang F, Wang F, Wang W.
Life sciences. 2019 Jun;227()166-174.
To investigate the direct histomorphological clues and observe the biological effects of VP acting on gonadotropin-releasing hormone (GnRH) secretion. Immunofluorescence was conducted to investigate the expressions of GnRH and VP in experimental left varicocele (ELV) rats and ELV repair rats. The co
PMID 31026452

Japanese Journal

Pediatric Optic Pathway/Hypothalamic Glioma

AIHARA Yasuo,CHIBA Kentaro,EGUCHI Seiichiro,AMANO Kosaku,KAWAMATA Takakazu
Neurologia medico-chirurgica 58(1), 1-9, 2018
… Optic pathway/hypothalamic gliomas (OP/HGs) are rare astrocytic tumors that appear more commonly among young children and often are unresectable. … Initial manifestations are often visual disturbances, endocrinopathies and hypothalamic dysfunction such as the diencephalic syndrome, and sometimes hydrocephalus due to cerebrospinal fluid (CSF) outflow obstruction. …
NAID 130006309257

Atypical pituitary adenoma with MEN1 somatic mutation associated with abnormalities of DNA mismatch repair genes; MLH1 germline mutation and MSH6 somatic mutation

Uraki Shinsuke,Akamizu Takashi,Ariyasu Hiroyuki,Doi Asako,Furuta Hiroto,Nishi Masahiro,Sugano Kokichi,Inoshita Naoko,Nakao Naoyuki,Yamada Shozo
Endocrine Journal 64(9), 895-906, 2017
… Lynch syndrome is an autosomal, dominantly inherited syndrome caused by a defective mismatch repair (MMR) mechanism involved in the development of various tumors at an early age. … In this case study, we showed the occurrence of pituitary tumors associated with Lynch syndrome for the first time and performed genetic and immunohistochemical analysis to evaluate the genetic aberrations that might be related to the tumorigenesis and proliferation. …
NAID 130006107855