WordNet

abnormally low level of sodium in the blood; associated with dehydration

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1. 成人における低ナトリウム血症の治療の概要 overview of the treatment of hyponatremia in adults
2. 成人における低ナトリウム血症の原因 causes of hyponatremia in adults
3. 心不全患者における低ナトリウム血症 hyponatremia in patients with heart failure
4. 低ナトリウム血症の治療：抗利尿ホルモン不適合分泌（SIADH）症候群およびreset osmostat症候群 treatment of hyponatremia syndrome of inappropriate antidiuretic hormone secretion siadh and reset osmostat
5. 肝硬変患者における低ナトリウム血症 hyponatremia in patients with cirrhosis

English Journal

Therapeutic potential of vasopressin-receptor antagonists in heart failure.

Izumi Y, Miura K, Iwao H.Author information Department of Pharmacology, Osaka City University Medical School, Japan.AbstractArginine vasopressin (AVP) is a 9-amino acid peptide that is secreted from the posterior pituitary in response to high plasma osmolality and hypotension. AVP has important roles in circulatory and water homoeostasis, which are mediated by oxytocin receptors and by AVP receptor subtypes: V1a (mainly vascular), V1b (pituitary), and V2 (renal). Vaptans are orally and intravenously active nonpeptide vasopressin-receptor antagonists. Recently, subtype-selective nonpeptide vasopressin-receptor agonists have been developed. A selective V1a-receptor antagonist, relcovaptan, has shown initial positive results in the treatment of Raynaud's disease, dysmenorrhea, and tocolysis. A selective V1b-receptor antagonist, nelivaptan, has beneficial effects in the treatment of psychiatric disorders. Selective V2-receptor antagonists including mozavaptan, lixivaptan, satavaptan, and tolvaptan induce highly hypotonic diuresis without substantially affecting the excretion of electrolytes. A nonselective V1a/V2-receptor antagonist, conivaptan, is used in the treatment for euvolaemic or hypervolemic hyponatremia. Recent basic and clinical studies have shown that AVP-receptor antagonists, especially V2-receptor antagonists, may have therapeutic potential for heart failure. This review presents current information about AVP and its antagonists.
Journal of pharmacological sciences.J Pharmacol Sci.2014 Jan 18;124(1):1-6. Epub 2014 Jan 7.
Arginine vasopressin (AVP) is a 9-amino acid peptide that is secreted from the posterior pituitary in response to high plasma osmolality and hypotension. AVP has important roles in circulatory and water homoeostasis, which are mediated by oxytocin receptors and by AVP receptor subtypes: V1a (mainly
PMID 24401675

Generalized seizures as the first manifestation of multihormonal pituitary hormone deficiency causing normovolemic hyponatremia.

Wójcik M, Janus D, Herman-Sucharska I, Starzyk JB.Author information Department of Pediatric and Adolescent Endocrinology, Chair of Pediatrics, Polish-American Pediatric Institute, Jagiellonian University, Medical College, Cracow, Poland ; Department of Pediatric and Adolescent Endocrinology, Children's University Hospital in Cracow, Cracow, Poland.AbstractPatient: Female, 14 Final Diagnosis: Multiple pituitary hormone deficiency Symptoms: Hyponatremia Medication: - Clinical Procedure: Endovascular embolectomy Specialty: Endocrinology and Metabolic Objective: Patient complains/malpractice.
The American journal of case reports.Am J Case Rep.2013 Nov 26;14:507-10. doi: 10.12659/AJCR.889448.
Patient: Female, 14 Final Diagnosis: Multiple pituitary hormone deficiency Symptoms: Hyponatremia Medication: - Clinical Procedure: Endovascular embolectomy Specialty: Endocrinology and Metabolic Objective: Patient complains/malpractice.BACKGROUND: Hyponatremia is one of the most common electrolyte
PMID 24319529

Use of conivaptan for management of hyponatremia following surgery for Cushing's disease.

Breshears JD, Jiang B, Rowland NC, Kunwar S, Blevins LS.Author information California Center for Pituitary Disorders, Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA. Electronic address: breshearsj@neurosurg.ucsf.edu.AbstractBACKGROUND: Hyponatremia due to syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a common osmoregulatory complication following surgery for Cushing's disease. Conventional management includes water restriction and sodium repletion, however this regimen does not address the underlying pathophysiology of excessive vasopressin production. Vaptans are arginine vasopressin receptor antagonists shown to be effective in correcting water excess in other disease states of euvolemic and hypervolemic hyponatremia. The use of these agents has not been reported in Cushing's patients.
Clinical neurology and neurosurgery.Clin Neurol Neurosurg.2013 Nov;115(11):2358-61. doi: 10.1016/j.clineuro.2013.08.019. Epub 2013 Aug 27.
BACKGROUND: Hyponatremia due to syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a common osmoregulatory complication following surgery for Cushing's disease. Conventional management includes water restriction and sodium repletion, however this regimen does not address the underly
PMID 24041963