高血圧性腎硬化症
WordNet
- having abnormally high blood pressure
- a person who has abnormally high blood pressure
- kidney disease that is usually associated with hypertension; sclerosis of the renal arterioles reduces blood flow that can lead to kidney failure and heart failure (同)nephroangiosclerosis
PrepTutorEJDIC
- 高血圧の
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/14 12:54:31」(JST)
[Wiki en表示]
| Hypertensive nephropathy |
| Classification and external resources |
Micrograph showing renal arterial hyalinosis - pink ring right-of-centre. PAS stain. |
| ICD-10 |
I12 |
| ICD-9 |
403 |
Hypertensive nephropathy (or "hypertensive nephrosclerosis", or "Hypertensive renal disease") is a medical condition referring to damage to the kidney due to chronic high blood pressure.
It should be distinguished from "renovascular hypertension" (I15.0), which is a form of secondary hypertension.
In the kidneys, as a result of benign arterial hypertension, hyaline (pink, amorphous, homogeneous material) accumulates in the wall of small arteries and arterioles, producing the thickening of their walls and the narrowing of the lumina — hyaline arteriolosclerosis. Consequent ischemia will produce tubular atrophy, interstitial fibrosis, glomerular alterations (smaller glomeruli with different degrees of hyalinization - from mild to sclerosis of glomeruli) and periglomerular fibrosis. In advanced stages, renal failure will occur. Functional nephrons have dilated tubules, often with hyaline casts in the lumens. Additional complications often associated with hypertensive nephropathy include glomerular damage resulting in proteinuria and hematuria.
See also
External links
- Photo at Atlas of Pathology
- Tylicki L, Rutkowski B (2003). "[Hypertensive nephropathy: pathogenesis, diagnosis and treatment]" (in Polish). Pol. Merkur. Lekarski 14 (80): 168–73. PMID 12728683.
- Luft FC (October 2000). "Hypertensive nephrosclerosis-a cause of end-stage renal disease?". Nephrol Dial Transplant. 15 (10): 1515–7. doi:10.1093/ndt/15.10.1515. PMID 11007815. http://ndt.oxfordjournals.org/cgi/content/full/15/10/1515.
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Cardiovascular disease: vascular disease · Circulatory system pathology (I70–I99, 440–456)
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Arteries, arterioles
and capillaries |
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Inflammation
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Arteritis (Aortitis) · Buerger's disease
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Arterial occlusive disease/
peripheral vascular disease
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Arteriosclerosis
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Atherosclerosis (Foam cell, Fatty streak, Atheroma, Intermittent claudication) · Monckeberg's arteriosclerosis · Arteriolosclerosis (Hyaline, Hyperplastic, oxycholesterol, cholesterol, LDL, trans fat)
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Stenosis
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Renal artery stenosis · Carotid artery stenosis
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Other
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Fibromuscular dysplasia · Degos disease · Aortoiliac occlusive disease · Raynaud's phenomenon/Raynaud's disease · Erythromelalgia
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Aneurysm/dissection/
pseudoaneurysm
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torso: Aortic aneurysm (Thoracic aortic aneurysm, Abdominal aortic aneurysm) · Aortic dissection · Coronary artery aneurysm
head/neck: Cerebral aneurysm · Intracranial berry aneurysm · Carotid artery dissection · Vertebral artery dissection · Familial aortic dissection
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Vascular malformation
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Arteriovenous malformation · Arteriovenous fistula · Telangiectasia (Hereditary hemorrhagic telangiectasia)
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Vascular nevus
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Spider angioma · Halo nevus · Cherry hemangioma
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| Veins |
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Inflammation
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Phlebitis
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Venous thrombosis/
Thrombophlebitis
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primarily lower limb (Deep vein thrombosis)
abdomen (Hepatic veno-occlusive disease, Budd–Chiari syndrome, May-Thurner syndrome, Portal vein thrombosis, Renal vein thrombosis)
upper limb/torso (Paget-Schroetter disease, Mondor's disease)
head (Cerebral venous sinus thrombosis)
Post-thrombotic syndrome
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Varicose veins
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Varicocele · Gastric varices · Portacaval anastomosis (Hemorrhoid, Esophageal varices, Caput medusae)
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Other
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Superior vena cava syndrome · Inferior vena cava syndrome · Venous ulcer · Chronic venous insufficiency · Chronic cerebrospinal venous insufficiency
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| Arteries or veins |
Vasculitis · Thrombosis · Embolism (Pulmonary embolism, Cholesterol embolism, Paradoxical embolism) · Angiopathy (Macroangiopathy, Microangiopathy)
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| Blood pressure |
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Hypertension
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Hypertensive heart disease · Hypertensive nephropathy · Essential hypertension · Secondary hypertension (Renovascular hypertension) · Pulmonary hypertension · Malignant hypertension · Benign hypertension · Systolic hypertension · White coat hypertension
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Hypotension
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Orthostatic hypotension
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anat (a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot
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noco/syva/cong/lyvd/tumr, sysi/epon, injr
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proc, drug (C2s+n/3/4/5/7/8/9)
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Urinary system · Pathology · Urologic disease / Uropathy (N00–N39, 580–599)
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| Abdominal |
Nephropathy/
(nephritis+
nephrosis) |
Glomerulopathy/
glomerulitis/
(glomerulonephritis+
glomerulonephrosis) |
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Primarily
nephrotic
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Non-proliferative
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Minimal change · Focal segmental · Membranous
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Proliferative
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Mesangial proliferative · Endocapillary proliferative Membranoproliferative/mesangiocapillary
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By condition
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Diabetic · Amyloidosis
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Type I RPG/Type II hypersensitivity
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Goodpasture's syndrome
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Type II RPG/Type III hypersensitivity
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Post-streptococcal · Lupus (DPN) · IgA/Berger's
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Type III RPG/Pauci-immune
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Wegener's granulomatosis · Microscopic polyangiitis · Churg-Strauss Syndrome
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Tubulopathy/
tubulitis
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Proximal
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RTA (RTA 2) · Fanconi syndrome
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Thick ascending
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Bartter syndrome
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Distal convoluted
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Gitelman syndrome
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Collecting duct
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Liddle's syndrome · RTA (RTA 1) · Diabetes insipidus (Nephrogenic)
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Renal papilla
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Renal papillary necrosis
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Major calyx/pelvis
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Hydronephrosis · Pyonephrosis · Reflux nephropathy
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Any/all
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Acute tubular necrosis
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Interstitium
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Interstitial nephritis (Pyelonephritis, Danubian endemic familial nephropathy)
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Any/all
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General syndromes
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Renal failure (Acute renal failure, Chronic renal failure) · Uremic pericarditis · Uremia
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Vascular
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Renal artery stenosis · Renal Ischemia · Hypertensive nephropathy · Renovascular hypertension · Renal Cortical Necrosis
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Other
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Analgesic nephropathy · Renal osteodystrophy · Nephroptosis · Abderhalden-Kaufmann-Lignac syndrome
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Ureter
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Ureteritis · Ureterocele · Megaureter
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| Pelvic |
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Bladder
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Cystitis (Interstitial cystitis, Hunner's ulcer, Trigonitis, Hemorrhagic cystitis) · Neurogenic bladder · Bladder sphincter dyssynergia · Vesicointestinal fistula · Vesicoureteral reflux
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Urethra
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Urethritis (Non-gonococcal urethritis) · Urethral syndrome · Urethral stricture/Meatal stenosis · Urethral caruncle
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| Any/all |
Obstructive uropathy · Urinary tract infection · Retroperitoneal fibrosis · Urolithiasis (Bladder stone, Kidney stone, Renal colic) · Malacoplakia · Urinary incontinence (Stress, Urge, Overflow)
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noco/acba/cong/tumr, sysi/epon, urte
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proc/itvp, drug (G4B), blte, urte
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UpToDate Contents
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English Journal
- Hypertension-attributed nephropathy: what's in a name?
- Freedman BI1, Cohen AH2.
- Nature reviews. Nephrology.Nat Rev Nephrol.2015 Nov 10. doi: 10.1038/nrneph.2015.172. [Epub ahead of print]
- Unrelated disease processes commonly occur in non-diabetic individuals with mild-to-moderate hypertension and low level or absent proteinuria who present with chronic kidney disease: primary glomerulosclerosis in those with recent African ancestry, and arteriolar nephrosclerosis with resultant glome
- PMID 26553514
- Development of Potent and Selective Tissue Transglutaminase Inhibitors: Their Effect on TG2 Function and Application in Pathological Conditions.
- Badarau E1, Wang Z1, Rathbone DL1, Costanzi A1, Thibault T1, Murdoch CE2, El Alaoui S3, Bartkeviciute M2, Griffin M4.
- Chemistry & biology.Chem Biol.2015 Oct 22;22(10):1347-61. doi: 10.1016/j.chembiol.2015.08.013. Epub 2015 Oct 9.
- Potent-selective peptidomimetic inhibitors of tissue transglutaminase (TG2) were developed through a combination of protein-ligand docking and molecular dynamic techniques. Derivatives of these inhibitors were made with the aim of specific TG2 targeting to the intra- and extracellular space. A cell-
- PMID 26456735
- Urinary mRNA levels of ELR-negative CXC chemokine ligand and extracellular matrix in diabetic nephropathy.
- Wang G1, Lai FM1,2, Chow KM1, Kwan BC1, Pang WF1, Luk CC1, Leung CB1, Li PK1, Szeto CC1.
- Diabetes/metabolism research and reviews.Diabetes Metab Res Rev.2015 Oct;31(7):699-706. doi: 10.1002/dmrr.2654. Epub 2015 May 13.
- BACKGROUND: Inflammation and fibrosis play important roles in the progression of diabetic nephropathy. We determine the urinary mRNA levels of ELR-CXC chemokine ligand and extracellular matrix in diabetic nephropathy.METHODS: We studied 26 patients with biopsy-proven diabetic nephropathy, 15 with hy
- PMID 25865428
Japanese Journal
- 糖尿病性腎症と高血圧性腎硬化症の病理診断への手引き
- 佐藤 博,鈴木 芳樹,北村 博司 [他]
- The Japanese journal of nephrology = 日本腎臓学会誌 57(4), 649-725, 2015
- NAID 40020503067
- 高血圧性腎硬化症 (第5土曜特集 腎臓病のすべて) -- (腎臓病各論 : 診断とエビデンスに基づいた治療)
- レボフロキサシンによる腱障害を発症した透析患者の3例
- 岡 英明,宿理 朋哉,相原 成志 [他],原 雅俊,是澤 麻衣,上村 太朗,原田 篤実
- 日本透析医学会雑誌 47(11), 703-708, 2014
- 症例1は54歳, 女性. 慢性間質性腎炎で血液透析中であった. 膀胱炎でレボフロキサシン (LVFX) が開始され, 4日目より両側アキレス腱 (AT) および両拇指伸筋腱, 屈筋腱の疼痛が出現した. 服薬を中止するも改善せず, 薬剤性腱障害と診断した. 薬剤中止後2か月で両拇指痛は消失し, 4か月後に両AT痛も消失した. 症例2は79歳, 男性. 慢性糸球体腎炎で腹膜透析中であった. 好酸球性腹 …
- NAID 130004706588
Related Links
- nephrosclerosis [nef″ro-sklĕ-ro´sis] hardening of the kidney, usually associated with hypertension and disease of the renal arterioles. It is characterized as benign or malignant depending on the severity and rapidity of the hypertension ...
- Pathogenesis My conviction as to the reality of hypertensive nephrosclerosis as a cause of ESRD perhaps relates, in part, to my varied geographical clinical investigative experiences, initially in Scotland then in ...
★リンクテーブル★
[★]
- 英
- hypertensive nephrosclerosis
- 関
- 腎硬化症
[★]
- 関
- HBP、high blood pressure、HT、hypertension