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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/11/13 00:11:27」(JST)

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Hyperesthesia (or hyperaesthesia) is a condition that involves an abnormal increase in sensitivity to stimuli of the sense. "When a non-noxious stimulus causes the sensation of pain the area will be termed hyperaesthetic".^[1] Stimuli of the senses can include sound that one hears, foods that one tastes, textures that one feels, and so forth. Increased touch sensitivity is referred to as "tactile hyperesthesia", and increased sound sensitivity is called "auditory hyperesthesia". Tactile hyperesthesia may be a common symptom of many neurologic disorders such as herpes zoster, peripheral neuropathy and radiculopathies. In 1979, and then in 1994, Merskey, Bogduk, Noordenbos, Devor and others (a subcommittee of International Association for the Study of Pain) proposed, instead of hyperaestheia, the concept of allodynia, meaning "other pain", defined as a pain resulting from a stimulus that does not normally provoke pain.^[2]

In animals

Feline Hyperesthesia Syndrome is an uncommon but recognized condition in cats, particularly Siamese, Burmese, Himalayan, and Abyssinian cats. It can affect cats of all ages, though it is most prevalent in mature animals. The disease can be somewhat difficult to detect as it is characterized by brief bursts of abnormal behavior, lasting around a minute or two.^[3] It is also a symptom in dogs that have canine distemper disease (CD) caused by canine distemper virus (CDV).

References

^ Noordenbos, W. (1959). PAIN Problems pertaining to the transmission of nerve impulses which give rise to pain. Amsterdam : Elsevier
^ Merskey & Bogduk (Eds.) Classification of Chronic Pain. Seattle: IASP Task Force on Taxonomy, 1994
^ "Hyperesthesia Syndrome". Cornell Feline Health Center. Retrieved April 11, 2014.

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1. 貨幣状頭痛 nummular headache
2. 小児における耳痛の評価 evaluation of earache in children

English Journal

The utility of ionotropic glutamate receptor antagonists in the treatment of nociception induced by epidural glutamate infusion in rats.

Osgood DB, Harrington WF, Kenney EV, Harrington JF.Author information Department of Neurosurgical Research, Roger Williams Medical Center, Rhode Island, USA.AbstractBACKGROUND: The authors have previously demonstrated that human herniated disc material contains high concentrations of free glutamate. In an experimental model, elevated epidural glutamate concentrations in the lumbar spine can cause a focal hyperesthetic state.
Surgical neurology international.Surg Neurol Int.2013 Aug 21;4:106. doi: 10.4103/2152-7806.116791.
BACKGROUND: The authors have previously demonstrated that human herniated disc material contains high concentrations of free glutamate. In an experimental model, elevated epidural glutamate concentrations in the lumbar spine can cause a focal hyperesthetic state.METHODS: Rats underwent epidural glut
PMID 24032081

Angioleiomyoma of the knee: case series and an unusual cause of knee pain.

Jalgaonkar A, Dachepalli S, Farid M, Rao S.Author information Department of Trauma and Orthopaedics, South London Healthcare NHS Trust, Sidcup DA14 6LT, UK. azal4u@doctors.net.ukAbstractWe present a consecutive series of five patients with angioleiomyoma, a rare benign soft tissue tumor around the knee. Between 2005 and 2010, five patients with histopathologically confirmed diagnosis of angioleiomyoma of the knee underwent surgical excision. All five patients were Afro-caribbean in origin. The presenting feature was burning medial knee pain localized to a tender hyperesthetic swelling around the knee. The mean age of presentation was 45 years (range, 42 to 51 years), and the mean duration of symptom was 34 months (range, 12 to 96 months). Although magnetic resonance imaging (MRI) scans were helpful in locating and delineating the tumors, true diagnosis was established only by histopathology. All patients underwent surgical excision with complete resolution of symptoms. No recurrences were seen at an average follow-up of 16 months (range, 3 to 24 months). The treatment of these tumors, especially around the knee, is frequently delayed due to their late presentation and lack of awareness of this clinical condition. We recommend a high index of suspicion in patients, especially of Afro-caribbean origin, presenting with painful hyperesthetic subcutaneous swelling around the knee. Early investigation by MRI expedites the diagnosis, and surgical excision results in complete resolution of symptoms.
The journal of knee surgery.J Knee Surg.2011 Mar;24(1):33-7.
We present a consecutive series of five patients with angioleiomyoma, a rare benign soft tissue tumor around the knee. Between 2005 and 2010, five patients with histopathologically confirmed diagnosis of angioleiomyoma of the knee underwent surgical excision. All five patients were Afro-caribbean in
PMID 21618936

The role of adding hyaluronidase to fluoroscopically guided caudal steroid and hypertonic saline injection in patients with failed back surgery syndrome: a prospective, double-blinded, randomized study.

Yousef AA, EL-Deen AS, Al-Deeb AE.Author information Department of Anesthesia, Faculty of Medicine, Tanta University, Tanta, Egypt. ayman.yousef@rocketmail.comAbstractBACKGROUND: Failed back surgery syndrome (FBSS) has been reported to account for up to 40% of patients with chronic low back pain. Epidural fibrosis may be responsible for up to 30% of all cases of FBSS. Perineural fibrosis can interfere with cerebrospinal fluid-mediated nutrition, rendering the nerve root hyperesthetic and hypersensitive to compression. Traditionally, steroid injection has been used to treat low back pain and radiculopathy. The addition of hyaluronidase to the injectate has been reported to reduce the degree of fibrosis.
Pain practice : the official journal of World Institute of Pain.Pain Pract.2010 Nov-Dec;10(6):548-53. doi: 10.1111/j.1533-2500.2009.00357.x.
BACKGROUND: Failed back surgery syndrome (FBSS) has been reported to account for up to 40% of patients with chronic low back pain. Epidural fibrosis may be responsible for up to 30% of all cases of FBSS. Perineural fibrosis can interfere with cerebrospinal fluid-mediated nutrition, rendering the ner
PMID 20412501