English Journal

Parmar AS, Xu F, Pike DH, Belure SV, Hasan NF, Drzewiecki KE, Shreiber DI, Nanda V.
Biochemistry.Biochemistry.2015 Jul 30. [Epub ahead of print]
We explore the design of metal binding sites to modulate triple-helix stability of collagen and collagen-mimetic peptides. Globular proteins commonly utilize metals to connect tertiary structural elements that are well separated in sequence, constraining structure and enhancing stability. It is more
PMID 26225466

The prognostic value of plasma thrombospondin-1 concentrations after aneurysmal subarachnoid hemorrhage.

Shen YF1, Wang WH2, Yu WH3, Dong XQ4, Du Q3, Yang DB1, Wang H3, Jiang L3, Du YF3, Zhang ZY3, Zhu Q3, Che ZH3, Liu QJ1.
Clinica chimica acta; international journal of clinical chemistry.Clin Chim Acta.2015 Jul 8;448:155-160. doi: 10.1016/j.cca.2015.06.024. [Epub ahead of print]
BACKGROUND: Thrombospondin-1 is a homotrimeric glycoprotein with well known functions in hemostasis and angiogenesis. Its expression was increased after experimental intracerebral hemorrhage. We determined whether increased plasma thrombospondin-1 concentrations are predictive of clinical outcomes o
PMID 26162270

High-level expression, purification and characterization of carbazole dioxygenase, a three components dioxygenase, of Pseudomonas GBS.5.

Khan S1, Adhikari DK, Gupta S, Gupta N.
Biotechnology letters.Biotechnol Lett.2015 Jul 5. [Epub ahead of print]
OBJECTIVE: To investigate the conversion of carbazole into 2'-aminobiphenyl-2,3-diol using carbazole dioxygenase (CARDO) that is a multicomponent enzyme consisting of homotrimeric terminal oxygenases (CarAa), a ferredoxin (CarAc) and a ferredoxin reductase (CarAd) unit, encoded by the carAa, carAc a
PMID 26142698

Japanese Journal

Altered active site flexibility and a structural metal-binding site in eukaryotic dUTPase. Kinetic characterization, folding, and crystallographic studies of the homotrimeric Drosophila enzyme

SUBSTRATE-BINDING SPECIFICITY OF HSP47, A PROCOLLAGEN-SPECIFIC MOLECULAR CHAPERONE

Koide Takaki,Takahara Yoshifumi,Asada Shinichi,Nagata Kazuhiro
Connective tissue 34(1), 45, 2002-04-00
… Based on the data, we can now predict the possible binding sites for HSP47 in homotrimeric procollagen molecules. …
NAID 110004002454