関: homeo box、homeobox、homeobox gene

WordNet

one of various similar homeotic genes that are involved in bodily segmentation during embryonic development (同)homeobox_gene
(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
informal term for information; "give me the gen on your new line of computers"

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遺伝子

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/06/18 20:57:39」(JST)

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Homeotic genes cause the development of specific structures in plants and animals. They include many of the Hox and ParaHox genes which are important for segmentation,^[1] They also include the MADS-box-containing genes involved the ABC model of flower development.^[2] It is important to note that not all homeotic genes are Hox genes; the MADS- box genes are homeotic but not Hox genes. Equally not all hox genes are homeotic.

Homeotic genes are genes involved in developmental patterns and sequences. For example, homeotic genes are involved in determining where, when, and how body segments develop in flies. Alterations in these genes cause changes in patterns of body parts, sometimes causing dramatic effects such as legs growing in place of antennae or an extra set of wings or, in the case of plants, flowers with abnormal numbers of parts. An individual carrying an altered (mutant) version of a homeotic gene is known as a homeotic mutant.

Colinearity[edit]

Homeobox gene expression in Drosophila melanogaster

Rather surprisingly, it has been found that the sequence of homeotic genes in fruit flies, known as the Hox genes, are lined up in exactly the same order as the part of the fly they affect. That is to say, the first gene affects the mouth, the second the face, the third the top of the head and so on up until the eighth and final gene that affects the abdomen.^[3]

References[edit]

^ Young T, Rowland JE, van de Ven C, et al. (October 2009). "Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos". Dev. Cell 17 (4): 516–26. doi:10.1016/j.devcel.2009.08.010. PMID 19853565.
^ Theissen G (2001). "Development of floral organ identity: stories from the MADS house". Curr. Opin. Plant Biol. 4 (1): 75–85. doi:10.1016/S1369-5266(00)00139-4. PMID 11163172.
^ Nusslein-Volhard, C. and Wieschaus, E. (1980) Mutations affecting segment order and polarity in Drosophila, Nature 287: 795-801

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English Journal

Axis inhibition protein 2 polymorphisms may be a risk factor for families with isolated oligodontia.

Qin H1, Cai J2.
Molecular medicine reports.Mol Med Rep.2015 Mar;11(3):1899-904. doi: 10.3892/mmr.2014.2900. Epub 2014 Nov 7.
The objective of the present study was to search for Msh homeobox 1 (MSX1), paired box gene 9 (PAX9), ectodysplasin‑A (EDA) and axis inhibition protein 2 (AXIN2) variants in a family with isolated oligodontia and analyse the pathogenesis of mutations that result in oligodontia phenotypes. Member
PMID 25377791

Epigenetic modification of MiR-429 promotes liver tumour-initiating cell properties by targeting Rb binding protein 4.

Li L1, Tang J1, Zhang B2, Yang W1, LiuGao M1, Wang R3, Tan Y1, Fan J4, Chang Y3, Fu J1, Jiang F3, Chen C3, Yang Y1, Gu J5, Wu D5, Guo L1, Cao D1, Li H3, Cao G6, Wu M2, Zhang MQ5, Chen L1, Wang H7.
Gut.Gut.2015 Jan;64(1):156-67. doi: 10.1136/gutjnl-2013-305715. Epub 2014 Feb 26.
OBJECTIVE: Liver tumour-initiating cells (T-ICs) are critical for hepatocarcinogenesis. However, the underlying mechanism regulating the function of liver T-ICs remains unclear.METHODS: Tissue microarrays containing 242 hepatocellular carcinoma (HCC) samples were used for prognostic analysis. Magnet
PMID 24572141

Arabidopsis thaliana homeobox 12 (ATHB12), a homeodomain-leucine zipper protein, regulates leaf growth by promoting cell expansion and endoreduplication.

Hur YS1, Um JH, Kim S, Kim K, Park HJ, Lim JS, Kim WY, Jun SE, Yoon EK, Lim J, Ohme-Takagi M, Kim D, Park J, Kim GT, Cheon CI.
The New phytologist.New Phytol.2015 Jan;205(1):316-28. doi: 10.1111/nph.12998. Epub 2014 Sep 3.
Arabidopsis thaliana homeobox 12 (ATHB12), a homeodomain-leucine zipper class I (HD-Zip I) gene, is highly expressed in leaves and stems, and induced by abiotic stresses, but its role in development remains obscure. To understand its function during plant development, we studied the effects of loss
PMID 25187356

Japanese Journal

Ectopic expression of an AP3-like and a PI-like genes from 'Sekkoku' orchid (Dendrobium moniliforme) causes the homeotic conversion of sepals to petals in whorl 1 and the suppression of carpel development in whorl 4 in Arabidopsis flowers

SIRISAWAT Supatida,EZURA Hiroshi,FUKUDA Naoya,KOUNOSU Takahiro,HANDA Takashi
Plant biotechnology 27(2), 183-192, 2010-06-25
… Three class-B MADS-box genes, the paleotype AP3 genes DMAP3A and DMAP3B, and the PI-like gene DMPI, were isolated from a native orchid in Japan named ‘Sekkoku’ (Dendrobium moniliforme) and ectopically expressed in Arabidopsis. …
NAID 10026527239

The spatial expression patterns of DROOPING LEAF orthologs suggest a conserved function in grasses

ISHIKAWA Motokazu,OHMORI Yoshihiro,TANAKA Wakana,HIRABAYASHI Chizuru,MURAI Koji,OGIHARA Yasunari,YAMAGUCHI Takahiro,HIRANO Hiro-Yuki
Genes & genetic systems 84(2), 137-146, 2009-04-25
… The DROOPING LEAF (DL) gene regulates carpel specification in the flower and midrib formation in the leaf in Oryza sativa (rice). … Loss-of-function mutations in the dl locus cause homeotic transformation of carpels into stamens and lack of midrib, resulting in the drooping leaf phenotype. … DL is a member of the YABBY gene family and is closely related to the CRABS CLAW (CRC) gene in Arabidopsis thaliana. …
NAID 10024791705

「ホメオティック遺伝子」

　　[★]

英: homeotic gene
同: ホメオ遺伝子

ホメオティック変異を引き起こす遺伝子
発生段階において、ある体節に分布する細胞集団の運命を、将来的に特定の構造を形成しうる細胞へ分化するように方向付ける機能を持った調節遺伝子。ホメオドメインと呼ばれるDNA結合モチーフを持った核内タンパク質（転写因子として機能？）をコードしている。
哺乳類ではホメオティック遺伝子群を４つ持ち、HoxA, HoxB, HoxC, HoxDとよばれる。