ヒスチジンアンモニアリアーゼ
- 関
- histidase
WordNet
- a pungent gas compounded of nitrogen and hydrogen (NH3)
- an essential amino acid found in proteins that is important for the growth and repair of tissue
PrepTutorEJDIC
- アンモニア / アンモニア水(ammonia water)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/01/21 19:30:21」(JST)
[Wiki en表示]
| Histidine ammonia-lyase |
| Identifiers |
| Symbols |
HAL ; HIS; HSTD |
| External IDs |
OMIM: 609457 MGI: 96010 HomoloGene: 68229 ChEMBL: 4003 GeneCards: HAL Gene |
| EC number |
4.3.1.3 |
| Gene ontology |
| Molecular function |
• histidine ammonia-lyase activity
|
| Cellular component |
• cytosol
|
| Biological process |
• histidine catabolic process
• biosynthetic process
• histidine catabolic process to glutamate and formamide
• histidine catabolic process to glutamate and formate
• cellular nitrogen compound metabolic process
• small molecule metabolic process
|
| Sources: Amigo / QuickGO |
|
| Orthologs |
| Species |
Human |
Mouse |
|
| Entrez |
3034 |
15109 |
|
| Ensembl |
ENSG00000084110 |
ENSMUSG00000020017 |
|
| UniProt |
P42357 |
P35492 |
|
| RefSeq (mRNA) |
NM_001258333 |
NM_010401 |
|
| RefSeq (protein) |
NP_001245262 |
NP_034531 |
|
| Location (UCSC) |
Chr 12:
96.37 – 96.39 Mb |
Chr 10:
93.49 – 93.52 Mb |
|
| PubMed search |
[1] |
[2] |
|
|
|
| histidine ammonia-lyase |
| Identifiers |
| EC number |
4.3.1.3 |
| CAS number |
9013-75-6 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
Histidine ammonia-lyase (or histidase, or histidinase) is an enzyme that in humans is encoded by the HAL gene.[1][2] Histidase converts histidine into ammonia and urocanic acid.
Contents
- 1 Function
- 2 Pathology
- 3 Further reading
- 4 References
- 5 External links
Function
Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid.[1] The reaction is catalyzed by an electrophilic co-factor which is formed autocatalytically by cyclization of the protein backbone of the enzyme.[3]
Pathology
Mutations in the gene for histidase are associated with histidinemia and urocanic aciduria.
Further reading
- Suchi M, Harada N, Wada Y, Takagi Y (1993). "Molecular cloning of a cDNA encoding human histidase". Biochim. Biophys. Acta 1216 (2): 293–5. doi:10.1016/0167-4781(93)90157-9. PMID 7916645.
- Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Eckhart L, Schmidt M, Mildner M, et al. (2008). "Histidase expression in human epidermal keratinocytes: regulation by differentiation status and all-trans retinoic acid". J. Dermatol. Sci. 50 (3): 209–15. doi:10.1016/j.jdermsci.2007.12.009. PMID 18280705.
- Welsh MM, Karagas MR, Applebaum KM, et al. (2008). "A role for ultraviolet radiation immunosuppression in non-melanoma skin cancer as evidenced by gene-environment interactions". Carcinogenesis 29 (10): 1950–4. doi:10.1093/carcin/bgn160. PMC 2556967. PMID 18641401.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. JSTOR 3074035. PMC 139241. PMID 12477932.
- Kawai Y, Moriyama A, Asai K, et al. (2005). "Molecular characterization of histidinemia: identification of four missense mutations in the histidase gene". Hum. Genet. 116 (5): 340–6. doi:10.1007/s00439-004-1232-5. PMID 15806399.
- Taylor RG, García-Heras J, Sadler SJ, et al. (1991). "Localization of histidase to human chromosome region 12q22→q24.1 and mouse chromosome region 10C2→D1". Cytogenet. Cell Genet. 56 (3-4): 178–81. doi:10.1159/000133082. PMID 2055114.
- Alemán G, Ortíz V, Langley E, et al. (2005). "Regulation by glucagon of the rat histidase gene promoter in cultured rat hepatocytes and human hepatoblastoma cells". Am. J. Physiol. Endocrinol. Metab. 289 (1): E172–9. doi:10.1152/ajpendo.00584.2004. PMID 15741241.
References
- ^ a b "Entrez Gene: histidine ammonia-lyase".
- ^ Suchi M, Sano H, Mizuno H, Wada Y (September 1995). "Molecular cloning and structural characterization of the human histidase gene (HAL)". Genomics 29 (1): 98–104. doi:10.1006/geno.1995.1219. PMID 8530107.
- ^ Schwede, TF; Rétey, J; Schulz, GE (Apr 27, 1999). "Crystal structure of histidine ammonia-lyase revealing a novel polypeptide modification as the catalytic electrophile.". Biochemistry 38 (17): 5355–5361. doi:10.1021/bi982929q. PMID 10220322.
External links
- Histidine Ammonia-Lyase at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
|
Carbon-nitrogen lyases (EC 4.3)
|
|
| 4.3.1: ammonia-lyases |
- Histidine ammonia-lyase
- Formiminotransferase cyclodeaminase
- Serine dehydratase
|
|
| 4.3.2: amidine-lyases |
- Argininosuccinate lyase
- Adenylosuccinate lyase
|
|
- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
|
|
|
|
|
Metabolism: Protein metabolism, synthesis and catabolism enzymes (essential in CAPS)
|
|
| K→acetyl-CoA |
| LYSINE→ |
- Saccharopine dehydrogenase
- Glutaryl-CoA dehydrogenase
|
|
| LEUCINE→ |
- Branched chain aminotransferase
- Branched-chain alpha-keto acid dehydrogenase complex
- Isovaleryl coenzyme A dehydrogenase
- Methylcrotonyl-CoA carboxylase
- Methylglutaconyl-CoA hydratase
- 3-hydroxy-3-methylglutaryl-CoA lyase
|
|
| TRYPTOPHAN→ |
- Indoleamine 2,3-dioxygenase/Tryptophan 2,3-dioxygenase
- Arylformamidase
- Kynureninase
- 3-hydroxyanthranilate oxidase
- Aminocarboxymuconate-semialdehyde decarboxylase
- Aminomuconate-semialdehyde dehydrogenase
|
|
| PHENYLALANINE→tyrosine→ |
|
|
|
| G |
G→pyruvate
→citrate |
| glycine→serine→ |
- Serine hydroxymethyltransferase
- Serine dehydratase
- glycine→creatine: Guanidinoacetate N-methyltransferase
- Creatine kinase
|
|
| alanine→ |
|
|
| cysteine→ |
|
|
| threonine→ |
- L-threonine dehydrogenase
|
|
|
G→glutamate→
α-ketoglutarate |
| HISTIDINE→ |
- Histidine ammonia-lyase
- Urocanate hydratase
- Formiminotransferase cyclodeaminase
|
|
| proline→ |
- Proline oxidase
- Pyrroline-5-carboxylate reductase
- 1-Pyrroline-5-carboxylate dehydrogenase/ALDH4A1
- PYCR1
|
|
| arginine→ |
- Ornithine aminotransferase
- Ornithine decarboxylase
- Agmatinase
|
|
| →alpha-ketoglutarate→TCA |
|
|
| Other |
- cysteine+glutamate→glutathione: Gamma-glutamylcysteine synthetase
- Glutathione synthetase
- Gamma-glutamyl transpeptidase
- glutamate→glutamine: Glutamine synthetase
- Glutaminase
|
|
|
G→propionyl-CoA→
succinyl-CoA |
| VALINE→ |
- Branched chain aminotransferase
- Branched-chain alpha-keto acid dehydrogenase complex
- Enoyl-CoA hydratase
- 3-hydroxyisobutyryl-CoA hydrolase
- 3-hydroxyisobutyrate dehydrogenase
- Methylmalonate semialdehyde dehydrogenase
|
|
| ISOLEUCINE→ |
- Branched chain aminotransferase
- Branched-chain alpha-keto acid dehydrogenase complex
- 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
|
|
| METHIONINE→ |
- generation of homocysteine: Methionine adenosyltransferase
- Adenosylhomocysteinase
- regeneration of methionine: Methionine synthase/Homocysteine methyltransferase
- Betaine-homocysteine methyltransferase
- conversion to cysteine: Cystathionine beta synthase
- Cystathionine gamma-lyase
|
|
| THREONINE→ |
|
|
| →succinyl-CoA→TCA |
- Propionyl-CoA carboxylase
- Methylmalonyl CoA epimerase
- Methylmalonyl-CoA mutase
|
|
|
| G→fumarate |
| PHENYLALANINE→tyrosine→ |
- Phenylalanine hydroxylase
- Tyrosine aminotransferase
- 4-Hydroxyphenylpyruvate dioxygenase
- Homogentisate 1,2-dioxygenase
- Fumarylacetoacetate hydrolase
- tyrosine→melanin: Tyrosinase
|
|
|
| G→oxaloacetate |
| asparagine→aspartate→ |
- Asparaginase/Asparagine synthetase
- Aspartate transaminase
|
|
|
|
Index of inborn errors of metabolism
|
|
| Description |
- Metabolism
- Enzymes and pathways: citric acid cycle
- glycolysis
- glycogenesis and glycogenolysis
- fructose and galactose
- pentose phosphate
- glycoproteins
- glycosaminoglycans
- lipid
- phospholipid
- cholesterol and steroid
- lipoprotein
- sphingolipids
- eicosanoids
- amino acid
- urea cycle
- heme and porphyrin
- nucleotide
|
|
| Disorders |
- Citric acid cycle and electron transport chain
- Carbohydrate
- Glycoprotein
- Proteoglycan
- Fatty-acid
- Phospholipid
- Cholesterol and steroid
- Lipid
- Lipid storage
- Eicosanoid
- Amino acid
- Purine-pyrimidine
- Heme metabolism
- Symptoms and signs
|
|
| Treatment |
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- In vivo and in vitro characterization of TEV protease mutants.
- Wei L, Cai X, Qi Z, Rong L, Cheng B, Fan J.SourceKey Laboratory of Crop Biology of Anhui Province, Anhui Agricultural University, Hefei, China.
- Protein expression and purification.Protein Expr Purif.2012 Jun;83(2):157-63. Epub 2012 Mar 28.
- Tobacco etch virus protease (TEVp) is frequently applied in the cleavage of fusion protein. However, production of TEV protease in Escherichia coli is hampered by low yield and poor solubility, and auto-cleavage of wild type TEVp gives rise to the loss-of-function. Previously it was reported that TE
- PMID 22484199
- Neonatal blue light phototherapy and melanocytic nevi: a twin study.
- Csoma Z, Tóth-Molnár E, Balogh K, Polyánka H, Orvos H, Ocsai H, Kemény L, Széll M, Oláh J.SourceDepartment of Dermatology and Allergology, University of Szeged, Szeged, Hungary. csomazs@mail.derma.szote.u-szeged.hu
- Pediatrics.Pediatrics.2011 Oct;128(4):e856-64. Epub 2011 Sep 19.
- BACKGROUND: Neonatal blue light phototherapy (NBLP) has been widely and successfully used for the treatment of neonatal jaundice to reduce the plasma concentration of bilirubin and, hence, to prevent kernicterus. Only a few and controversial data are available in the literature as to how NBLP influe
- PMID 21930537
Japanese Journal
- 41.Imazamethabenz methyl処理が花器官形成に与える影響(口頭発表)
- 島田 淳巳
- 植物化学調節学会研究発表記録集 (43), 55, 2008-10-06
- … Since phenylalanine ammonia-lyase (PAL) was related to anthocyanin synthesis, PAL activity was measured in corolla tissue. … Proline, histidine and cysteine levels significantly increased, but glutamic acid, aspartic acid and methionine levels were reduced in the corollas. …
- NAID 110007468215
- 564 アンモニアリアーゼによる非天然型アミノ酸の合成(酵素・酵素工学・タンパク質工学,一般講演)
Related Links
- Histidine ammonia-lyase (or histidase, or histidinase) is an enzyme that in humans is encoded by the HAL gene. Histidase ... Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative ...
- 17 Sep 2012 ... This family includes phenylalanine ammonia-lyase, (PAL; EC:4.3.1.24), histidine ammonia-lyase, (HAL; EC:4.3.1.3), and tyrosine aminomutase, (EC:5.4.3.6) [ PubMed: 7925471, PubMed: 10220322, PubMed: 16793524].
★リンクテーブル★
[★]
- 英
- histidase
- 関
- ヒスチジンアンモニアリアーゼ histidine ammonia-lyase、ヒスチジン
臨床関連
[★]
- 英
- [[]]
- 同
- histidine ammonia-lyase
- 関
- [[]]
- 同
- histidine ammonia-lyase
[★]
- 英
- histidine ammonia-lyase
- 関
- ヒスチダーゼ
[★]
アンモニア NH3