WordNet

a harmful or corrupting agency; "bigotry is a virus that must not be allowed to spread"; "the virus of jealousy is latent in everyone"
(virology) ultramicroscopic infectious agent that replicates itself only within cells of living hosts; many are pathogenic; a piece of nucleic acid (DNA or RNA) wrapped in a thin coat of protein
a software program capable of reproducing itself and usually capable of causing great harm to files or other programs on the same computer; "a true virus cannot spread to another computer without human assistance" (同)computer virus
inflammation of the liver caused by a virus or a toxin
the 5th letter of the Roman alphabet (同)e
the base of the natural system of logarithms; approximately equal to 2.718282...

PrepTutorEJDIC

ビールス,ろ過性病原体
肝[臓]炎
einsteiniumの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/12/25 01:37:07」(JST)

wiki en

[Wiki en表示]

The Hepatitis E virus, or HEV, is the causative agent of Hepatitis E. Its taxonomic name is Orthohepevirus A.

The global burden of infections from the two major genotypes (1 and 2) is estimated at 20 million per year, leading to 70,000 deaths and 3,000 stillbirths.^[1]

The virus particle was first visualised in 1983^[2] but was only molecularly cloned in 1990.^[3]

Genome and proteome

HEV can be classified into four different genotypes from different geographical regions: genotype 1 (Asia), genotype 2 (Africa and Mexico), genotype 3 (Europe and North America) and genotype 4 (Asia).^[4]

The viral genome a single-strand of positive-sense RNA that is approximately 7200 bases in length. It encodes 3 proteins (O1, O2, O3), two of which are polyproteins, that is, they are cleaved into fragments which carry out the actual functions of the virus (see figure). The O1 protein consists of 7 such fragments, namely Met (Methyltransferase), Y (Y-domain), Plp (Papain like protease), V (proline-rich variable region), X (X-domain, macro-domain), Hel (Helicase), and Rdrp (RNA dependent RNA polymerase). The Pvx domain is a fusion protein consisting of the Plp, V and X domains. The O3 protein is encoded by a single open reading frame (ORF3). The O2 protein encodes the capsid, which is composed of 3 domains, namely the shell domain (S) and two protruding domains (P1, P2).^[5] Numbers in the figure indicate positions in the RNA sequence.

Interactome

The protein-protein Interactome among HEV proteins has been mapped by Osterman et al. (2015) who found 25 interactions among the 10 proteins studied. 24 of these interactions were considered as of "high quality".^[6]

Structure

The viral particles are 27 to 34 nanometers in diameter and are non-enveloped.^[2]

Taxonomy

It was previously classified in the Caliciviridae family. However, its genome more closely resembles the rubella virus. It is now classified as a member of the genus Orthohepevirus in the Hepeviridae family.^[7]

References

^ Rein, D. B., Stevens, G. A., Theaker, J., Wittenborn, J. S. & Wiersma, S. T. (2012) The global burden of hepatitis E virus genotypes 1 and 2 in 2005. Hepatology 55, 988–97
^ ^a ^b Balayan MS, Andjaparidze AG, Savinskaya SS, et al. (1983). "Evidence for a virus in non-A, non-B hepatitis transmitted via the fecal-oral route". Intervirology. 20 (1): 23–31. doi:10.1159/000149370. PMID 6409836.
^ Reyes GR, Purdy MA, Kim JP, et al. (1990). "Isolation of a cDNA from the virus responsible for enterically transmitted non-A, non-B hepatitis". Science. 247 (4948): 1335–9. doi:10.1126/science.2107574. PMID 2107574.
^ Schlauder, G. G. & Mushahwar, I. K. (2001) Genetic heterogeneity of hepatitis E virus. J Med Virol 65, 282–92
^ Ahmad I, Holla RP, Jameel S (2011). "Molecular virology of hepatitis E virus". Virus Res. 161 (1): 47–58. doi:10.1016/j.virusres.2011.02.011. PMC 3130092. PMID 21345356.
^ Osterman A, Stellberger T, Gebhardt A, Kurz M, Friedel CC, Uetz P, Nitschko H, Baiker A, Vizoso-Pinto MG (2015). "The Hepatitis E virus intraviral interactome". Sci Rep. 5: 13872. doi:10.1038/srep13872. PMC 4604457. PMID 26463011.
^ "ICTV Virus Taxonomy: 2009 release". Retrieved 2011-12-02.

External links

Hepatitis E virus at the US National Library of Medicine Medical Subject Headings (MeSH)
Virus Pathogen Database and Analysis Resource (ViPR): Hepeviridae
"Hepatitis E virus". NCBI Taxonomy Browser. 12461.
"Orthohepevirus", Catalan Wikipedia (written by Veterinarian Students of the University Autonomy of Barcelona, Spain).

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. E型肝炎ウイルス感染 hepatitis e virus infection
2. 中央アフリカへの旅行によって感染する可能性のある疾患 diseases potentially acquired by travel to central africa
3. 南アジアへの旅行によって感染する可能性のある疾患 diseases potentially acquired by travel to south asia
4. 肝炎ウイルスと新生児：臨床症状および治療 hepatitis viruses and the newborn clinical manifestations and treatment
5. 妊娠時の肝胆道系疾患併発 intercurrent hepatobiliary disease during pregnancy

English Journal

Detection of hepatitis E virus RNA in raw sausages and liver sausages from retail in Germany using an optimized method.

Szabo K1, Trojnar E2, Anheyer-Behmenburg H3, Binder A4, Schotte U4, Ellerbroek L5, Klein G6, Johne R5.
International journal of food microbiology.Int J Food Microbiol.2015 Dec 23;215:149-56. doi: 10.1016/j.ijfoodmicro.2015.09.013. Epub 2015 Sep 21.
PMID 26433460

Removal of Rotavirus and Bacteriophages by Membrane Bioreactor Technology from Sewage.

Hmaied F1, Keskes S2, Jebri S3, Amri I3, Yahya M3, Loisy-Hamon F4, Lebeau B4, Hamdi M2.
Current microbiology.Curr Microbiol.2015 Nov;71(5):540-5. doi: 10.1007/s00284-015-0882-y. Epub 2015 Jul 26.
Human enteric viruses constitute a public health concern due to their low infectious dose and their resistance to environmental factors and to inactivation processes. We aimed at assessing the performance of a laboratory scale Submerged membrane bioreactor (SMBR) treating abattoir wastewaters for Ro
PMID 26210901

Neurologic Disorders in Immunocompetent Patients with Autochthonous Acute Hepatitis E.

Perrin HB, Cintas P, Abravanel F, Gérolami R, d'Alteroche L, Raynal JN, Alric L, Dupuis E, Prudhomme L, Vaucher E, Couzigou P, Liversain JM, Bureau C, Vinel JP, Kamar N, Izopet J, Peron JM.
Emerging infectious diseases.Emerg Infect Dis.2015 Nov;21(11). doi: 10.3201/eid2111.141789.
PMID 26490255

Japanese Journal

Detection of antibodies against hepatitis B virus surface antigen and hepatitis C virus core antigen in plasma with a waveguide-mode sensor

Journal of bioscience and bioengineering 123(6), 760-764, 2017-06
NAID 40021226022

当院の血液透析患者HCV感染者の治療と今後の展望

日本透析医学会雑誌 50(5), 281-287, 2017-05
NAID 40021227726

C型慢性肝炎患者のテラプレビルを含む3剤併用療法における栄養サポートの役割

日本静脈経腸栄養学会雑誌 = The journal of Japanese Society for Parenteral and Enteral Nutrition 32(1), 858-864, 2017-03
NAID 40021155083

Related Pictures

★リンクテーブル★

リンク元	「E型肝炎ウイルス」「HEV」
関連記事	「Es」「E」「virus」

「E型肝炎ウイルス」

Hepatitis E virus
	TEM micrograph of hepatitis E virions.
Virus classification
Group:	Group IV ((+)ssRNA)
Order:	Unassigned
Family:	Hepeviridae
Genus:	Orthohepevirus
Species:	Orthohepevirus A
Synonyms
	Hepatitis E virus;