同: HBIG

WordNet

the 2nd letter of the Roman alphabet (同)b
the blood group whose red cells carry the B antigen (同)type_B, group B
a class of proteins produced in lymph tissue in vertebrates and that function as antibodies in the immune response (同)Ig, immune serum globulin, immune gamma globulin, immune_globulin
inflammation of the liver caused by a virus or a toxin

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肝[臓]炎

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/04/29 19:49:16」(JST)

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Hepatitis B immune globulin (HBIG) is a human immune globulin that is used to prevent the development of hepatitis B.

Preparation

HBIG is prepared from the plasma of donors who have high antibody levels of the hepatitis B surface antigen. It is extracted from the Cohn fraction II. During the process, viruses are deactivated, and in the final steps, solvents used in the preparation are removed. The preparation is tested for absence of HIV, HCV, herpes virus, and reovirus.^[1]

Indications

HBIG is indicated as a postexposure prophylaxis for people at risk to develop hepatitis B because they have been recently exposed to body fluids of individuals who have hepatitis B. This includes babies of mothers with hepatitis B, sexual partners, healthcare workers, police and fire workers, and morticians.^[2] It provides a temporarily induced immunity by the transfer of immunoglobulins.

HBIG is given by either intramuscular (IM) or intravenous (IV) route, depending on the preparation. Side effects include allergic reactions, back pain, general feeling of discomfort, headaches, muscle pain, nausea, and pain or bleeding at the injection site. Allergy to human immune globulin is a contraindication. HIV has never been transmitted by HBIG.^[3] As with all blood-derived products, the transmission of prions is possible as a residual risk.

Concomitant vaccination

HBIG should be given within 14 days of exposure to the hepatitis B virus.^[3] The half-life of HBIG is about 3 weeks. In lieu of a booster administration of HBIG, a hepatitis B vaccination is initiated at the time of the initial HBIG administration, thus providing long term protection.^[4]

HBIG is classified as pregnancy category C substance by the U.S. Food and Drug Administration.

Brand names

Bayhep B
HepaGam B (US market; intravenous preparation)
HyperHEP B (US market; intramuscular preparation)
Nabi-HB
Nabi-HB NovaPlus

References

^ Product description with dose schedule Retrieved 2009-06-03
^ Mayo Clinic Retrieved 2009-06-03
^ ^a ^b BlueShield information Retrieved 2009-06-03
^ CDC recommendation for postexposure prophylaxis of hepatitis B Retrieved 2009-06-03

UpToDate Contents

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1. 慢性B型肝炎ウイルス感染に対する肝移植 liver transplantation for chronic hepatitis b virus infection
2. 医療従事者におけるB型肝炎ウイルスおよびC型肝炎ウイルス感染の予防 prevention of hepatitis b virus and hepatitis c virus infection among healthcare providers
3. 幼児、小児および思春期におけるB型肝炎ウイルス予防接種 hepatitis b virus immunization in infants children and adolescents
4. 肝炎ウイルスと新生児：臨床症状および治療 hepatitis viruses and the newborn clinical manifestations and treatment
5. B型肝炎と妊娠 hepatitis b and pregnancy

English Journal

A fast and simple label-free immunoassay based on a smartphone.

Giavazzi F1, Salina M1, Ceccarello E1, Ilacqua A2, Damin F3, Sola L3, Chiari M3, Chini B4, Cerbino R2, Bellini T5, Buscaglia M6.
Biosensors & bioelectronics.Biosens Bioelectron.2014 Aug 15;58:395-402. doi: 10.1016/j.bios.2014.02.077. Epub 2014 Mar 12.
Despite the continuous advancements in bio-molecular detection and fluidic systems integration, the realization of portable and high performance devices for diagnostic applications still presents major difficulties, mostly because of the need to combine adequate sensitivity with low cost of producti
PMID 24721381

Prevention of mother-to-child transmission of hepatitis B virus and hepatitis C virus.

Gentile I1, Zappulo E, Buonomo AR, Borgia G.
Expert review of anti-infective therapy.Expert Rev Anti Infect Ther.2014 Jul;12(7):775-82. doi: 10.1586/14787210.2014.920254. Epub 2014 May 20.
About 240 million people worldwide are chronically infected with hepatitis B virus (HBV). Vertical transmission is the most important mechanism of infection persistence in endemic areas. About 150 million people worldwide are chronically infected with hepatitis C virus (HCV). Mother-to-child transmi
PMID 24840817

Incomplete hepatitis B immunization, maternal carrier status, and increased risk of liver diseases: A 20-year cohort study of 3.8 million vaccinees.

Chien YC1, Jan CF, Chiang CJ, Kuo HS, You SL, Chen CJ.
Hepatology (Baltimore, Md.).Hepatology.2014 Jul;60(1):125-32. doi: 10.1002/hep.27048. Epub 2014 Jun 2.
Hepatitis B immunization has been documented to prevent fulminant hepatic failure (FHF) and hepatocellular carcinoma (HCC) by historical comparison studies in Taiwan. This study aimed to assess long-term risks and predictors of various liver diseases associated with incomplete immunization in 3.8 mi
PMID 24497203

Japanese Journal

Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation.

Chiba Tsutomu,Marusawa Hiroyuki,Ushijima Toshikazu
Gastroenterology 143(3), 550-563, 2012-09-00
… Chronic inflammation, regardless of infectious agents, plays important roles in the development of various cancers, particularly in digestive organs, including Helicobacter pylori-associated gastric cancer, hepatitis C virus-positive hepatocellular carcinoma, and colitis-associated colon cancers. …
NAID 120004873775

A case of monoclonal immunoglobulin G1-lambda deposition associated with membranous feature in a patient with hepatitis C viral infection

YAMADA Takehisa,ARAKAWA Yusuke,MII Akiko,KASHIWAGI Tetsuya,KANEKO Tomohiro,UTSUMI Koichi,MASUDA Yukinari,SHIMIZU Akira,IINO Yasuhiko,KATAYAMA Yasuo
Clinical and experimental nephrology 16(3), 468-472, 2012-06-01
NAID 10030808703

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★リンクテーブル★

リンク元	「HBIG」「B型肝炎免疫グロブリン」
関連記事	「B」

「HBIG」

Hepatitis B immune globulin
Clinical data
Trade names	HepaGam B
AHFS/Drugs.com	monograph
Pregnancy; category	US: C (Risk not ruled out);
Routes of; administration	intramuscular injection
Identifiers
CAS Registry Number
ATC code	J06BB04
Chemical data
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