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Optimization and validation of liquid chromatography and headspace-gas chromatography based methods for the quantitative determination of capsaicinoids, salicylic acid, glycol monosalicylate, methyl salicylate, ethyl salicylate, camphor and l-menthol in a topical formulation.

Pauwels J1, D'Autry W, Van den Bossche L, Dewever C, Forier M, Vandenwaeyenberg S, Wolfs K, Hoogmartens J, Van Schepdael A, Adams E.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2012 Feb 23;60:51-8. doi: 10.1016/j.jpba.2011.10.024. Epub 2011 Oct 25.
Capsaicinoids, salicylic acid, methyl and ethyl salicylate, glycol monosalicylate, camphor and l-menthol are widely used in topical formulations to relieve local pain. For each separate compound or simple mixtures, quantitative analysis methods are reported. However, for a mixture containing all abo
PMID 22094014

Allergic contact dermatitis from a veterinary antiinflammatory gel containing 2-hydroxyethyl salicylate.

Córdoba S, García-Donoso C, Villanueva CA, Borbujo J.
Dermatitis : contact, atopic, occupational, drug.Dermatitis.2011 May;22(3):171-2.
PMID 21569750

Barbaud A1.
Giornale italiano di dermatologia e venereologia : organo ufficiale, Società italiana di dermatologia e sifilografia.G Ital Dermatol Venereol.2009 Oct;144(5):527-36.
The management of patients who have developed a contact dermatitis due to topical drugs requires to stop the suspected drug application, to treat the patient with corticosteroid ointments, to perform dermatoallergological investigations e.g. drug patch tests in case of contact eczema and diluted pri
PMID 19834431