出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/09 18:50:40」(JST)
| glycine hydroxymethyltransferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.1.2.1 | ||||||||
| CAS number | 9029-83-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, a glycine hydroxymethyltransferase (EC 2.1.2.1) is an enzyme that catalyzes the chemical reaction
The 3 substrates of this enzyme are 5,10-methylenetetrahydrofolate, glycine, and H2O, whereas its two products are tetrahydrofolate and L-serine.
This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase. Other names in common use include serine aldolase, threonine aldolase, serine hydroxymethylase, serine hydroxymethyltransferase, allothreonine aldolase, L-serine hydroxymethyltransferase, L-threonine aldolase, serine hydroxymethyltransferase, and serine transhydroxymethylase. This enzyme participates in 5 metabolic pathways: glycine, serine and threonine metabolism, lysine degradation, cyanoamino acid metabolism, one carbon pool by folate, and methane metabolism. It employs one cofactor, pyridoxal phosphate.
As of late 2007, 18 structures have been solved for this class of enzymes, with PDB accession codes 1BJ4, 1DFO, 1EJI, 1EQB, 1KKJ, 1KKP, 1KL1, 1KL2, 1LS3, 1RV3, 1RV4, 1RVU, 1RVY, 1YJS, 1YJY, 1YJZ, 2A7V, and 2DKJ.
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| リンク元 | 「グリシンヒドロキシメチルトランスフェラーゼ」 |
| 関連記事 | 「hydroxymethyltransferase」 |