glutamate-5-semialdehyde dehydrogenase

グルタミン酸-5-セミアルデヒド脱水素酵素、グルタミン酸-5-セミアルデヒドデヒドロゲナーゼ

WordNet

1. a salt or ester of glutamic acid

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/09/13 04:35:18」(JST)

wiki en

[Wiki en表示]

glutamate-5-semialdehyde dehydrogenase
Identifiers
EC number	1.2.1.41
CAS number	54596-29-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) is an enzyme that catalyzes the chemical reaction

L-glutamate 5-semialdehyde + phosphate + NADP⁺ L-glutamyl 5-phosphate + NADPH + H⁺

The 3 substrates of this enzyme are L-glutamate 5-semialdehyde, phosphate, and NADP⁺, whereas its 3 products are L-glutamyl 5-phosphate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating). Other names in common use include beta-glutamylphosphate reductase, gamma-glutamyl phosphate reductase, beta-glutamylphosphate reductase, glutamate semialdehyde dehydrogenase, and glutamate-gamma-semialdehyde dehydrogenase. This enzyme participates in urea cycle and metabolism of amino groups.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1O20, 1VLU, and 2H5G.

References

• Baich A (1971). "The biosynthesis of proline in Escherichia coli: phosphate-dependent glutamate -semialdehyde dehydrogenase (NADP), the second enzyme in the pathway". Biochim. Biophys. Acta. 244 (1): 129–34. PMID 4399189. 

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 肝細胞障害を検出するための肝臓生化学検査 liver biochemical tests that detect injury to hepatocytes
• 2. 幼児の持続性高インスリン血症性低血糖症の病因、臨床的特徴、および診断 pathogenesis clinical features and diagnosis of persistent hyperinsulinemic hypoglycemia of infancy
• 3. 小児におけるクロストリジウムディフィシル感染：診断へのアプローチ clostridium difficile infection in children approach to diagnosis
• 4. 筋萎縮性側索硬化症の疫学および病因 epidemiology and pathogenesis of amyotrophic lateral sclerosis
• 5. 成人におけるクロストリジウム・ディフィシル：臨床症状および診断 clostridium difficile in adults clinical manifestations and diagnosis

English Journal

• [Evaluation of Salt Tolerance of Transgenic Tobacco Plants Bearing with P5CS1 Gene of Arabidopsis thaliana].

• Ibragimova SM, Trifonova EA, Filipenko EA, Shymny VK.
• Genetika.Genetika.2015 Dec;51(12):1368-75.
• Arabidopsis thaliana delta1-pyrroline-5-carhoxylate synthase 1 gene (P5CS1) cDNA was cloned under the control of the potent constitutive 35S RNA promoter of the cauliflower mosaic virus and transferred into genome of tobacco cv. Petit Havana SR-1 (Nicotiana tabacum L.) plants. It is shown that the c
• PMID 27055296

• Stress physiology functions of the Arabidopsis histidine kinase cytokinin receptors.

• Kumar MN1, Verslues PE1.
• Physiologia plantarum.Physiol Plant.2015 Jul;154(3):369-80. doi: 10.1111/ppl.12290. Epub 2014 Nov 3.
• Cytokinin signaling has complex effects on abiotic stress responses that remain to be fully elucidated. The Arabidopsis histidine kinases (AHKs), AHK2, AHK3 and CRE1 (cytokinin response1/AHK4) are the principle cytokinin receptors of Arabidopsis. Using a set of ahk mutants, we found dramatic differe
• PMID 25263537

• Isolation of the P5CS gene from reed canary grass and its expression under salt stress.

• Cong LL1, Zhang XQ2, Yang FY1, Liu SJ1, Zhang YW3.
• Genetics and molecular research : GMR.Genet Mol Res.2014 Oct 31;13(4):9122-33. doi: 10.4238/2014.October.31.28.
• Reed canary grass (RCG) is a perennial grass traditionally cultivated for forage. It is also used as fuel to produce energy in Finland and Sweden, and other countries have expressed interest in the cultivation of RCG. In China, arable land is limited. Salinity is considered to be a major factor limi
• PMID 25366804

---

★リンクテーブル★

リンク元	「グルタミン酸-5-セミアルデヒド脱水素酵素」
関連記事	「glutamate」「dehydrogenase」「dehydrogenases」

「グルタミン酸-5-セミアルデヒド脱水素酵素」

　　[★]

英

glutamate-5-semialdehyde dehydrogenase

関

グルタミン酸-5-セミアルデヒドデヒドロゲナーゼ

「glutamate」

　　[★]

グルタミン酸、グルタメート、グルタメイト、(化合物)グルタミン酸塩

　

「dehydrogenase」

　　[★] 脱水素酵素 デヒドロゲナーゼ

「dehydrogenases」

　　[★] 脱水素酵素 デヒドロゲナーゼ