WordNet

any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions

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The glycolytic enzyme aldolase C is up-regulated in rat forebrain microsomes and in the cerebrospinal fluid after repetitive fluoxetine treatment.

Sandoval M, Luarte A, Herrera-Molina R, Varas-Godoy M, Santibáñez M, Rubio FJ, Smit AB, Gundelfinger ED, Li KW, Smalla KH, Wyneken U.SourceLaboratorio de Neurociencias, Universidad de Los Andes, Santiago, Chile.
Brain research.Brain Res.2013 Jul 3;1520:1-14. doi: 10.1016/j.brainres.2013.04.049. Epub 2013 May 18.
The antidepressant drug fluoxetine is widely used for the treatment of a broad range of psychiatric disorders. Its mechanism of action is thought to involve cellular adaptations that are induced with a slow time course after initiation of treatment. To gain insight into the signaling pathways underl
PMID 23688545

Histidine augments the suppression of hepatic glucose production by central insulin action.

Kimura K, Nakamura Y, Inaba Y, Matsumoto M, Kido Y, Asahara S, Matsuda T, Watanabe H, Maeda A, Inagaki F, Mukai C, Takeda K, Akira S, Ota T, Nakabayashi H, Kaneko S, Kasuga M, Inoue H.SourceDepartment of Physiology and Metabolism, Brain/Liver Interface Medicine Research Center, Kanazawa University, Kanazawa, Japan.
Diabetes.Diabetes.2013 Jul;62(7):2266-77. doi: 10.2337/db12-1701. Epub 2013 Mar 8.
Glucose intolerance in type 2 diabetes is related to enhanced hepatic glucose production (HGP) due to the increased expression of hepatic gluconeogenic enzymes. Previously, we revealed that hepatic STAT3 decreases the expression of hepatic gluconeogenic enzymes and suppresses HGP. Here, we show that
PMID 23474485

Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance.

Kumashiro N, Beddow SA, Vatner DF, Majumdar SK, Cantley JL, Guebre-Egziabher F, Fat I, Guigni B, Jurczak MJ, Birkenfeld AL, Kahn M, Perler BK, Puchowicz MA, Manchem VP, Bhanot S, Still CD, Gerhard GS, Petersen KF, Cline GW, Shulman GI, Samuel VT.SourceHoward Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut.
Diabetes.Diabetes.2013 Jul;62(7):2183-94. doi: 10.2337/db12-1311. Epub 2013 Feb 19.
We measured the mRNA and protein expression of the key gluconeogenic enzymes in human liver biopsy specimens and found that only hepatic pyruvate carboxylase protein levels related strongly with glycemia. We assessed the role of pyruvate carboxylase in regulating glucose and lipid metabolism in rats
PMID 23423574