関: mesangial、mesangium

WordNet

of or relating to glomeruli

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/03/13 16:37:03」(JST)

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Renal corpuscle. The entire structure is the renal corpuscle. The blue structure (A) is the Bowman's capsule (2 and 3). The pink structure is the glomerulus with its capillaries. At the left, blood flows from the afferent areteriole (9), through the capillaries (10), and out the efferent arteriole (11). The mesangium is the pink structure inside the glomerulus between the capillaries (5a) and extending outside the glomerulus (5b).

In the glomerulus of the kidney, the mesangium is a structure associated with the capillaries. It is continuous with the smooth muscles of the arterioles. It is outside the capillary lumen, but surrounded by capillaries. It is in the middle (meso) between the capillaries (angis). It is contained by the basement membrane, which surrounds both the capillaries and the mesangium.

This term is often used interchangeably with mesangial cell, but in this context refers specifically to the intraglomerular mesangial cells. These cells are phagocytic and secrete the amorphous basement membrane-like material known as the mesangial matrix. They are typically separated from the lumen of the capillaries by endothelial cells.

External links

Mesangium at eMedicine Dictionary
Physiology at MCG 7/7ch03/7ch03p12
"Mesangium" at Dorland's Medical Dictionary

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UpToDate Contents

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1. 糸球体の免疫障害の機序 mechanisms of immune injury of the glomerulus
2. Chapter 2A：糸球体の解剖学的構造および機能 chapter 2a glomerular anatomy and function
3. 糸球体足細胞のバイオロジー biology of glomerular podocytes
4. 糸球体腎炎における組織損傷の病因 pathogenesis of tissue injury in glomerulonephritis
5. C型肝炎ウイルス感染関連腎疾患 renal disease associated with hepatitis c virus infection

English Journal

Therapeutic targeting of aldosterone: a novel approach to the treatment of glomerular disease.

Brem AS1, Gong R1.
Clinical science (London, England : 1979).Clin Sci (Lond).2015 May;128(9):527-35. doi: 10.1042/CS20140432.
Numerous studies have established a role for mineralocorticoids in the development of renal fibrosis. Originally, the research focus for mineralocorticoid-induced fibrosis was on the collecting duct, where 'classical' mineralocorticoid receptors (MRs) involved with electrolyte transport are present.
PMID 25671776

siRNA Delivery to the Glomerular Mesangium Using Polycationic Cyclodextrin Nanoparticles Containing siRNA.

Zuckerman JE1, Gale A, Wu P, Ma R, Davis ME.
Nucleic acid therapeutics.Nucleic Acid Ther.2015 Apr;25(2):53-64. doi: 10.1089/nat.2014.0505. Epub 2015 Mar 3.
There is an urgent need for new therapies that can halt or reverse the course of chronic kidney disease with minimal side-effect burden on the patient. Small interfering RNA (siRNA) nanoparticles are new therapeutic entities in clinical development that could be useful for chronic kidney disease tre
PMID 25734248

[Significance of trace deposition of immunoglobulin M in glomerular mesangium in children with minimal change nephrotic syndrome].

Li ZH1, Xia TH, Duan CR, Wu TH, Xun M, Yin Y, Ding YF, Zhang Y, Zhang L.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics.Zhongguo Dang Dai Er Ke Za Zhi.2015 Mar;17(3):222-6.
OBJECTIVE: To study the significance of trace immunoglobulin M (IgM) deposits in glomerular mesangium in children with minimal change primary nephrotic syndrome (PNS).METHODS: One hundred and six children who were clinically diagnosed with PNS and pathologically diagnosed with minimal change disease
PMID 25815488

Japanese Journal

IgA Production and Tonsillar Focal Infection in IgA Nephropathy

Meng Hongxue,Ohtake Hiroya,Ishida Akihiro,Ohta Nobuo,Kakehata Seiji,Yamakawa Mitsunori
Journal of Clinical and Experimental Hematopathology 52(3), 161-170, 2012
… IgA nephropathy (IgAN), the common primary glomerulonephritis, is a tonsillar focal infection characterized by the qualitative abnormality of IgA in circulation and IgA deposition in the renal mesangium. … The favorable effect of tonsillectomy on patients with IgAN showed that tonsillar focal infection may be closely related to pIgA1 deposition in glomerular mesangium of patients with IgAN and at least a part of pIgA1 may originate from affected tonsils. …
NAID 130003322354

Distinct Distribution of the Tensin Family in the Mouse Kidney and Small Intestine

NISHINO Tomohiro,SASAKI Nobuya,CHIHARA Masataka,NAGASAKI Ken-ichi,TORIGOE Daisuke,KON Yasuhiro,AGUI Takashi
Experimental Animals 61(5), 525-532, 2012
… Murine mutations in the Tns1 and Tns2 genes cause polycystic kidney disease and glomerular sclerosis, respectively, and Tns3-null mice exhibit an impaired intestinal epithelial development. … Immunohistochemical staining revealed that Tns1 was predominantly localized to the mesangium of glomeruli and renal tubules. …
NAID 130001893579

Protective Effect of Stachybotrys microspora Triprenyl Phenol-7on the Deposition of IgA to the Glomerular Mesangium in Nivalenol-induced IgA Nephropathy Using BALB/c Mice

Kemmochi Sayaka,Hayashi Hitomi,Taniai Eriko,Hasumi Keiji,Sugita-Konishi Yoshiko,Kumagai Susumu,Mitsumori Kunitoshi,Shibutani Makoto
Journal of Toxicologic Pathology 25(2), 149-154, 2012
… Immunofluorescence analysis revealed an inhibitory effect of SMTP-7 on the glomerular deposition of IgA in Experiment 1; … These results suggest that SMTP-7 has a potential to decrease the progression of IgAN induced by NIV through inhibition of local accumulation of IgA in the glomerular mesangium, while it was ineffective for suppression of IgA production. …
NAID 130001884602