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N-Acetylgalactosamine

Sphingosine

A globoside is a type of glycosphingolipid with more than one sugar as the side chain (or R group) of ceramide. The sugars are usually a combination of N-acetylgalactosamine, D-glucose or D-galactose. A glycosphingolipid that has only one sugar as the side chain is called a cerebroside.

The side chain can be cleaved by galactosidases and glucosidases. The deficiency of α-galactosidase A causes Fabry's disease, an inherited metabolic disease characterized by the accumulation of the globoside globotriaosylceramide.

External links

Globosides at the US National Library of Medicine Medical Subject Headings (MeSH)

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English Journal

Globoside (Gb4) promotes activation of ERK by interaction with the epidermal growth factor receptor.

Park SY, Kwak CY, Shayman JA, Kim JH.SourceDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 305-701, Republic of Korea.
Biochimica et biophysica acta.Biochim Biophys Acta.2012 Apr 20. [Epub ahead of print]
BACKGROUND: Globoside (Gb4), a globo-series glycosphingolipid (GSL), has been characterized as a stage-specific embryonic antigen (SSEA), and is highly expressed during embryogenesis as well as in cancer tissues. However, the functional role and molecular mechanism of Gb4 are so far unknown.METHODS:
PMID 22542783

Changes in glycosphingolipid composition during differentiation of human embryonic stem cells to ectodermal or endodermal lineages.

Liang YJ, Yang BC, Chen JM, Lin YH, Huang CL, Cheng YY, Hsu CY, Khoo KH, Shen CN, Yu J.SourceInstitute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan.
Stem cells (Dayton, Ohio).Stem Cells.2011 Dec;29(12):1995-2004. doi: 10.1002/stem.750.
Glycosphingolipids (GSLs) are ubiquitous components of cell membranes that can act as mediators of cell adhesion and signal transduction and can possibly be used as cell type-specific markers. Our previous study indicated that there was a striking switch in the core structures of GSLs during differe
PMID 21956927

Japanese Journal

P系血液型とその抗体 (広範囲血液・尿化学検査免疫学的検査(第7版・3)その数値をどう読むか) -- (免疫学的検査血液型および輸血検査)

加藤俊明,石丸健,池田久實
日本臨床 68(-), 748-750, 2010-06
NAID 40017181886

Tamio Yamakawa : Dawn of Glycobiology

Suzuki Akemi
The journal of biochemistry 146(2), 149-156, 2009-08-01
NAID 10026302409

Studies on erythrocyte glycolipids

Yamakawa Tamio
Proceedings of the Japan Academy, Series B 81(2), 52-63, 2005
The discovery and structural identification of glycolipids in erythrocyte membranes by the author's research group are reviewed. Differences among species and individuals were the characteristic featu …
NAID 130000093811