WordNet

relating to or affecting or functioning as a gland; "glandular malfunctions"
any malignant tumor derived from epithelial tissue; one of the four major types of cancer

PrepTutorEJDIC

腺(せん)の;腺を冒す / 腺のある,腺から成る
がん,がん腫

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 肺癌が疑われる患者の初期評価、診断、および病期分類の概要 overview of the initial evaluation diagnosis and staging of patients with suspected lung cancer
2. The approach to ovarian cancer in older women
3. 上皮性卵巣癌、卵管癌、および腹膜癌：臨床的特徴および診断 epithelial carcinoma of the ovary fallopian tube and peritoneum clinical features and diagnosis
4. 頭頸部癌に対する治療の概要 overview of treatment for head and neck cancer
5. 原発不明癌の分類およびマネージメントの概要 overview of the classification and management of cancers of unknown primary site

English Journal

Hormonal regulation of beta-catenin during development of the avian oviduct and its expression in epithelial cell-derived ovarian carcinogenesis.

Bae SM, Lim W, Jeong W, Lee JY, Kim J, Han JY, Bazer FW, Song G.Author information WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.AbstractBeta-catenin (CTNNB1) is a dual function molecule that acts as a key component of the cadherin complex and WNT signaling pathway. It has a crucial role in embryogenesis, tumorigenesis, angiogenesis and progression of metastasis. Recently, it has been suggested that the CTNNB1 complex is a major regulator of development of the mouse oviduct and uterus. However, little is known about the CTNNB1 gene in chickens. Therefore, in this study, we focused on the CTNNB1 gene in the chicken reproductive tract and hormonal control of its expression in the chicken oviduct. CTNNB1 was localized specifically to the luminal and glandular epithelium of the four segments of chicken oviduct and DES (diethylstilbestrol, a synthetic non-steroidal estrogen) increased its expression primarily in LE of the magnum. In addition, CTNNB1 mRNA and protein were expressed abundantly in glandular epithelium of endometrioid-type ovarian carcinoma, but not in normal ovaries. Moreover, CTNNB1 expression was post-transcriptionally regulated via its 3'-UTR by binding with target miRNAs including miR-217, miR-1467, miR-1623 and miR-1697. Collectively, these results indicate that CTNNB1 is a novel gene regulated by estrogen in epithelial cells of the chicken oviduct and that it is also abundantly expressed in epithelial cells of endometrioid-type ovarian carcinoma suggesting that it could be used as a marker for diagnosis of ovarian cancer in laying hens and women.
Molecular and cellular endocrinology.Mol Cell Endocrinol.2014 Jan 25;382(1):46-54. doi: 10.1016/j.mce.2013.09.010. Epub 2013 Sep 18.
Beta-catenin (CTNNB1) is a dual function molecule that acts as a key component of the cadherin complex and WNT signaling pathway. It has a crucial role in embryogenesis, tumorigenesis, angiogenesis and progression of metastasis. Recently, it has been suggested that the CTNNB1 complex is a major regu
PMID 24055276

SATB2 is a Novel Marker of Osteoblastic Differentiation and Colorectal Adenocarcinoma.

Ordóñez NG.Author information Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX.AbstractSATB2 is a nuclear matrix-associated transcription factor and epigenetic regulator that is involved in osteoblastic differentiation and is also expressed in the glandular epithelial cells of the lower gastrointestinal tract. Recent studies have shown that, because of its relative specificity for osteoblastic differentiation, SATB2 immunostaining could potentially be a useful adjunct for assisting in the differential diagnosis of both benign and malignant osteogenic tumors. In addition, because SATB2 is also a highly sensitive and specific marker for colorectal adenocarcinomas, it could also serve as a complementary marker in the differential diagnosis of a carcinoma of unknown primary origin.
Advances in anatomic pathology.Adv Anat Pathol.2014 Jan;21(1):12-6. doi: 10.1097/PAP.0000000000000001.
SATB2 is a nuclear matrix-associated transcription factor and epigenetic regulator that is involved in osteoblastic differentiation and is also expressed in the glandular epithelial cells of the lower gastrointestinal tract. Recent studies have shown that, because of its relative specificity for ost
PMID 24316906

Mapping of succinate dehydrogenase losses in 2258 epithelial neoplasms.

Miettinen M, Sarlomo-Rikala M, McCue P, Czapiewski P, Langfort R, Waloszczyk P, Wazny K, Biernat W, Lasota J, Wang Z.Author information *Laboratory of Surgical Pathology, National Cancer Institute, Bethesda, MD †Department of Pathology/Haartman Institute and HusLab, Helsinki University Hospital, Helsinki, Finland ‡Department of Pathology and Cell Biology, Jefferson Medical College of Thomas Jefferson University and University Hospital, Philadelphia, PA §Department of Pathomorphology, Medical University of Gdansk, Gdansk ∥Department of Pathology, National Tuberculosis and Lung Diseases Research Institute, Warsaw ¶Independent Laboratory of Pathology, Zdunomed, Szczecin, Poland.AbstractLosses in the succinate dehydrogenase (SDH) complex characterize 20% to 30% of extra-adrenal paragangliomas and 7% to 8% of gastric GISTs, and rare renal cell carcinomas. This loss is reflected as lack of the normally ubiquitous immunohistochemical expression of the SDH subunit B (SDHB). In paragangliomas, SDHB loss correlates with homozygous loss of any of the SDH subunits, typically by loss-of-function mutations. The occurrence of SDHB losses in other epithelial malignancies is unknown. In this study, we immunohistochemically examined 2258 epithelial, mostly malignant neoplasms including common carcinomas of all sites. Among renal cell carcinomas, SDHB loss was observed in 4 of 711 cases (0.6%), including a patient with an SDHB-deficient GIST. Histologically, the SDHB-negative renal carcinomas varied. There was 1 clear cell carcinoma with a high nuclear grade, 1 papillary carcinoma type 2, 1 unclassified carcinoma with a glandular pattern, and 1 oncocytoid low-grade carcinoma as previously described for SDHB-negative renal carcinoma. None of these patients was known to have paragangliomas or had loss of SDHA expression in the tumor. Three of these patients had metastases at presentation (2 in the adrenal, 1 in the retroperitoneal lymph nodes). There were no cases with SDHB loss among 64 renal oncocytomas. SDHB losses were not seen in other carcinomas, except in 1 prostatic adenocarcinoma (1/57), 1 lymphoepithelial carcinoma of the stomach, and 1 (1/40) seminoma. On the basis of this study, SDHB losses occur in 0.6% of renal cell carcinomas and extremely rarely in other carcinomas. Some of these renal carcinomas may be clinically aggressive. The clinical significance and molecular genetics of these SDHB-negative tumors requires further study.
Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry.Appl Immunohistochem Mol Morphol.2014 Jan;22(1):31-6. doi: 10.1097/PAI.0b013e31828bfdd3.
Losses in the succinate dehydrogenase (SDH) complex characterize 20% to 30% of extra-adrenal paragangliomas and 7% to 8% of gastric GISTs, and rare renal cell carcinomas. This loss is reflected as lack of the normally ubiquitous immunohistochemical expression of the SDH subunit B (SDHB). In paragang
PMID 23531856

Japanese Journal

膵mixed ductal-neuroendocrine carcinomaの1例

渋谷一陽,蒲池浩文,敦賀陽介,若山顕治,折茂達也,柿坂達彦,横尾英樹,神山俊哉,三橋智子,武冨紹信
日本消化器外科学会雑誌 48(4), 337-343, 2015
… 理組織学的に分枝膵管内に進展する2.5 cmの白色充実性病変の中に，類円形に腫大した粗造なクロマチンを有する腫瘍細胞の髄様の増殖が見られた．腺管構造と粘液産生が見られductal cell carcinomaを認める一方，免疫染色検査では腫瘍の約1/3にchromogranin A（+），synaptophysin（+），CD56（+）の神経内分泌細胞の発現を認め，mixed ductal-neuroendocrine carcinomaの診断となった．本症例は非常にまれであり報告する． …
NAID 130005065287

乳腺腺様嚢胞癌の1例

神尾英則,神尾孝子,三浦弘子 [他],産形麻美子,野口英一郎,大地哲也,本田一穂,亀岡信悟
東京女子医科大学雑誌 84(E3), E435-E439, 2014-11-30
乳腺原発の腺様嚢胞癌の1例を経験したので、若干の文献的考察を加え報告する。症例は71歳女性。検診の乳腺超音波検査で左乳房乳頭直下やや外側下方に腫瘤を指摘され、精査目的に当科紹介となった。針組織生検で腺様嚢胞癌と診断され、乳房切除およびセンチネルリンパ節生検を施行した。病理組織所見では、間質を囲むように様々な大きさの蜂巣が、篩状構造や充実性構造を呈するように存在した。蜂巣には真の腺腔と偽嚢胞が認めら …
NAID 110009864204

Adenosquamous carcinoma of the conjunctiva: A case report

Kase Satoru,Yoshikawa Hiroshi,Nakajima Yutaka,Noda Mika,Ishida Susumu
Oncology Letters 7(6), 1941-1943, 2014-06
… Adenosquamous carcinoma (ASC) is a rare form of malignancy which consists of two types of cell, including squamous cells and glandular-like cells. … Histologically, the tumor was diagnosed as a squamous cell carcinoma. … A number of tumor cells demonstrated squamous differentiation with a keratinizing tendency, while other tumor cells exhibited mucin-producing activity with glandular formation. …
NAID 120005537460