giant platelet

WordNet

1. any creature of exceptional size
2. someone or something that is abnormally large and powerful (同)goliath, behemoth, monster, colossus
3. a very large person; impressive in size or qualities (同)hulk, heavyweight, whale
4. an imaginary figure of superhuman size and strength; appears in folklore and fairy tales
5. an unusually large enterprise; "Walton built a retail giant"
6. tiny bits of protoplasm found in vertebrate blood; essential for blood clotting (同)blood_platelet, thrombocyte

PrepTutorEJDIC

1. 『大男』;(物語・伝説の)『巨人』 / 『大人物』,偉人 / 『巨大な物』 / 巨大な,ものすごく大きい

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/11/14 12:28:44」(JST)

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Giant platelet disorder
Classification and external resources
Two giant platelets (stained purple) are visible in this image from a light microscope (40×) from a peripheral blood smear surrounded by red blood cells. One normal platelet can be seen in the upper left side of the image (purple) and is significantly smaller in size than the red blood cells (stained pink).
ICD-10	D69.1

Giant platelet disorders are rare disorders featuring abnormally large platelets, thrombocytopenia and a tendency to bleeding. Giant platelet disorder occurs for inherited diseases like Bernard-Soulier syndrome, gray platelet syndrome and May-Hegglin anomaly.

Giant platelet disorders can be further categorized :

• Caused by glycoprotein abnormalities: Bernard-Soulier syndrome, Velocardiofacial syndrome
• Caused by calpain defect: Montreal platelet syndrome
• Caused by alpha granules defect: Gray platelet syndrome
• Characterized by abnormal neutrophil inclusions: May-Hegglin anomaly, Sebastian syndrome
• With systemic manifestations: Hereditary macrothrombocytopenia with hearing loss, Epstein syndrome, Fechtner syndrome
• With no specific abnormalities: Mediterranean macrothrombocytopenia

References

UpToDate Contents

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• 1. 先天性および後天性血小板機能障害 congenital and acquired disorders of platelet function
• 2. 末梢血塗抹標本の評価 evaluation of the peripheral blood smear
• 3. 小児における血小板減少症の原因 causes of thrombocytopenia in children
• 4. 原因不明の血小板減少症を有する成人に対するアプローチ approach to the adult with unexplained thrombocytopenia
• 5. 嚢胞性線維症：肝胆道系疾患 cystic fibrosis hepatobiliary disease

English Journal

• The NFL-TBS.40-63 anti-glioblastoma peptide enters selectively in glioma cells by endocytosis.

• Lépinoux-Chambaud C, Eyer J.SourceLaboratoire Neurobiologie & Transgenese, LUNAM, UPRES EA-3143, Université d'Angers, Centre Hospitalier Universitaire, Bâtiment IBS-IRIS, 49033 Angers, France.
• International journal of pharmaceutics.Int J Pharm.2013 Oct 1;454(2):738-47. doi: 10.1016/j.ijpharm.2013.04.004. Epub 2013 Apr 17.
• Glioblastoma are the most frequent and aggressive tumour of the nervous system despite surgical resection associated with chemotherapy and radiotherapy. Recently, we showed that the NFL-TBS.40-63 peptide corresponding to the sequence of a tubulin-binding site of neurofilaments, enters selectively in
• PMID 23603097

• Calotropis gigantiea (L.) R. Br (Apocynaceae): A Phytochemical and Pharmacological Review.

• Kadiyala M, Ponnusankar S, Kannan E.Source(Department of Pharmacology, JSS College of pharmacy, Udhagamandalam - 643001, The Nilgiris, Tamilnadu, India). Electronic address: madhurikadiyala3@gmail.com.
• Journal of ethnopharmacology.J Ethnopharmacol.2013 Sep 5. pii: S0378-8741(13)00599-0. doi: 10.1016/j.jep.2013.08.045. [Epub ahead of print]
• ETHNOPHARMACOLOGICAL RELEVANCE: Calotropis gigantiea (L.) R. Br (Apocynaceae) commonly called as "crown flower" or "giant milk weed" is a well-known weed to many cultures for treating various disorders related to central nervous system, skin diseases, digestive system, respiratory system, reproducti
• PMID 24012528

Japanese Journal

• 先天性巨大血小板症の診断

• 國島 伸治
• 日本内科学会雑誌 98(7), 1593-1598, 2009-07-10
• 先天性巨大血小板症は先天的に巨大血小板と血小板減少症を呈する疾患群の総称である．従来，本疾患群は極めてまれであると考えられていたが，日常診療で十分遭遇する頻度で存在し，慢性あるいは難治性の特発性血小板減少性紫斑病と診断され不必要な治療を受ける症例が少なくないことが判っている．Bernard-Soulier症候群とMay-Hegglin異常に代表されるMYH9異常症が最も頻度が高い．先天性巨大血小板 …
• NAID 10025192926

• 多発性骨髄腫を合併した巨大縦隔脂肪腫様脂肪肉腫の1切除例

• 坂口 泰人,河野 朋哉,大野 暢宏,寺田 泰二
• 日本呼吸器外科学会雑誌 23(1), 81-85, 2009-01-15
• 症例は75歳男性.2ヵ月前より労作時呼吸困難を自覚し,胸部CTにて上縦隔から大動脈弓をはさむように前縦隔と中縦隔に進展し,気管を右側に圧排する脂肪濃度の巨大腫瘍を認めた.精査にて多発性骨髄腫の合併を認めたが,腫瘍による呼吸器症状が出現していることから,多発性骨髄腫の治療に先行し縦隔腫瘍摘出術を施行した.多発性骨髄腫のため,胸骨は脆弱で骨髄からの完全止血が困難であり,血小板減少症に対しては血小板輸血 …
• NAID 110007082112

• 血小板減少から新生児期に診断された Bernard-Soulier 症候群の1例

• 榊原 清一,沼田 修,竹内 一夫,小野塚 淳哉,小林 玲
• 日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 44(3), 761-765, 2008-08-20
• NAID 10023969526

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★リンクテーブル★

リンク元	「巨大血小板」
関連記事	「giant」

「巨大血小板」

　　[★]

英

giant platelet

関

血小板

「giant」

　　[★]

• adj.

• 巨大な

関

colossal、huge、hugely、mega、prodigious、vast