巨細胞膠芽腫
- 関
- glioblastoma、glioblastoma multiforme、grade IV astrocytoma
WordNet
- small room in which a monk or nun lives (同)cubicle
- a device that delivers an electric current as the result of a chemical reaction (同)electric cell
- a room where a prisoner is kept (同)jail cell, prison cell
- (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
- any small compartment; "the cells of a honeycomb"
- a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
- any creature of exceptional size
- someone or something that is abnormally large and powerful (同)goliath, behemoth, monster, colossus
- a very large person; impressive in size or qualities (同)hulk, heavyweight, whale
- an imaginary figure of superhuman size and strength; appears in folklore and fairy tales
- an unusually large enterprise; "Walton built a retail giant"
- a fast-growing malignant brain tumor composed of spongioblasts; nearly always fatal (同)spongioblastoma
PrepTutorEJDIC
- (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
- 『大男』;(物語・伝説の)『巨人』 / 『大人物』,偉人 / 『巨大な物』 / 巨大な,ものすごく大きい
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/06/13 16:21:45」(JST)
[Wiki en表示]
| Giant-cell glioblastoma |
|
Some glioblastomas, such as this giant-cell variant, are discrete firm masses which clinically and radiographically simulate metastatic carcinoma
|
| WHO Classification |
| Standard name |
Giant-cell glioblastoma |
| Structure |
Neuroepithelial tumors
└►Astrocytic tumors
└►Glioblastoma
└►Giant-cell glioblastoma |
| ICD-O Code & WHO Grade |
| ICD-O Code |
9441/3 |
| WHO Grade |
IV |
| Synonyms & Acronyms |
| Synonyms |
Monstrocellular sarcoma |
| Epidemiology |
| Incidence |
0.15/100,000/y
new cases/population/year |
| Age peak |
42 |
| M/F ratio |
1.6 |
| Prognosis |
| Mean overall survival |
12 months |
| Medicine WikiProject/Neurology task force |
The giant-cell glioblastoma is a histological variant of glioblastoma, presenting a prevalence of bizarre, multinucleated (more than 20 nuclei) giant (up to 400 μm diameter) cells.
It occasionally shows an abundant stromal reticulin network and presents a high frequency of TP53 gene mutations.[1][2]
Symptoms and signs are similar to those of the ordinary glioblastoma. Methodology of diagnosis and treatment are the same.
Prognosis is similar to the ordinary glioblastoma (about 12 months).[3] Some authors (see later) refer cases with a slightly better outcome.
Contents
- 1 Historical annotation
- 2 Epidemiology
- 2.1 Incidence
- 2.2 Age and sex distribution
- 3 Prognosis
- 4 See also
- 5 References
Historical annotation
The giant-cell glioblastoma was originally termed "monstrocellular sarcoma", because of its stromal reticulin network,[4][5] but the astrocytic nature of the tumor was firmly established through the consistent GFAP expression analysis.[6][7][8]
Epidemiology
Incidence
The giant-cell glioblastoma is a rare neoplasia: its incidence is less than 1% of all brain tumors. It represents up to 5% of glioblastomas.[9]
Age and sex distribution
The mean age at clinical presentation is 42. The age distribution includes children and has a wider range than other diffuse astrocytomas (diffuse WHO grade II astrocytoma, anaplastic astrocytoma, ordinary glioblastoma).[9][10][11]
The giant-cell glioblastoma affects males more frequently. (The M/F ratio is 1.6.)[1]
Prognosis
Most patients with giant-cell glioblastoma have unfavourable prognosis,[12] but some authors report clinical results slightly better than the ordinary glioblastoma,[13][14][15][16][17] in all probability because this variant seems less infiltrative, due to the nature of giant cells of this type.[1]
See also
- Glioblastoma
- WHO classification of the tumors of the central nervous system
- Grading of the tumors of the central nervous system
References
- ^ a b c Ohgaki H, Peraud A, Nakazato Y, Watanabe K, von Deimling A (2000). "Giant cell glioblastoma". In Kleihues P, Cavenee WK. Pathology and Genetics of Tumours of the Nervous System. Lyon: IARC. ISBN 92-832-2409-4. [page needed]
- ^ Macchi G. (2005) [1981]. Malattie del sistema nervoso. PICCIN Editore. ISBN 88-299-1739-7. [page needed]
- ^ DeAngelis LM, Loeffler JS, Adam N. Mamelak AN (2007). "Primary and Metastatic Brain Tumors". In Pazdur R, Coia LR, Hoskins WJ, Wagman LD. Cancer Management: A Multidisciplinary Approach (10th ed.). Retrieved 4 August 2009. (Subscription required (help)). [page needed]
- ^ Zulch KJ (1979). Histological Typing of Tumours of the Central Nervous System. Geneva: World Health Organization. ISBN 978-92-4-176021-8. OCLC 6845931. [page needed]
- ^ Zulch KJ (1986). Brain Tumors: Their Biology and Pathology (3rd ed.). Berlin Heidelberg: Springer Verlag. ISBN 978-0-387-10933-6. [page needed]
- ^ Jacque CM, Kujas M, Poreau A, et al. (March 1979). "GFA and S 100 protein levels as an index for malignancy in human gliomas and neurinomas". Journal of the National Cancer Institute. 62 (3): 479–83. ISSN 0027-8874. PMID 216839.
- ^ Kleihues P, Burger PC, Scheithauer BW (1993). Histological Typing of Tumours of the Central Nervous System (2nd ed.). Berlin Heidelberg: Springer Verlag. ISBN 978-3-540-56971-8. [page needed]
- ^ Russell DS, Rubinstein LJ (1989). Pathology of Tumors of the Nervous System (5th ed.). London: Edward Arnold. [page needed]
- ^ a b Palma L, Celli P, Maleci A, Di Lorenzo N, Cantore G (1989). "Malignant monstrocellular brain tumours. A study of 42 surgically treated cases". Acta Neurochirurgica. 97 (1–2): 17–25. ISSN 0001-6268. PMID 2718792. doi:10.1007/BF01577735.
- ^ Meyer-Puttlitz B, Hayashi Y, Waha A, et al. (September 1997). "Molecular genetic analysis of giant-cell glioblastomas". The American Journal of Pathology. 151 (3): 853–7. ISSN 0002-9440. PMC 1857850 . PMID 9284834.
- ^ Peraud A, Watanabe K, Plate KH, Yonekawa Y, Kleihues P, Ohgaki H (November 1997). "p53 mutations versus EGF receptor expression in giant-cell glioblastomas". Journal of Neuropathology and Experimental Neurology. 56 (11): 1236–41. ISSN 0022-3069. PMID 9370234. doi:10.1097/00005072-199711000-00008.
- ^ Huang MC, Kubo O, Tajika Y, Takakura K (April 1996). "A clinico-immunohistochemical study of giant cell glioblastoma" (Free full text). Nōshuyō Byōri. 13 (1): 11–6. ISSN 0914-8108. PMID 8916121.
- ^ Margetts JC, Kalyan-Raman UP (February 1989). "Giant-celled glioblastoma of brain. A clinico-pathological and radiological study of ten cases (including immunohistochemistry and ultrastructure)" (Free full text). Cancer. 63 (3): 524–31. ISSN 0008-543X. PMID 2912529. doi:10.1002/1097-0142(19890201)63:3<524::AID-CNCR2820630321>3.0.CO;2-D.
- ^ Shinojima N, Kochi M, Hamada J, et al. (August 2004). "The influence of sex and the presence of giant cells on postoperative long-term survival in adult patients with supratentorial glioblastoma multiforme". Journal of Neurosurgery. 101 (2): 219–26. ISSN 0022-3085. PMID 15309911. doi:10.3171/jns.2004.101.2.0219.
- ^ Becker DP, Benyo R, Roessmann U (January 1967). "Glial origin of monstrocellular tumor. Case report of prolonged survival" (Free full text). Journal of Neurosurgery. 26 (1): 72–7. ISSN 0022-3085. PMID 6018784. doi:10.3171/jns.1967.26.1part1.0072.
- ^ Burger PC, Vollmer RT (September 1980). "Histologic factors of prognostic significance in the glioblastoma multiforme" (Free full text). Cancer. 46 (5): 1179–86. ISSN 0008-543X. PMID 6260329. doi:10.1002/1097-0142(19800901)46:5<1179::AID-CNCR2820460517>3.0.CO;2-0.
- ^ Klein R, Mölenkamp G, Sörensen N, Roggendorf W (June 1998). "Favorable outcome of giant cell glioblastoma in a child. Report of an 11-year survival period". Child's Nervous System. 14 (6): 288–91. ISSN 0256-7040. PMID 9694343. doi:10.1007/s003810050228.
|
Nervous tissue tumors/NS neoplasm/Neuroectodermal tumor (ICD-O 9350–9589) (C70–C72, D32–D33, 191–192/225)
|
| Endocrine |
| Sellar: |
- Craniopharyngioma
- Pituicytoma
|
| Other: |
|
|
| CNS |
Neuroepithelial
(brain tumors,
spinal tumors) |
| Glioma |
| Astrocyte |
- Astrocytoma
- Pilocytic astrocytoma
- Pleomorphic xanthoastrocytoma
- Subependymal giant cell astrocytoma
- Fibrillary astrocytoma
- Anaplastic astrocytoma
- Glioblastoma multiforme
|
| Oligodendrocyte |
|
| Ependyma |
|
| Choroid plexus |
- Choroid plexus tumor
- Choroid plexus papilloma
- Choroid plexus carcinoma
|
| Multiple/unknown |
- Oligoastrocytoma
- Gliomatosis cerebri
- Gliosarcoma
|
|
Mature
neuron |
- Ganglioneuroma: Ganglioglioma
- Retinoblastoma
- Neurocytoma
- Dysembryoplastic neuroepithelial tumour
- Lhermitte–Duclos disease
|
| PNET |
- Neuroblastoma
- Esthesioneuroblastoma
- Ganglioneuroblastoma
- Medulloblastoma
- Atypical teratoid rhabdoid tumor
|
| Primitive |
|
|
Meningiomas
(Meninges) |
- Meningioma
- Hemangiopericytoma
|
| Hematopoietic |
- Primary central nervous system lymphoma
|
|
| PNS: NST |
- Cranial and paraspinal nerves: Neurofibroma
- Neurofibrosarcoma
- Neurofibromatosis
- Neurilemmoma/Schwannoma
- Malignant peripheral nerve sheath tumor
|
|
Note: Not all brain tumors are of nervous tissue, and not all nervous tissue tumors are in the brain (see brain metastasis).
|
UpToDate Contents
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English Journal
- Phase II trial of irinotecan and metronomic temozolomide in patients with recurrent glioblastoma.
- Reynés G1, Martínez-Sales V, Vila V, Balañá C, Pérez-Segura P, Vaz MA, Benavides M, Gallego O, Palomero I, Gil-Gil M, Fleitas T, Reche E.
- Anti-cancer drugs.Anticancer Drugs.2016 Feb;27(2):133-7. doi: 10.1097/CAD.0000000000000314.
- This phase II study was conducted to determine the efficacy and safety of metronomic temozolomide (TMZ) in combination with irinotecan in glioblastoma (GB) at first relapse. Patients with GB at first relapse received TMZ 50 mg/m/day divided into three doses, except for a single 100 mg/m dose, ad
- PMID 26574999
- Development of next generation adeno-associated viral vectors capable of selective tropism and efficient gene delivery.
- Zhang C1, Yao T1, Zheng Y1, Li Z1, Zhang Q1, Zhang L1, Zhou D2.
- Biomaterials.Biomaterials.2016 Feb;80:134-45. doi: 10.1016/j.biomaterials.2015.11.066. Epub 2015 Dec 2.
- Virus-based nanoparticles have shown promise as vehicles for delivering therapeutic genes. However, the rational design of viral vectors that enable selective tropism towards particular types of cells and tissues remains challenging. Here, we explored structural-functional relationships of the adeno
- PMID 26708090
- Collaboration of 3D context and extracellular matrix in the development of glioma stemness in a 3D model.
- Ma NK1, Lim JK1, Leong MF2, Sandanaraj E3, Ang BT4, Tang C5, Wan AC6.
- Biomaterials.Biomaterials.2016 Feb;78:62-73. doi: 10.1016/j.biomaterials.2015.11.031. Epub 2015 Nov 26.
- A hierarchy of cellular stemness exists in certain cancers, and any successful strategy to treat such cancers would have to eliminate the self-renewing tumor-initiating cells at the apex of the hierarchy. The cellular microenvironment, in particular the extracellular matrix (ECM), is believed to hav
- PMID 26684838
Japanese Journal
- 症例 転移性脳腫瘍との鑑別が困難であった巨細胞膠芽腫の一例
- CD98 immunoreactivity in multinucleated giant cells of glioblastomas: An immunohistochemical double labeling study
- TAKEUCHI Hiroaki,KUBOTA Toshihiko,KITAI Ryuhei,NAKAGAWA Takao,HASHIMOTO Norichika
- Neuropathology : official journal the Japanese Society of Neuropathology 28(2), 127-131, 2008-04-01
- NAID 10025824456
- 巨細胞性脳腫瘍における巨細胞についての形態学的解析
- 李 強,大重 英行,甄 云波 [他],山原 崇弘,大石 哲也,瀬野 敏孝,川口 琢也,李 一,河本 圭司
- Neuro-oncologyの進歩 17(1), 22-28, 2008
- … Although giant cells are often picked up in various brain tumors, the giant cell brain tumor is defined as giant cells inhabit the majority of the brain tumor. …
- NAID 130001933531
Related Links
- WHO グレード4 の悪性腫瘍 グリオブラストーマ，業界用語で グリブラ といいます 英語では GBM (glioblastoma multiforme) ジービーエム といいます 脳の神経細胞を支える神経膠細胞（星細胞，グリア）が腫瘍化したものです 大脳に発生 ...
- Glioblastoma (grade IV), IDH wild-type 膠芽腫 IDH変異なし Giant cell glioblastoma (grade IV) 巨細胞性膠芽腫 Gliosarcoma (grade IV) 膠肉腫 Epithelioid glioblastoma (grade IV) 類上皮性膠芽腫 Glioblastoma, IDH mut ant 膠芽 ...
Related Pictures
★リンクテーブル★
[★]
- 英
- giant cell glioblastoma
- 関
- グリア芽細胞腫、多形神経膠芽腫、グレードIV星細胞腫
[★]
グレードIV星細胞腫
- 関
- giant cell glioblastoma、glioblastoma、glioblastoma multiforme
[★]
- 関
- colossal、huge、hugely、mega、prodigious、vast
[★]
細胞
