geranylgeranyl pyrophosphate synthase

ゲラニルゲラニルピロリン酸合成酵素、ゲラニルゲラニルピロリン酸シンターゼ

関

geranylgeranyl-diphosphate geranylgeranyltransferase

WordNet

1. a salt or ester of pyrophosphoric acid

UpToDate Contents

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• 1. 肝グリコーゲン合成酵素欠損症（糖原病0型） liver glycogen synthase deficiency glycogen storage disease 0
• 2. ピロリン酸カルシウム結晶沈着症（CPPD）の治療 treatment of calcium pyrophosphate crystal deposition cppd disease
• 3. ピロリン酸カルシウム結晶沈着症（CPPD）の臨床症状および診断 clinical manifestations and diagnosis of calcium pyrophosphate crystal deposition cppd disease
• 4. ピロリン酸カルシウム結晶沈着症（CPPD）の発症および病因 pathogenesis and etiology of calcium pyrophosphate crystal deposition cppd disease
• 5. 低アルドステロン症（4型RTA）の病因、診断、および治療 etiology diagnosis and treatment of hypoaldosteronism type 4 rta

English Journal

• Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice.

• Yang J, Mou Y, Wu T, Ye Y, Jiang JC, Zhao CZ, Zhu HH, Du CQ, Zhou L, Hu SJ.SourceInstitute of Cardiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, No.79, Qing-Chun Road, Hangzhou 310003, China.
• Cardiovascular research.Cardiovasc Res.2013 Mar 1;97(3):490-9. doi: 10.1093/cvr/cvs347. Epub 2012 Nov 24.
• AIMS: Farnesyl pyrophosphate synthase (FPPS) is a key enzyme in the mevalonate pathway. In our previous study, we found that inhibition of FPPS attenuates cardiac hypertrophy in spontaneously hypertensive rats (SHRs) and prevents angiotensin (Ang) II-induced hypertrophy in cardiomyocytes. Here, we f
• PMID 23180723

• Functional characterization of three Coffea arabica L. monoterpene synthases: Insights into the enzymatic machinery of coffee aroma.

• Del Terra L, Lonzarich V, Asquini E, Navarini L, Graziosi G, Suggi Liverani F, Pallavicini A.Sourceillycaffè SpA, via Flavia 110, 34147 Trieste, Italy. Electronic address: lorenzo.delterra@illy.com.
• Phytochemistry.Phytochemistry.2013 Feb 8. pii: S0031-9422(13)00027-7. doi: 10.1016/j.phytochem.2013.01.005. [Epub ahead of print]
• The chemical composition of the coffee beverage is extremely complex, being made up of hundreds of volatile and non-volatile compounds, many of which are generated in the thermal reactions that occur during the roasting process. However, in the raw coffee bean there are also compounds that survive r
• PMID 23398891

• Molecular cloning and characterization of GbDXS and GbGGPPS gene promoters from Ginkgo biloba.

• Xu F, Huang XH, Li LL, Deng G, Cheng H, Rong XF, Li JB, Cheng SY.SourceCollege of Horticulture and Gardening, Yangtze University, Jingzhou, Hubei, China.
• Genetics and molecular research : GMR.Genet Mol Res.2013 Feb 4;12(1):293-301. doi: 10.4238/2013.February.4.3.
• Ginkgolides are key pharmaceutical components in Ginkgo biloba leaves. 1-Deoxy-D-xylulose-5-phosphate synthase (GbDXS) and geranylgeranyl pyrophosphate (GbGGPPS) genes are critical genes involved in ginkgolide biosynthesis. In this study, the promoters of GbDXS and GGPPS, with 676 and 570 bp in
• PMID 23408416

Japanese Journal

• Pitavastatin Decreases Tau levels Via the Inactivation of Rho/ROCK

• HAMANO Tadanori,YEN Shu-Hui,GENDRON Tania,KO Li-wen,KURIYAMA Masaru
• Neurobiology of Aging 33, 2011-11
• … The decrease caused by pitavastatin is reversed by the addition of mevalonate, or geranylgeranyl pyrophosphate. … The maturation of small G proteins, including RhoA was disrupted by pitavastatin, as was the activity of glycogen synthase kinase 3β (GSK3β), a major tau kinase. … Rho kinase inhibitor also inactivated glycogen synthase kinase 3β. …
• NAID 120003593722

• 骨芽細胞増殖,分化におけるGGPP-RhoカスケードとGGPP synthaseの役割 (第7回日本骨粗鬆症学会 一般演題Highlight)

• 吉田 知彦
• オステオポローシスジャパン 14(2), 260-263, 2006
• NAID 40007315193

• The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding

• KAVANAGH K. L.
• J. Biol. Chem. 281, 22004-22012, 2006
• NAID 30016367391

Related Links

• Geranylgeranyl pyrophosphate synthase (Q12051)

Identification Name: Geranylgeranyl pyrophosphate synthase Synonyms GGPP synthase GGPPSase BET2 suppressor protein 1 Geranylgeranyl diphosphate synthase Dimethylallyltranstransferase Geranyltranstransferase

• Entry Page < Enzyme Portal < EMBL-EBI

Geranylgeranyl pyrophosphate synthase, chloroplastic; GGPP synthase; GGPS; EC 2.5.1.-; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; EC 2.5.1.1; Farnesyl diphosphate synthase; EC 2.5.1.29; ...

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★リンクテーブル★

リンク元	「ゲラニルゲラニルピロリン酸合成酵素」「geranylgeranyl-diphosphate geranylgeranyltransferase」「ゲラニルゲラニルピロリン酸シンターゼ」
関連記事	「synthase」「pyrophosphate」

「ゲラニルゲラニルピロリン酸合成酵素」

　　[★]

英

geranylgeranyl pyrophosphate synthase

関

ゲラニルゲラニル二リン酸ゲラニルゲラニルトランスフェラーゼ、ゲラニルゲラニルピロリン酸シンターゼ

「geranylgeranyl-diphosphate geranylgeranyltransferase」

　　[★]

ゲラニルゲラニル二リン酸ゲラニルゲラニルトランスフェラーゼ

関

geranylgeranyl pyrophosphate synthase

「ゲラニルゲラニルピロリン酸シンターゼ」

　　[★]

英

geranylgeranyl pyrophosphate synthase

関

ゲラニルゲラニルピロリン酸合成酵素

「synthase」

　　[★]

• n.

• (脱離酵素リアーゼの逆反応である合成方向の反応を指す) シンターゼ, 合成酵素, 付加酵素

関

lyase、synthetase、transferase

「pyrophosphate」

　　[★] ピロリン酸、二リン酸

関

bisphosphate、diphosphate、diphosphoric acid、PPi