ノックアウトマウス。標的遺伝子破壊マウス
WordNet
- manipulate the mouse of a computer
- a hand-operated electronic device that controls the coordinates of a cursor on your computer screen as you move it around on a pad; on the bottom of the device is a ball that rolls on the surface of the pad; "a mouse takes much more room than a trackball" (同)computer mouse
- any of numerous small rodents typically resembling diminutive rats having pointed snouts and small ears on elongated bodies with slender usually hairless tails
- person who is quiet or timid
- (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
- informal term for information; "give me the gen on your new line of computers"
PrepTutorEJDIC
- 『ハツカネズミ』(英米の家によく出没する小型のネズミ;ほが国の家に出没する大型のネズミはrat) / 《話》臆病者,内気な人 / 《猫が》ネズミを捜す(捕らえる) / 《人が》(…を)あさり歩く《+『about』+『名』》
- 遺伝子
UpToDate Contents
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English Journal
- miR-199a-3p is involved in estrogen-mediated autophagy through the IGF-1/mTOR pathway in osteocyte-like MLO-Y4 cells.
- Fu J1, Hao L1, Tian Y1, Liu Y1, Gu Y1, Wu J1.
- Journal of cellular physiology.J Cell Physiol.2018 Mar;233(3):2292-2303. doi: 10.1002/jcp.26101. Epub 2017 Aug 25.
- PMID 28708244
- Ptn functions downstream of C/EBPβ to mediate the effects of cAMP on uterine stromal cell differentiation through targeting Hand2 in response to progesterone.
- Yu HF1, Tao R2, Yang ZQ1, Wang K1, Yue ZP1, Guo B1.
- Journal of cellular physiology.J Cell Physiol.2018 Feb;233(2):1612-1626. doi: 10.1002/jcp.26067. Epub 2017 Jul 24.
- PMID 28657144
- MicroRNA-224-5p regulates adipocyte apoptosis induced by TNFα via controlling NF-κB activation.
- Qi R1,2, Huang J1,2, Wang Q1, Liu H1, Wang R2, Wang J1, Yang F1.
- Journal of cellular physiology.J Cell Physiol.2018 Feb;233(2):1236-1246. doi: 10.1002/jcp.25992. Epub 2017 Jun 9.
- PMID 28488777
Japanese Journal
- Long-term in vivo gene expression in mouse kidney using φC31 integrase and electroporation
- Otani Yuki,Kawakami Shigeru,Mukai Hidefumi,Fuchigami Yuki,Yamashita Fumiyoshi,Hashida Mitsuru
- Journal of Drug Targeting
- … Background: Achieving long-term gene expression in kidney will be beneficial for gene therapy of renal and congenital diseases, genetic studies constructing animal disease models, and the functional analysis of disease-related genes. … Purpose: The purpose of this study was to develop an in vivo long-term gene expression system in murine kidney using φC31 integrase. … Methods: Gene expression in cultured RENCA, TCMK-1, and HEK293 cells was assessed. …
- NAID 120005621902
- Exploring the Regulatory Mechanism of Stress Responses in the Paraventricular Nucleus of the Hypothalamus: Backgrounds and Future Perspectives of Corticotropin-Releasing Factor-Modified Yellow Fluorescent Protein-Knock-In Mouse
- ITOI Keiichi
- Interdisciplinary Information Sciences 21(3), 213-224, 2015
- … In order to unravel unsolved issues underlying the regulatory mechanisms for CRF neurons, modified yellow fluorescent protein (Venus) gene was inserted into the CRF gene in frame, and CRF neurons were visualized by the Venus fluorescence. … This mouse is a useful tool especially for conducting electrophysiological recordings from CRF neurons. …
- NAID 130005097996
- 化学療法抵抗性卵巣癌の局所免疫の解析に基づいた,がん免疫逃避を標的とした新規治療戦略(シンポジウム2(腫瘍) 難治性卵巣癌の克服を目指して,第66回日本産科婦人科学会学術講演会講演要旨)
- 濱西 潤三
- 日本産科婦人科學會雜誌 66(11), 2777-2791, 2014-11-01
- … In addition, using a syngenic mouse ovarian cancer model, we investigated whether inhibition of the PD-1/PD-L1 signal can induce an anti-tumor effect in a clinical setting and increase the efficacy of chemotherapy. … Method: First, we attempted to explore the status of local immunity in ovarian cancers by integrating various immunological parameters, determined by immunohistochemical analysis of clinical specimens, and validated these results in a mouse ovarian cancer model. …
- NAID 110009872637
Related Links
- 1. Methods Mol Biol. 2011;770:293-312. doi: 10.1007/978-1-61779-210-6_11. Gene targeting in the mouse. Griep AE(1), John MC, Ikeda S, Ikeda A. Author information: (1)Department of Cell and Regenerative ...
- Customized for Your Research Established in 1998, ingenious targeting laboratory is a leading global mouse gene targeting company. We utilize cutting edge technologies from our mouse model toolbox, provide in depth scientific ...
★リンクテーブル★
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- 英
- knockout mouse
- 同
- 標的遺伝子破壊マウス gene targeting mouse
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- 英
- gene targeting mouse
- 関
- ノックアウトマウス
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ターゲティング、標的指向化