ホルムイミノグルタミン酸
- 同
- FIGLU
WordNet
- street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
- any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
- having the characteristics of an acid; "an acid reaction"
PrepTutorEJDIC
- 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/15 06:55:35」(JST)
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Formiminoglutamic acid
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| Names |
| IUPAC name
N-(aminomethylidene)-L-glutamic acid
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| Other names
FIGLU
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| Identifiers |
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CAS Number
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816-90-0 Y |
| ChemSpider |
388370 N |
| Jmol 3D model |
Interactive image |
| MeSH |
Formiminoglutamic+acid |
| PubChem |
909 |
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| Properties |
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Chemical formula
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C6H10N2O4 |
| Molar mass |
174.155 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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| N verify (what is YN ?) |
| Infobox references |
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Formiminoglutamic acid (FIGLU) is an intermediate in the metabolism of histidine.
The "FIGLU" test is used to identify deficiency of vitamin B12 or folate deficiency or liver disease.
See also
- Imidazol-4-one-5-propionic acid
- Glutamate-1-semialdehyde
- Formiminotransferase cyclodeaminase
- Glutamic acid
External links
- FIGLU Test at the US National Library of Medicine Medical Subject Headings (MeSH)
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Amino acid metabolism metabolic intermediates
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| K→acetyl-CoA |
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lysine→
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- Saccharopine
- Allysine
- α-Aminoadipic acid
- α-Ketoadipate
- Glutaryl-CoA
- Glutaconyl-CoA
- Crotonyl-CoA
- β-Hydroxybutyryl-CoA
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leucine→
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- α-Ketoisocaproic acid
- β-hydroxy β-methylbutyrate
- Isovaleryl-CoA
- 3-Methylcrotonyl-CoA
- 3-Methylglutaconyl-CoA
- HMG-CoA
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tryptophan→alanine→
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- N'-Formylkynurenine
- Kynurenine
- Anthranilic acid
- 3-Hydroxykynurenine
- 3-Hydroxyanthranilic acid
- 2-Amino-3-carboxymuconic semialdehyde
- 2-Aminomuconic semialdehyde
- 2-Aminomuconic acid
- Glutaryl-CoA
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| G |
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G→pyruvate→citrate
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glycine→serine→
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- glycine→creatine: Glycocyamine
- Phosphocreatine
- Creatinine
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G→glutamate→
α-ketoglutarate
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histidine→
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- Urocanic acid
- Imidazol-4-one-5-propionic acid
- Formiminoglutamic acid
- Glutamate-1-semialdehyde
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proline→
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- 1-Pyrroline-5-carboxylic acid
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arginine→
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- Agmatine
- Ornithine
- Cadaverine
- Putrescine
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other
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- cysteine+glutamate→glutathione: γ-Glutamylcysteine
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G→propionyl-CoA→
succinyl-CoA
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valine→
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- α-Ketoisovaleric acid
- Isobutyryl-CoA
- Methacrylyl-CoA
- 3-Hydroxyisobutyryl-CoA
- 3-Hydroxyisobutyric acid
- 2-Methyl-3-oxopropanoic acid
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isoleucine→
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- 2,3-Dihydroxy-3-methylpentanoic acid
- 2-Methylbutyryl-CoA
- Tiglyl-CoA
- 2-Methylacetoacetyl-CoA
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methionine→
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- generation of homocysteine: S-Adenosyl methionine
- S-Adenosyl-L-homocysteine
- Homocysteine
- conversion to cysteine: Cystathionine
- alpha-Ketobutyric acid+Cysteine
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threonine→
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propionyl-CoA→
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G→fumarate
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phenylalanine→tyrosine→
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- 4-Hydroxyphenylpyruvic acid
- Homogentisic acid
- 4-Maleylacetoacetic acid
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G→oxaloacetate
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| Other |
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UpToDate Contents
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English Journal
- Systems level metabolic phenotype of methotrexate administration in the context of non-alcoholic steatohepatitis in the rat.
- Kyriakides M1, Hardwick RN2, Jin Z3, Goedken MJ4, Holmes E1, Cherrington NJ2, Coen M5.
- Toxicological sciences : an official journal of the Society of Toxicology.Toxicol Sci.2014 Nov;142(1):105-16. doi: 10.1093/toxsci/kfu160. Epub 2014 Aug 21.
- Adverse drug reactions (ADRs) represent a significant clinical challenge with respect to patient morbidity and mortality. We investigated the hepatotoxicity and systems level metabolic phenotype of methotrexate (MTX) in the context of a prevalent liver disease; non-alcoholic steatohepatitis (NASH).
- PMID 25145655
- Formiminoglutamase from Trypanosoma cruzi is an arginase-like manganese metalloenzyme.
- Hai Y1, Dugery RJ, Healy D, Christianson DW.
- Biochemistry.Biochemistry.2013 Dec 23;52(51):9294-309. doi: 10.1021/bi401352h. Epub 2013 Nov 21.
- The crystal structure of formiminoglutamase from Trypanosoma cruzi (TcFIGase) is reported at 1.85 Å resolution. Although the structure of this enzyme was previously determined by the Structural Genomics of Pathogenic Protozoa Consortium (PDB accession code 2A0M), this structure was determined at lo
- PMID 24261485
- The origin and ecological significance of multiple branches for histidine utilization in Pseudomonas aeruginosa PAO1.
- Gerth ML1, Ferla MP, Rainey PB.
- Environmental microbiology.Environ Microbiol.2012 Aug;14(8):1929-40. doi: 10.1111/j.1462-2920.2011.02691.x. Epub 2012 Jan 9.
- Pseudomonas proliferate in a wide spectrum of harsh and variable environments. In many of these environments, amino acids, such as histidine, are a valuable source of carbon, nitrogen and energy. Here, we demonstrate that the histidine uptake and utilization (hut) pathway of Pseudomonas aeruginosa P
- PMID 22225844
Japanese Journal
- Quantification of urinary zwitterionic organic acids using weak-anion exchange chromatography with tandem MS detection
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 848(2), 303-310, 2007-04-01
- NAID 10025794009
- マススクリーニングにて発見されたヒスチジン血症の検討
- Megaloblastic anemia in Japan
Related Links
- Formiminoglutamic acidに関するウェブ上の情報を探す English Formiminoglutamic acidに関してgoo 辞書で探す Formiminoglutamic acidに関する画像を探す English Formiminoglutamic acidに関するニュースを探す ...
- formiminoglutamic acid /for·mim·i·no·glu·tam·ic ac·id/ (FIGLU) (for-mim″ĭ-no-gloo-tam´ik) an intermediate in the catabolic pathway from histidine to glutamate; it may be excreted in the urine in liver disease, vitamin B12 or folic acid ...
★リンクテーブル★
[★]
- 英
- formiminoglutamic acid, FIGLU
- 関
- 胃切除後葉酸欠乏症