flare up

　

WordNet

1. ignite quickly and suddenly, especially after having died down; "the fire flared up and died down once again"
2. used up; "time is up"
3. raise; "up the ante"
4. extending or moving toward a higher place; "the up staircase"; "a general upward movement of fish" (同)upward
5. to a later time; "they moved the meeting date up"; "from childhood upward" (同)upwards, upward
6. spatially or metaphorically from a lower to a higher position; "look up!"; "the music surged up"; "the fragments flew upwards"; "prices soared upwards"; "upwardly mobile" (同)upwards, upward, upwardly
7. (used of computers) operating properly; "how soon will the computers be up?"
8. (usually followed by `on or `for'
9. being or moving higher in position or greater in some value; being above a former position or level; "the anchor is up"; "the sun is up"; "he lay face up"; "he is up by a pawn"; "the market is up"; "the corn is up"
10. nearer to the speaker; "he walked up and grabbed my lapels"
11. open; "the windows are up"
12. to a higher intensity; "he turned up the volume"
13. to a more central or a more northerly place; "was transferred up to headquarters"; "up to Canada for a vacation"
14. burn brightly; "Every star seemed to flare with new intensity" (同)flame up, blaze up, burn up
15. a shape that spreads outward; "the skirt had a wide flare" (同)flair
16. a sudden burst of flame
17. a sudden recurrence or worsening of symptoms; "a colitis flare"; "infection can cause a lupus flare"
18. am unwanted reflection in an optical system (or the fogging of an image that is caused by such a reflection)
19. reddening of the skin spreading outward from a focus of infection or irritation
20. (baseball) a fly ball hit a short distance into the outfield
21. a device that produces a bright light for warning or illumination or identification
22. a burst of light used to communicate or illuminate (同)flash
23. a sudden outburst of emotion; "she felt a flare of delight"; "she could not control her flare of rage"
24. shine with a sudden light; "The night sky flared with the massive bombardment" (同)flame
25. (chiefly British) of or appropriate to the upper classes especially in language use

PrepTutorEJDIC

1. 《上への動作》『上へ』,上のほうへ / 《上の位置》『上に』,上のほうで / 『起こして』,立てて,直立して / (地図・紙面などの)『上へ(に)』,北のほうへ(に) / (遠くから)『近くへ,中心へ』;(周辺から)中心へ;(川下から)川上へ;(地方から)都会へ / (大きさ・量・価値・地位などが)『上のほうへ』,高く / (話者,話題の場所へ)『近づいて』,追いついて / 『活動して』,活動状態に / (物事・人が)現れて・起こって / 『すっかり』,完全に,終わって,…し尽くして / 保管(貯蔵)して;くるんだ(閉ざした)状態に / 《動詞を省略した命令文で》 / (野球・クリケットで)打席へ / (競技で)勝ち越して / (対抗の競技で)おのおの / 《移動・位置》『…の高いほうへ』,をのぼって;…の上のほうに / (川の)『上流へ』;(流れ・風)に逆らって;…の内陸(奥地)のほうへ / (自分が今いる所,またはある地点から前方へ)『…に沿って』 / 『上へ向かう』,(列車などが)上りの;上り坂の,(情勢などが)上向きの / 上り,上昇,上り坂 / 上昇気運,向上,幸運 / 上りの列車(バス・エレボーターなど) / 値上がり / …‘を'持ち上げる / …‘を'増大する,〈賃金・物価など〉‘を'引き上げる / 〈人〉‘を'昇進させる / 立ち上がる,起き上がる / 《and を伴って》急に(突然)…する
2. (風などで)〈炎が〉ゆらゆら燃える / 〈怒りなどが〉急に燃え上がえる / (らっぱの口のように)外に向かって開く;〈スカートが〉フレアになっている / 〈U〉ぱっと燃え上がる炎(光) / 〈C〉照明装置;照明弾 / 〈C〉《単数形で》(感情などの)ほとばしり.爆発《+『of』+『名』》 / 〈U〉(らっぱの口のような)(…の)末広がり《+『of』+『名』》
3. (ズボンやスカートが)すその広がった,フレアの
4. らっぱズボン

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• 1. 関節リウマチおよび妊娠 rheumatoid arthritis and pregnancy
• 2. 成人における再発および抵抗性皮膚筋炎と多発性筋炎の治療 treatment of recurrent and resistant dermatomyositis and polymyositis in adults
• 3. 成人における関節吸引または注射：手技および適応 joint aspiration or injection in adults technique and indications
• 4. リウマチ性疾患患者の術前評価および周術期マネージメント preoperative evaluation and perioperative management of patients with rheumatic diseases
• 5. 炎症性腸疾患の肺合併症 pulmonary complications of inflammatory bowel disease

English Journal

• The impact of cytomegalovirus reactivation and its treatment on the course of inflammatory bowel disease.

• Delvincourt M1, Lopez A, Pillet S, Bourrier A, Seksik P, Cosnes J, Carrat F, Gozlan J, Beaugerie L, Roblin X, Peyrin-Biroulet L, Sokol H.Author information 1Department of Gastroenterology, Saint Antoine Hospital, Assistance Publique Hôpitaux de Paris and Paris VI University, Paris, France.AbstractBACKGROUND: Consequences of latent cytomegalovirus (CMV) infection reactivation on inflammatory bowel disease (IBD) flare, as a flare-worsening factor or simple bystander, are debated. Impact of anti-viral treatment on IBD course is poorly known.
• Alimentary pharmacology & therapeutics.Aliment Pharmacol Ther.2014 Apr;39(7):712-20. doi: 10.1111/apt.12650. Epub 2014 Feb 9.
• BACKGROUND: Consequences of latent cytomegalovirus (CMV) infection reactivation on inflammatory bowel disease (IBD) flare, as a flare-worsening factor or simple bystander, are debated. Impact of anti-viral treatment on IBD course is poorly known.AIM: To assess the impact of CMV reactivation on patie
• PMID 24506221

• An analytical strategy to characterize the pharmacokinetics and pharmacodynamics of triptorelin in rats based on simultaneous LC-MS/MS analysis of triptorelin and endogenous testosterone in rat plasma.

• Han J1, Zhang S, Liu W, Leng G, Sun K, Li Y, Di X.Author information 1Laboratory of Drug Metabolism and Pharmacokinetics, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China.AbstractTriptorelin, a gonadotropin-releasing hormone agonist, has been used in the treatment of hormone-responsive prostate cancer by inducing testosterone suppression. Research on the relationship between the time courses of triptorelin and testosterone is very important, but accurate quantification of triptorelin and testosterone simultaneously in biological specimens is a challenging analytical problem. In the present study, a rapid, sensitive, and selective method for simultaneous determination of triptorelin and testosterone in rat plasma by solid-phase extraction and liquid chromatography-tandem mass spectrometry was developed using a ZORBAX RRHD Eclipse Plus C8 column (2.1 × 50 mm, 1.8 μm) with a 0.05 % propionic acid/methanol gradient. In view of the polarity difference between the two analytes, two internal standards, i.e., leuprolide and testosterone-(13)C3, were used for individual quantitation of triptorelin and testosterone. Endogenous testosterone was determined by reference to a calibration curve prepared using testosterone-D3 as a surrogate analyte. The method exhibits excellent linearity over three orders of magnitude for each analyte. The lower limit of quantification was 0.01 ng/mL for triptorelin and 0.05 ng/mL for testosterone, with consumption of 100 μL of plasma. The method was successfully applied to characterize the pharmacokinetics and pharmacodynamics of slow-release 28-day form triptorelin acetate biodegradable microspheres in rats after intramuscular injections of three consecutive doses of 0.6 mg/kg per 28 days. The results revealed that the pharmacokinetic profile of triptorelin produced an initial flare-up in testosterone levels, rapid castration within 5 days after injection, and long-term castration until the next dose.
• Analytical and bioanalytical chemistry.Anal Bioanal Chem.2014 Apr;406(9-10):2457-65. doi: 10.1007/s00216-014-7616-z. Epub 2014 Feb 9.
• Triptorelin, a gonadotropin-releasing hormone agonist, has been used in the treatment of hormone-responsive prostate cancer by inducing testosterone suppression. Research on the relationship between the time courses of triptorelin and testosterone is very important, but accurate quantification of tr
• PMID 24510211

• Leishmaniasis in immunosuppressed individuals.

• van Griensven J1, Carrillo E, López-Vélez R, Lynen L, Moreno J.Author information 1Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.AbstractLeishmaniasis is a vector-born chronic infectious disease caused by a group of protozoan parasites of the genus Leishmania. Whereas most immunocompetent individuals will not develop disease after Leishmania infection, immunosuppression is a well-established risk factor for disease. The most severe form is visceral leishmaniasis (VL), which is typically fatal if untreated. Whereas human immunodeficiency virus (HIV) co-infection (VL-HIV) was initially mainly reported from southern Europe, it is now emerging in other regions, including East Africa, India, and Brazil. VL has also been found in a wide range of non-HIV-related immunosuppressive states, mainly falling under the realm of transplantation medicine, rheumatology, haematology, and oncology. Clinical presentation can be atypical in immunosuppressed individuals, being easily misdiagnosed or mistaken as a flare-up of the underlying disease. The best diagnostic approach is the combination of parasitological and serological or molecular methods. Liposomal amphotericin B is the drug of choice. Treatment failure and relapse rates are particularly high in cases of HIV co-infection, despite initiation of antiretroviral treatment. Primary prophylaxis is not recommended, but secondary prophylaxis is recommended when the patient is immunosuppressed. Cutaneous leishmaniasis can have a number of particular features in individuals with immunosuppression, especially if severe, including parasite dissemination, clinical polymorphism with atypical and often more severe clinical forms, and even visceralization. Mucosal leishmaniasis is more common. Treatment of cutaneous and mucosal leishmaniasis can be challenging, and systemic treatment is more often indicated. With globally increased travel and access to advanced medical care in developing countries, the leishmaniasis burden in immunosuppressed individuals will probably continue to rise, warranting increased awareness and enhanced surveillance systems.
• Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.Clin Microbiol Infect.2014 Apr;20(4):286-99. doi: 10.1111/1469-0691.12556. Epub 2014 Feb 20.
• Leishmaniasis is a vector-born chronic infectious disease caused by a group of protozoan parasites of the genus Leishmania. Whereas most immunocompetent individuals will not develop disease after Leishmania infection, immunosuppression is a well-established risk factor for disease. The most severe f
• PMID 24450618

Japanese Journal

• Successful Use of Adalimumab for Treating Pyoderma Gangrenosum with Ulcerative Colitis under Corticosteroid-tapering Conditions

• Sagami Shintaro,Ueno Yoshitaka,Tanaka Shinji,Nagai Kenta,Hayashi Ryohei,Chayama Kazuaki
• Internal Medicine 54(17), 2167-2172, 2015
• … A 52-year-old woman with ulcerative colitis was admitted to our hospital for an ulcerative colitis flare-up under salazosulfapyridine therapy. …
• NAID 130005097135

• Immune-mediated Neuropathy with Anti-disialosyl IgM Antibodies in Diffuse Large B-cell Lymphoma: A Case Report and Literature Review

• Shihashi Gen,Yagi Takuya,Suzuki Shigeaki,Seki Morinobu,Kohashi Sumiko,Ueda Tomoki,Kameyama Kaori,Kusunoki Susumu,Nakajima Hideaki,Okamoto Shinichiro,Suzuki Norihiro
• Internal Medicine 54(13), 1647-1651, 2015
• … A 36-year-old man with diffuse large B-cell lymphoma presented with polyneuropathy, and the diagnostic work-up revealed the presence of IgM antibodies against gangliosides with disialosyl residues (GD1b, GD3). … He currently remains in complete remission without a flare-up of the polyneuropathy. …
• NAID 130005086462

• 抗結核薬に対する多剤過敏症を合併した結核性髄膜炎の1例

• 荒井 元美
• 臨床神経学 55(2), 123-125, 2015
• 症例は64歳の男性である．微熱と頭痛が続いたが神経系の障害はみられなかった．髄液の単核球増多，ブドウ糖低下，アデノシンデアミナーゼ高値から結核性髄膜炎をうたがってイソニアジド，リファンピシン，ピラジナミド，エタンブトールを使用し症状は軽減した．しかし治療開始20日目から弛張熱が続いた．薬剤熱をうたがいすべての抗結核薬を中止し，3日目に解熱した．薬剤誘発性リンパ球刺激試験でエタンブトール以外の3種類 …
• NAID 130004921317

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• Amazon.co.jp： Flare Up: 音楽

Product DescriptionFirst time on CD for highly collectable jazz classic originally released in 1970. Becket played alongside Charles Mingus in the 1961 film All Night Long & was a long-serving member of Charles MacGregor's Brotherhood Of Breath & Graham Collier's various ou

• flare-upの意味 - 英和辞書 - goo辞書

flare-upとは。意味や和訳。[名]1 ぱっと燃え上がること；（信号の）閃光(せんこう).2 （発作的な）激怒；（騒ぎ・病気などの）突発，再燃. - goo辞書は国語、英和、和英、中国語、百科事典等からまとめて探せる辞書検索サービスです。

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