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1. Overview of atrial fibrillation
2. 新規発症した心房細動のマネージメント management of new onset atrial fibrillation
3. 発作性心房細動 paroxysmal atrial fibrillation
4. 心房細動における心拍数のコントロール：薬理療法 control of ventricular rate in atrial fibrillation pharmacologic therapy
5. 心房細動の疫学および危険因子 epidemiology of and risk factors for atrial fibrillation

English Journal

AFM-Based Single Molecule Techniques: unraveling the Amyloid Pathogenic Species.

Ruggeri FS1, Habchi J, Cerreta A, Dietler G.
Current pharmaceutical design.Curr Pharm Des.2016 May 18. [Epub ahead of print]
BACKGROUND: A wide class of human diseases and neurodegenerative disorders, such as Alzheimer's disease, is due to the failure of a specific peptide or protein to keep its native functional conformational state and to undergo a conformational change into a misfolded state, triggering the formation o
PMID 27189600

The protonation state of histidine 111 regulates the aggregation of the evolutionary most conserved region of the human prion protein.

Fonseca-Ornelas L1, Zweckstetter M1,2,3.
Protein science : a publication of the Protein Society.Protein Sci.2016 May 17. doi: 10.1002/pro.2947. [Epub ahead of print]
In a group of neurodegenerative diseases, collectively termed transmissible spongiform encephalopathies, the prion protein aggregates into β-sheet rich amyloid-like deposits. Because amyloid structure has been connected to different prion strains and cellular toxicity, it is important to obtain ins
PMID 27184108

Evidence for Inhibition of Lysozyme Amyloid Fibrillization by Peptide Fragments from Human Lysozyme: A Combined Spectroscopy, Microscopy, and Docking Study.

Kar RK1, Gazova Z2,3, Bednarikova Z2,4, Mroue KH5, Ghosh A1, Zhang R6, Ulicna K2,7, Siebert HC6, Nifantiev NE8, Bhunia A1.
Biomacromolecules.Biomacromolecules.2016 May 3. [Epub ahead of print]
Degenerative diseases, such as Alzheimer's and prion diseases, as well as type II diabetes, have a pathogenesis associated with protein misfolding, which routes with amyloid formation. Recent strategies for designing small-molecule and polypeptide antiamyloid inhibitors are mainly based on mature fi
PMID 27116396

Asano Akira,Abe Yuki,Takeuchi Ken,Kamihira-Ishijima Miya,Itoh-Watanabe Hikari,Kawamura Izuru,Ramamoorthy Ayyalusamy,Naito Akira
生物物理 53(SUPPLEMENT_1-2), S223, 2013-09-13
NAID 110009819873