フェソテロジン
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/11/14 19:41:55」(JST)
[Wiki en表示]
Fesoterodine
|
|
Systematic (IUPAC) name |
[2-[(1R)-3-(Di(propan-2-yl)amino)-1-phenylpropyl]-4-(hydroxymethyl)phenyl] 2-methylpropanoate
|
Clinical data |
Trade names |
Toviaz |
AHFS/Drugs.com |
monograph |
MedlinePlus |
a609021 |
Licence data |
EMA:Link, US FDA:link |
Pregnancy
category |
- US: C (Risk not ruled out)
|
Legal status |
|
Routes of
administration |
Oral |
Pharmacokinetic data |
Bioavailability |
52% (active metabolite) |
Protein binding |
50% (active metabolite) |
Metabolism |
Hepatic (CYP2D6- and 3A4-mediated) |
Biological half-life |
7–8 hours (active metabolite) |
Excretion |
Renal (70%) and fecal (7%) |
Identifiers |
CAS Registry Number |
286930-03-8 N |
ATC code |
G04BD11 |
PubChem |
CID: 6918558 |
IUPHAR/BPS |
7473 |
DrugBank |
DB06702 Y |
ChemSpider |
5293755 Y |
UNII |
621G617227 Y |
KEGG |
D07226 Y |
ChEMBL |
CHEMBL1201764 N |
Chemical data |
Formula |
C26H37NO3 |
Molecular mass |
411.278 g/mol |
SMILES
-
O=C(Oc1ccc(cc1[C@@H](c2ccccc2)CCN(C(C)C)C(C)C)CO)C(C)C
|
InChI
-
InChI=1S/C26H37NO3/c1-18(2)26(29)30-25-13-12-21(17-28)16-24(25)23(22-10-8-7-9-11-22)14-15-27(19(3)4)20(5)6/h7-13,16,18-20,23,28H,14-15,17H2,1-6H3/t23-/m1/s1 Y
-
Key:DCCSDBARQIPTGU-HSZRJFAPSA-N Y
|
N (what is this?) (verify) |
Fesoterodine (INN, used as the fumarate under the brand name Toviaz) is an antimuscarinic drug developed by Schwarz Pharma AG to treat overactive bladder syndrome (OAB).[1] It was approved by the European Medicines Agency in April 2007,[2] the US Food and Drug Administration on October 31, 2008 [3] and Health Canada on February 9, 2012.[4]
Fesoterodine is a prodrug. It is broken down into its active metabolite, 5-hydroxymethyl tolterodine, by plasma esterases.
Efficacy
Fesoterodine has the advantage of allowing more flexible dosage than other muscarinic antagonists.[5] Its tolerability and side effects are similar to other muscarinic antagonists and as a new drug seems unlikely to make great changes in practices of treatment for overactive bladder.[5]
References
- ^ "Fesoterodine, New Drug Candidate For Treatment For Overactive Bladder – Pfizer To Acquire Exclusive Worldwide Rights". Medical News Today. 17 April 2006.
- ^ "Toviaz: European Public Assessment Report, Revision 3 - Published 02/06/08". European Medicines Agency. 2 June 2008.
- ^ "Pfizer's Toviaz (fesoterodine fumarate) Receives FDA Approval for the Treatment of Overactive Bladder" (Press release). Pfizer Inc. 2008-10-31. Retrieved 2008-11-06.
- ^ Notice of Decision for TOVIAZ
- ^ a b Vella, M.; Cardozo, L. (2011). "Review of fesoterodine". Expert Opinion on Drug Safety 10 (5): 805–808. doi:10.1517/14740338.2011.591377. PMID 21639817.
Urologicals, including antispasmodics (G04B)
|
|
Acidifiers |
- Ammonium chloride
- Calcium chloride
|
|
Urinary antispasmodics
(primarily antimuscarinics) |
- Darifenacin
- Emepronium
- Fesoterodine
- Flavoxate
- Imidafenacin
- Meladrazine
- Mirabegron
- Oxybutynin
- Propiverine
- Solifenacin
- Terodiline
- Tolterodine
- Trospium chloride
|
|
Other urologicals |
- Urea analogues: Acetohydroxamic acid
- Salicylhydroxamic acid
- Other: Collagen
- Dimethyl sulfoxide
- Magnesium hydroxide
- Pentosan polysulfate
- Phenazopyridine
- Phenyl salicylate
- Succinimide
|
|
Index of the urinary system
|
|
Description |
- Anatomy
- Physiology
- Development
- Cells
|
|
Disease |
- Electrolyte and acid-base
- Congenital
- Neoplasms and cancer
- Other
- Symptoms and signs
- Urine tests
- Blood tests
|
|
Treatment |
- Procedures
- Drugs
- Intravenous fluids
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Effect of fesoterodine on urethral closure function in women with stress urinary incontinence assessed by urethral pressure reflectometry.
- Klarskov N1, Darekar A, Scholfield D, Whelan L, Lose G.
- International urogynecology journal.Int Urogynecol J.2014 Jun;25(6):755-60. doi: 10.1007/s00192-013-2269-6. Epub 2013 Nov 21.
- INTRODUCTION AND HYPOTHESIS: The aim was to evaluate, using urethral pressure reflectometry (UPR), the effect of fesoterodine on urethral function in women with stress urinary incontinence (SUI).METHODS: Women aged 18 to 65 years were eligible for this randomised, double-blind, placebo-controlled,
- PMID 24258099
- An observational study of patient satisfaction with fesoterodine in the treatment of overactive bladder: effects of additional educational material.
- Schneider T1, Arumi D, Crook TJ, Sun F, Michel MC.
- International journal of clinical practice.Int J Clin Pract.2014 May 5. doi: 10.1111/ijcp.12450. [Epub ahead of print]
- AIM: To compare the effects of additional educational material on treatment satisfaction of overactive bladder (OAB) patients treated with a muscarinic receptor antagonist.METHODS: In an observational study of OAB patients being treated by their physician with fesoterodine for 4 months (FAKTEN stud
- PMID 24797765
- Cost effectiveness of fesoterodine and tolterodine for the treatment of overactive bladder with urge urinary incontinence in Spain and Finland.
- Angulo JC1, Valpas A, Rejas J, Linden K, Kvasz M, Snedecor SJ.
- Clinical drug investigation.Clin Drug Investig.2014 May;34(5):297-307. doi: 10.1007/s40261-014-0178-1.
- BACKGROUND: Overactive bladder is a prevalent condition worldwide that is associated with a considerable burden, both on the patient and on society.OBJECTIVE: Our objective was to assess the economic value of fesoterodine compared with tolterodine extended release (ER) for the treatment of overactiv
- PMID 24567280
Japanese Journal
- フェソテロジンフマル酸塩(トビエース<sup>®</sup>錠4 mg・8 mg)の薬理学的特徴および臨床試験成績
- 臨床 新薬レビュー フェソテロジンフマル酸塩 Fesoterodine Fumarate トビエース錠 ファイザー株式会社
Related Links
- 対象疾患 過活動膀胱 治験薬の名称 fesoterodine 治験薬の一般名 Fesoterodine humarate 目的・内容 過活動膀胱(OAB)の患者さんに「2つの異なった量の治験薬」ま たは「有効成分を含まない治験薬(プラセボといいます)」のいず
- Fesoterodine is a prescription medication used to treat symptoms of overactive bladder in adults. Fesoterodine belongs... ... Fesoterodine may cause allergic reactions that may be serious. Symptoms of a serious allergic reaction ...
- Fesoterodine reduces spasms of the bladder muscles. Fesoterodine is used to treat overactive bladder with symptoms of urinary frequency, urgency, and incontinence. Fesoterodine may also be used for purposes not listed in this ...
Related Pictures
★リンクテーブル★
[★]
- 英
- fesoterodine
- 商
- トビエース