発酵性の、発酵の

関: ferment、fermentable、fermentation、fermented

WordNet

work up into agitation or excitement; "Islam is fermenting Africa"
a substance capable of bringing about fermentation
cause to undergo fermentation; "We ferment the grapes for a very long time to achieve high alcohol content"; "The vintner worked the wine in big oak vats" (同)work
be in an agitated or excited state; "The Middle East is fermenting"; "Her mind ferments"
capable of being fermented

PrepTutorEJDIC

発酵[作用] / 動揺,騒ぎ
〈C〉発酵体(酷母,酷素などの発酵を起こさせるものの総称) / 〈U〉発酵 / 〈U〉〈C〉(政治上の)動揺,大騒ぎ / …‘を'発酵させる / …‘を'大騒ぎさせる / 発酵する / 大騒ぎする

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/01/19 23:41:06」(JST)

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Fermentation in progress: Bubbles of CO₂ form a froth on top of the fermentation mixture.

Overview of ethanol fermentation. One glucose molecule breaks down into two pyruvate molecules (1). The energy from this exothermic reaction is used to bind inorganic phosphates to ATP and convert NAD+ to NADH. The two pyruvates are then broken down into two acetaldehyde molecules and give off two CO2 molecules as a waste product (2). The acetaldehyde is then reduced into ethanol using the energy and hydrogen from NADH; in this process the NADH is oxidized into NAD+ so that the cycle may repeat (3).

Fermentation is a metabolic process that converts sugar to acids, gases, or alcohol. It occurs in yeast and bacteria, and also in oxygen-starved muscle cells, as in the case of lactic acid fermentation. Fermentation is also used more broadly to refer to the bulk growth of microorganisms on a growth medium, often with the goal of producing a specific chemical product. French microbiologist Louis Pasteur is often remembered for his insights into fermentation and its microbial causes. The science of fermentation is known as zymology.

Fermentation takes place when the electron transport chain is unusable (often due to lack of a final electron receptor, such as oxygen). In this case it becomes the cell's primary means of ATP (energy) production.^[1] It turns NADH and pyruvate produced in glycolysis into NAD⁺ and an organic molecule (which varies depending on the type of fermentation; see examples below). In the presence of O₂, NADH and pyruvate are used to generate ATP in respiration. This is called oxidative phosphorylation, and it generates much more ATP than glycolysis alone. For that reason, cells generally benefit from avoiding fermentation when oxygen is available, the exception being obligate anaerobes which cannot tolerate oxygen.

The first step, glycolysis, is common to all fermentation pathways:

C₆H₁₂O₆ + 2 NAD⁺ + 2 ADP + 2 P_i → 2 CH₃COCOO⁻ + 2 NADH + 2 ATP + 2 H₂O + 2H⁺

Pyruvate is CH₃COCOO⁻. P_i is inorganic phosphate. Two ADP molecules and two P_i are converted to two ATP and two water molecules via substrate-level phosphorylation. Two molecules of NAD⁺ are also reduced to NADH.^[2]

In oxidative phosphorylation the energy for ATP formation is derived from an electrochemical proton gradient generated across the inner mitochondrial membrane (or, in the case of bacteria, the plasma membrane) via the electron transport chain. Glycolysis has substrate-level phosphorylation (ATP generated directly at the point of reaction).

Humans have used fermentation to produce drinks and beverages since the Neolithic age. For example, fermentation is used for preservation in a process that produces lactic acid as found in such sour foods as pickled cucumbers, kimchi and yogurt (see fermentation in food processing), as well as for producing alcoholic beverages such as wine (see fermentation in winemaking) and beer. Fermentation can even occur within the stomachs of animals, such as humans.

Definitions

To many people, fermentation simply means the production of alcohol: grains and fruits are fermented to produce beer and wine. If a food soured, one might say it was 'off' or fermented. Here are some definitions of fermentation. They range from informal, general usage to more scientific definitions.^[3]

Preservation methods for food via microorganisms (general use).
Any process that produces alcoholic beverages or acidic dairy products (general use).
Any large-scale microbial process occurring with or without air (common definition used in industry).
Any energy-releasing metabolic process that takes place only under anaerobic conditions (becoming more scientific).
Any metabolic process that releases energy from a sugar or other organic molecules, does not require oxygen or an electron transport system, and uses an organic molecule as the final electron acceptor (most scientific).

Examples

Fermentation does not necessarily have to be carried out in an anaerobic environment. For example, even in the presence of abundant oxygen, yeast cells greatly prefer fermentation to aerobic respiration, as long as sugars are readily available for consumption (a phenomenon known as the Crabtree effect).^[4] The antibiotic activity of hops also inhibits aerobic metabolism in yeast^{[citation needed]}.

Fermentation reacts NADH with an endogenous, organic electron acceptor.^[1] Usually this is pyruvate formed from the sugar during the glycolysis step. During fermentation, pyruvate is metabolized to various compounds through several processes:

ethanol fermentation, aka alcoholic fermentation, is the production of ethanol and carbon dioxide
lactic acid fermentation refers to two means of producing lactic acid:

homolactic fermentation is the production of lactic acid exclusively
heterolactic fermentation is the production of lactic acid as well as other acids and alcohols.

Sugars are the most common substrate of fermentation, and typical examples of fermentation products are ethanol, lactic acid, carbon dioxide, and hydrogen gas (H₂). However, more exotic compounds can be produced by fermentation, such as butyric acid and acetone. Yeast carries out fermentation in the production of ethanol in beers, wines, and other alcoholic drinks, along with the production of large quantities of carbon dioxide. Fermentation occurs in mammalian muscle during periods of intense exercise where oxygen supply becomes limited, resulting in the creation of lactic acid.^[5]

Chemistry

Comparison of aerobic respiration and most known fermentation types in eucaryotic cell.^[6] Numbers in circles indicate counts of carbon atoms in molecules, C6 is glucose C₆H₁₂O₆, C1 carbon dioxide CO₂. Mitochondrial outer membrane is omitted.

Fermentation products contain chemical energy (they are not fully oxidized), but are considered waste products, since they cannot be metabolized further without the use of oxygen.

Ethanol fermentation

The chemical equation below shows the alcoholic fermentation of glucose, whose chemical formula is C₆H₁₂O₆.^[7] One glucose molecule is converted into two ethanol molecules and two carbon dioxide molecules:

C₆H₁₂O₆ → 2 C₂H₅OH + 2 CO₂

C₂H₅OH is the chemical formula for ethanol.

Before fermentation takes place, one glucose molecule is broken down into two pyruvate molecules. This is known as glycolysis.^[7]^[8]

Lactic acid fermentation

Homolactic fermentation (producing only lactic acid) is the simplest type of fermentation. The pyruvate from glycolysis^[9] undergoes a simple redox reaction, forming lactic acid.^[2]^[10] It is unique because it is one of the only respiration processes to not produce a gas as a byproduct. Overall, one molecule of glucose (or any six-carbon sugar) is converted to two molecules of lactic acid: C₆H₁₂O₆ → 2 CH₃CHOHCOOH
It occurs in the muscles of animals when they need energy faster than the blood can supply oxygen. It also occurs in some kinds of bacteria (such as lactobacilli) and some fungi. It is this type of bacteria that converts lactose into lactic acid in yogurt, giving it its sour taste. These lactic acid bacteria can carry out either homolactic fermentation, where the end-product is mostly lactic acid, or

Heterolactic fermentation, where some lactate is further metabolized and results in ethanol and carbon dioxide^[2] (via the phosphoketolase pathway), acetate, or other metabolic products, e.g.: C₆H₁₂O₆ → CH₃CHOHCOOH + C₂H₅OH + CO₂
If lactose is fermented (as in yogurts and cheeses), it is first converted into glucose and galactose (both six-carbon sugars with the same atomic formula): C₁₂H₂₂O₁₁ + H₂O → 2 C₆H₁₂O₆
Heterolactic fermentation is in a sense intermediate between lactic acid fermentation, and other types, e.g. alcoholic fermentation (see below). The reasons to go further and convert lactic acid into anything else are:

The acidity of lactic acid impedes biological processes; this can be beneficial to the fermenting organism as it drives out competitors that are unadapted to the acidity; as a result, the food will have a longer shelf life (part of the reason foods are purposely fermented in the first place); however, beyond a certain point, the acidity starts affecting the organism that produces it.
The high concentration of lactic acid (the final product of fermentation) drives the equilibrium backwards (Le Chatelier's principle), decreasing the rate at which fermentation can occur, and slowing down growth.
Ethanol, into which lactic acid can be easily converted, is volatile and will readily escape, allowing the reaction to proceed easily. CO₂ is also produced, but it is only weakly acidic, and even more volatile than ethanol.
Acetic acid (another conversion product) is acidic, and not as volatile as ethanol; however, in the presence of limited oxygen, its creation from lactic acid releases additional energy. It is a lighter molecule than lactic acid, that forms fewer hydrogen bonds with its surroundings (due to having fewer groups that can form such bonds), thus is more volatile and will also allow the reaction to move forward more quickly.
If propionic acid, butyric acid, and longer monocarboxylic acids are produced (see mixed acid fermentation), the amount of acidity produced per glucose consumed will decrease, as with ethanol, allowing faster growth.

Aerobic respiration

In aerobic respiration, the pyruvate produced by glycolysis is oxidized completely, generating additional ATP and NADH in the citric acid cycle and by oxidative phosphorylation. However, this can occur only in the presence of oxygen. Oxygen is toxic to organisms that are obligate anaerobes, and is not required by facultative anaerobic organisms. In the absence of oxygen, one of the fermentation pathways occurs in order to regenerate NAD⁺; lactic acid fermentation is one of these pathways.^[2]

Hydrogen gas production in fermentation

Hydrogen gas is produced in many types of fermentation (mixed acid fermentation, butyric acid fermentation, caproate fermentation, butanol fermentation, glyoxylate fermentation), as a way to regenerate NAD⁺ from NADH. Electrons are transferred to ferredoxin, which in turn is oxidized by hydrogenase, producing H₂.^[7] Hydrogen gas is a substrate for methanogens and sulfate reducers, which keep the concentration of hydrogen low and favor the production of such an energy-rich compound,^[11] but hydrogen gas at a fairly high concentration can nevertheless be formed, as in flatus.

As an example of mixed acid fermentation, bacteria such as Clostridium pasteurianum ferment glucose producing butyrate, acetate, carbon dioxide and hydrogen gas:^[12] The reaction leading to acetate is:

C₆H₁₂O₆ + 4 H₂O → 2 CH₃COO⁻ + 2 HCO₃⁻ + 4 H⁺ + 4 H₂

Glucose could theoretically be converted into just CO₂ and H₂, but the global reaction releases little energy.

Methane gas production in fermentation

Acetic acid can also undergo a dismutation reaction to produce methane and carbon dioxide:^[13]^[14]

CH₃COO⁻ + H⁺ → CH₄ + CO₂ ΔG° = -36 kJ/reaction

This disproportionation reaction is catalysed by methanogen archaea in their fermentative metabolism. One electron is transferred from the carbonyl function (e⁻ donor) of the carboxylic group to the methyl group (e⁻ acceptor) of acetic acid to respectively produce CO₂ and methane gas.

History of human use

The use of fermentation, particularly for beverages, has existed since the Neolithic and has been documented dating from 7000–6600 BCE in Jiahu, China,^[15] 5000 BCE in India, Ayurveda mentions many Medicated Wines, 6000 BCE in Georgia,^[16] 3150 BCE in ancient Egypt,^[17] 3000 BCE in Babylon,^[18] 2000 BCE in pre-Hispanic Mexico,^[18] and 1500 BC in Sudan.^[19] Fermented foods have a religious significance in Judaism and Christianity. The Baltic god Rugutis was worshiped as the agent of fermentation.^[20]^[21]

The first solid evidence of the living nature of yeast appeared between 1837 and 1838 when three publications appeared by C. Cagniard de la Tour, T. Swann, and F. Kuetzing, each of whom independently concluded as a result of microscopic investigations that yeast is a living organism that reproduces by budding. It is perhaps because wine, beer, and bread were each basic foods in Europe that most of the early studies on fermentation were done on yeasts, with which they were made. Soon, bacteria were also discovered; the term was first used in English in the late 1840s, but it did not come into general use until the 1870s, and then largely in connection with the new germ theory of disease.^[22]

Louis Pasteur in his laboratory

Louis Pasteur (1822–1895), during the 1850s and 1860s, showed that fermentation is initiated by living organisms in a series of investigations.^[10] In 1857, Pasteur showed that lactic acid fermentation is caused by living organisms.^[23] In 1860, he demonstrated that bacteria cause souring in milk, a process formerly thought to be merely a chemical change, and his work in identifying the role of microorganisms in food spoilage led to the process of pasteurization.^[24] In 1877, working to improve the French brewing industry, Pasteur published his famous paper on fermentation, "Etudes sur la Bière", which was translated into English in 1879 as "Studies on fermentation".^[25] He defined fermentation (incorrectly) as "Life without air",^[26] but correctly showed that specific types of microorganisms cause specific types of fermentations and specific end-products.

Although showing fermentation to be the result of the action of living microorganisms was a breakthrough, it did not explain the basic nature of the fermentation process, or prove that it is caused by the microorganisms that appear to be always present. Many scientists, including Pasteur, had unsuccessfully attempted to extract the fermentation enzyme from yeast.^[26] Success came in 1897 when the German chemist Eduard Buechner ground up yeast, extracted a juice from them, then found to his amazement that this "dead" liquid would ferment a sugar solution, forming carbon dioxide and alcohol much like living yeasts.^[27] Buechner's results are considered to mark the birth of biochemistry. The "unorganized ferments" behaved just like the organized ones. From that time on, the term enzyme came to be applied to all ferments. It was then understood that fermentation is caused by enzymes that are produced by microorganisms.^[28] In 1907, Buechner won the Nobel Prize in chemistry for his work.^[29]

Advances in microbiology and fermentation technology have continued steadily up until the present. For example, in the late 1970s, it was discovered that microorganisms could be mutated with physical and chemical treatments to be higher-yielding, faster-growing, tolerant of less oxygen, and able to use a more concentrated medium.^[30] Strain selection and hybridization developed as well, affecting most modern food fermentations. Other approaches to advancing the fermentation industry has been done by companies such as BioTork, a biotechnology company that naturally evolves microorganisms to improve fermentation processes. This approach differs from the more popular genetic modification, which has become the current industry standard.

Etymology

The word "ferment" is derived from the Latin verb fervere, which means to boil. It is thought to have been first used in the late 14th century in alchemy, but only in a broad sense. It was not used in the modern scientific sense until around 1600.

References

^ ^a ^b Klein, Donald W.; Lansing M.; Harley, John (2006). Microbiology (6th ed.). New York: McGraw-Hill. ISBN 978-0-07-255678-0.
^ ^a ^b ^c ^d AP Biology. Anestis, Mark. 2nd Edition. McGraw-Hill Professional. 2006. ISBN 978-0-07-147630-0. p. 61
^ Tortora, Gerard J.; Funke, Berdell R.; Case, Christine L. (2010). "5". Microbiology An Introduction (10 ed.). San Francisco, CA 94111, USA: Pearson Benjamin Cummings. p. 135. ISBN 978-0-321-58202-7.
^ Dickinson, J. R. (1999). "Carbon metabolism". In J. R. Dickinson; M. Schweizer. The metabolism and molecular physiology of Saccharomyces cerevisiae. Philadelphia, PA: Taylor & Francis. ISBN 978-0-7484-0731-6.
^ Voet, Donald; Voet, Judith G. (1995). Biochemistry (2nd ed.). New York, NY: John Wiley & Sons. ISBN 978-0-471-58651-7.
^ Stryer, Lubert (1995). Biochemistry (fourth ed.). New York - Basingstoke: W. H. Freeman and Company. ISBN 978-0716720096.
^ ^a ^b ^c Life, the science of biology. Purves, William Kirkwood. Sadava, David. Orians, Gordon H. 7th Edition. Macmillan Publishers. 2004. ISBN 978-0-7167-9856-9. pp. 139–140
^ Stryer, Lubert (1975). Biochemistry. W. H. Freeman and Company. ISBN 0-7167-0174-X.
^ Introductory Botany: plants, people, and the Environment. Berg, Linda R. Cengage Learning, 2007. ISBN 978-0-534-46669-5. p. 86
^ ^a ^b A dictionary of applied chemistry, Volume 3. Thorpe, Sir Thomas Edward. Longmans, Green and Co., 1922. p.159
^ Madigan, Michael T.; Martinko, John M.; Parker, Jack (1996). Brock biology of microorganisms (8th ed.). Prentice Hall. ISBN 978-0-13-520875-5.
^ Thauer, R.K.; Jungermann, K.; Decker, K. (1977). "Energy conservation in chemotrophic anaerobic bacteria". Bacteriological Reviews. 41 (1): 100–80. ISSN 0005-3678. PMC 413997. PMID 860983.
^ Ferry, J.G. (1992). "Methane from acetate". Journal of Bacteriology. 174 (17): 5489–5495. PMC 206491. PMID 1512186. Retrieved 2011-11-05.
^ Vogels, G.D.; Keltjens J.T.; Van Der Drift C. (1988). "Biochemistry of methane production". In Zehnder A.J.B. Biology of anaerobic microorganisms. New York: Wiley. pp. 707–770.
^ McGovern, P. E.; Zhang, J.; Tang, J.; Zhang, Z.; Hall, G. R.; Moreau, R. A.; Nunez, A.; Butrym, E. D.; Richards, M. P.; Wang, C. -S.; Cheng, G.; Zhao, Z.; Wang, C. (2004). "Fermented beverages of pre- and proto-historic China". Proceedings of the National Academy of Sciences. 101 (51): 17593–17598. doi:10.1073/pnas.0407921102. PMC 539767. PMID 15590771.
^ Vouillamoz, J. F.; McGovern, P. E.; Ergul, A.; Söylemezoğlu, G. K.; Tevzadze, G.; Meredith, C. P.; Grando, M. S. (2006). "Genetic characterization and relationships of traditional grape cultivars from Transcaucasia and Anatolia". Plant Genetic Resources: characterization and utilization. 4 (2): 144. doi:10.1079/PGR2006114.
^ Cavalieri, D; McGovern P.E.; Hartl D.L.; Mortimer R.; Polsinelli M. (2003). "Evidence for S. cerevisiae fermentation in ancient wine" (PDF). Journal of Molecular Evolution. 57 Suppl 1: S226–32. doi:10.1007/s00239-003-0031-2. PMID 15008419. 15008419. Archived from the original (PDF) on December 9, 2006. Retrieved 2007-01-28.
^ ^a ^b "Fermented fruits and vegetables. A global perspective". FAO Agricultural Services Bulletins - 134. Archived from the original on January 19, 2007. Retrieved 2007-01-28.
^ Dirar, H., (1993), The Indigenous Fermented Foods of the Sudan: A Study in African Food and Nutrition, CAB International, UK
^ "Gintaras Beresneviius. M. Strijkovskio Kronikos" lietuvi diev sraas". spauda.lt.
^ Rūgutis. Mitologijos enciklopedija, 2 tomas. Vilnius. Vaga. 1999. 293 p.
^ A brief history of fermentation, East and West. Soyinfocenter.com. Retrieved on 2011-01-04.
^ Accomplishments of Louis Pasteur. Fjcollazo.com (2005-12-30). Retrieved on 2011-01-04.
^ HowStuffWorks "Louis Pasteur". Science.howstuffworks.com (2009-07-01). Retrieved on 2011-01-04.
^ Louis Pasteur (1879) Studies on fermentation: The diseases of beer, their causes, and the means of preventing them. Macmillan Publishers.
^ ^a ^b Modern History Sourcebook: Louis Pasteur (1822–1895): Physiological theory of fermentation, 1879. Translated by F. Faulkner, D.C. Robb.
^ New beer in an old bottle: Eduard Buchner and the Growth of Biochemical Knowledge. Cornish-Bowden, Athel. Universitat de Valencia. 1997. ISBN 978-84-370-3328-0. p. 25.
^ The enigma of ferment: from the philosopher's stone to the first biochemical Nobel prize. Lagerkvist, Ulf. World Scientific Publishers. 2005. ISBN 978-981-256-421-4. p. 7.
^ A treasury of world science, Volume 1962, Part 1. Runes, Dagobert David. Philosophical Library Publishers. 1962. p. 109.
^ Wang, H. L.; Swain, E. W.; Hesseltine, C. W. (1980). "Phytase of molds used in oriental food fermentation". Journal of Food Science. 45 (5): 1262. doi:10.1111/j.1365-2621.1980.tb06534.x.

External links

Works of Louis Pasteur Pasteur Brewing.
The chemical logic behind fermentation and respiration

UpToDate Contents

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1. ステノトロフォモナス・マルトフィリア stenotrophomonas maltophilia

English Journal

20S proteasome activity is modified via S-glutathionylation based on intracellular redox status of the yeast Saccharomyces cerevisiae: Implications for the degradation of oxidized proteins.

Demasi M1, Hand A2, Ohara E2, Oliveira CL3, Bicev RN3, Bertoncini CA4, Netto LE5.
Archives of biochemistry and biophysics.Arch Biochem Biophys.2014 Sep 1;557:65-71. doi: 10.1016/j.abb.2014.05.002. Epub 2014 May 9.
Protein S-glutathionylation is a post-translational modification that controls many cellular pathways. Recently, we demonstrated that the α5-subunit of the 20S proteasome is S-glutathionylated in yeast cells grown to the stationary phase in rich medium containing glucose, stimulating 20S core gate
PMID 24813691

Comparing lactate and glycerol as a single-electron donor for sulfate reduction in fluidized bed reactors.

Bertolino SM1, Melgaço LA, Sá RG, Leão VA.
Biodegradation.Biodegradation.2014 Sep;25(5):719-33. doi: 10.1007/s10532-014-9694-1. Epub 2014 Jun 15.
Among the greatest challenges to the full implementation of biological sulfate reduction are the cost and availability of the electron source. With the development of the biofuel industry, new organic substrates have become available. Therefore, this work sought to compare the performance of a sulfi
PMID 24929339

Assessment of microbial communities associated with fermentative-methanogenic biodegradation of aromatic hydrocarbons in groundwater contaminated with a biodiesel blend (B20).

Ramos DT1, da Silva ML, Nossa CW, Alvarez PJ, Corseuil HX.
Biodegradation.Biodegradation.2014 Sep;25(5):681-91. doi: 10.1007/s10532-014-9691-4. Epub 2014 Apr 19.
A controlled field experiment was conducted to assess the potential for fermentative-methanogenic biostimulation (by ammonium-acetate injection) to enhance biodegradation of benzene, toluene, ethylbenzene and xylenes (BTEX) as well as polycyclic aromatic hydrocarbons (PAHs) in groundwater contaminat
PMID 24748449

Japanese Journal

Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli.

Nature communications 7, 2016-02-05
NAID 120005702806

トウモロコシ子実主体サイレージ（HMSCおよびCCM）の飼料成分組成，発酵品質および栄養価

日本畜産学会報 87(2), 125-131, 2016
NAID 130005157880

多発性骨髄腫に対するbortezomib治療中に発症したAchromobacter xylosoxidansによる蜂窩織炎

臨床血液 57(2), 175-179, 2016
NAID 130005132700

★リンクテーブル★

リンク元	「ferment」「発酵性」「fermentable」「fermented」

「ferment」

　　[★]

vt.

発酵させる。(血潮など)沸き立たせる、たぎる、刺激する、かき立てる

関: fermentation、fermentative

「発酵性」

　　[★]

英: fermentative、fermentable、fermented
関: 発酵

「fermentable」

　　[★]

発酵性の

関: fermentative、fermented

「fermented」

　　[★]

発酵性の

関: fermentable、fermentative

[Prescott_Microbiology-1] Klein, Donald W.; Lansing M.; Harley, John (2006). Microbiology (6th ed.). New York: McGraw-Hill. ISBN 978-0-07-255678-0.

[AP_Biology._Anestis_2006._P._61-2] AP Biology. Anestis, Mark. 2nd Edition. McGraw-Hill Professional. 2006. ISBN 978-0-07-147630-0. p. 61

[3] Tortora, Gerard J.; Funke, Berdell R.; Case, Christine L. (2010). "5". Microbiology An Introduction (10 ed.). San Francisco, CA 94111, USA: Pearson Benjamin Cummings. p. 135. ISBN 978-0-321-58202-7.

[4] Dickinson, J. R. (1999). "Carbon metabolism". In J. R. Dickinson; M. Schweizer. The metabolism and molecular physiology of Saccharomyces cerevisiae. Philadelphia, PA: Taylor & Francis. ISBN 978-0-7484-0731-6.

[Voet_and_Voet.2C_Biochemistry-5] Voet, Donald; Voet, Judith G. (1995). Biochemistry (2nd ed.). New York, NY: John Wiley & Sons. ISBN 978-0-471-58651-7.

[6] Stryer, Lubert (1995). Biochemistry (fourth ed.). New York - Basingstoke: W. H. Freeman and Company. ISBN 978-0716720096.

[Life_2004._pp._139-140-7] Life, the science of biology. Purves, William Kirkwood. Sadava, David. Orians, Gordon H. 7th Edition. Macmillan Publishers. 2004. ISBN 978-0-7167-9856-9. pp. 139–140

[stryer-8] Stryer, Lubert (1975). Biochemistry. W. H. Freeman and Company. ISBN 0-7167-0174-X.

[Introductory_Botany_2007._p._86-9] Introductory Botany: plants, people, and the Environment. Berg, Linda R. Cengage Learning, 2007. ISBN 978-0-534-46669-5. p. 86

[Volume_3._Thorpe_1922._p.159-10] A dictionary of applied chemistry, Volume 3. Thorpe, Sir Thomas Edward. Longmans, Green and Co., 1922. p.159

[11] Madigan, Michael T.; Martinko, John M.; Parker, Jack (1996). Brock biology of microorganisms (8th ed.). Prentice Hall. ISBN 978-0-13-520875-5.

[12] Thauer, R.K.; Jungermann, K.; Decker, K. (1977). "Energy conservation in chemotrophic anaerobic bacteria". Bacteriological Reviews. 41 (1): 100–80. ISSN 0005-3678. PMC 413997. PMID 860983.

[13] Ferry, J.G. (1992). "Methane from acetate". Journal of Bacteriology. 174 (17): 5489–5495. PMC 206491. PMID 1512186. Retrieved 2011-11-05.

[14] Vogels, G.D.; Keltjens J.T.; Van Der Drift C. (1988). "Biochemistry of methane production". In Zehnder A.J.B. Biology of anaerobic microorganisms. New York: Wiley. pp. 707–770.

[mcgovern-15] McGovern, P. E.; Zhang, J.; Tang, J.; Zhang, Z.; Hall, G. R.; Moreau, R. A.; Nunez, A.; Butrym, E. D.; Richards, M. P.; Wang, C. -S.; Cheng, G.; Zhao, Z.; Wang, C. (2004). "Fermented beverages of pre- and proto-historic China". Proceedings of the National Academy of Sciences. 101 (51): 17593–17598. doi:10.1073/pnas.0407921102. PMC 539767. PMID 15590771.

[mcgoverng-16] Vouillamoz, J. F.; McGovern, P. E.; Ergul, A.; Söylemezoğlu, G. K.; Tevzadze, G.; Meredith, C. P.; Grando, M. S. (2006). "Genetic characterization and relationships of traditional grape cultivars from Transcaucasia and Anatolia". Plant Genetic Resources: characterization and utilization. 4 (2): 144. doi:10.1079/PGR2006114.

[Cavalieri-17] Cavalieri, D; McGovern P.E.; Hartl D.L.; Mortimer R.; Polsinelli M. (2003). "Evidence for S. cerevisiae fermentation in ancient wine" (PDF). Journal of Molecular Evolution. 57 Suppl 1: S226–32. doi:10.1007/s00239-003-0031-2. PMID 15008419. 15008419. Archived from the original (PDF) on December 9, 2006. Retrieved 2007-01-28.

[FAO-18] "Fermented fruits and vegetables. A global perspective". FAO Agricultural Services Bulletins - 134. Archived from the original on January 19, 2007. Retrieved 2007-01-28.

[Dirar-19] Dirar, H., (1993), The Indigenous Fermented Foods of the Sudan: A Study in African Food and Nutrition, CAB International, UK

[20] "Gintaras Beresneviius. M. Strijkovskio Kronikos" lietuvi diev sraas". spauda.lt.

[21] Rūgutis. Mitologijos enciklopedija, 2 tomas. Vilnius. Vaga. 1999. 293 p.

[22] A brief history of fermentation, East and West. Soyinfocenter.com. Retrieved on 2011-01-04.

[23] Accomplishments of Louis Pasteur. Fjcollazo.com (2005-12-30). Retrieved on 2011-01-04.

[24] HowStuffWorks "Louis Pasteur". Science.howstuffworks.com (2009-07-01). Retrieved on 2011-01-04.

[25] Louis Pasteur (1879) Studies on fermentation: The diseases of beer, their causes, and the means of preventing them. Macmillan Publishers.

[Modern_History_Sourcebook_1895-26] Modern History Sourcebook: Louis Pasteur (1822–1895): Physiological theory of fermentation, 1879. Translated by F. Faulkner, D.C. Robb.

[27] New beer in an old bottle: Eduard Buchner and the Growth of Biochemical Knowledge. Cornish-Bowden, Athel. Universitat de Valencia. 1997. ISBN 978-84-370-3328-0. p. 25.

[28] The enigma of ferment: from the philosopher's stone to the first biochemical Nobel prize. Lagerkvist, Ulf. World Scientific Publishers. 2005. ISBN 978-981-256-421-4. p. 7.

[29] A treasury of world science, Volume 1962, Part 1. Runes, Dagobert David. Philosophical Library Publishers. 1962. p. 109.

[30] Wang, H. L.; Swain, E. W.; Hesseltine, C. W. (1980). "Phytase of molds used in oriental food fermentation". Journal of Food Science. 45 (5): 1262. doi:10.1111/j.1365-2621.1980.tb06534.x.

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fermentative