WordNet

relating to or having the characteristics of a family; "children of the same familial background"; "familial aggregation"
occurring among members of a family usually by heredity; "an inherited disease"; "familial traits"; "genetically transmitted features" (同)genetic, hereditary, inherited, transmitted, transmissible
malignant ocular tumor of retinal cells; usually occurs before the third year of life; composed of primitive small round retinal cells

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1. 網膜芽細胞腫：臨床症状、評価、診断 retinoblastoma clinical presentation evaluation and diagnosis
2. 網膜芽細胞腫：治療と転帰 retinoblastoma treatment and outcome
3. 白色瞳孔を有する小児に対するアプローチ approach to the child with leukocoria
4. 軟部および骨肉腫の病原因子 pathogenetic factors in soft tissue and bone sarcomas
5. 松果体部腫瘍 pineal gland masses

The activation of type 1 corticotropin releasing factor receptor (CRF-R1) inhibits proliferation and promotes differentiation of neuroblastoma cells in vitro via p27(Kip1) protein up-regulation and c-Myc mRNA down-regulation.

Pozzoli G1, De Simone ML2, Cantalupo E2, Cenciarelli C3, Lisi L2, Boninsegna A4, Dello Russo C2, Sgambato A4, Navarra P2.
Molecular and cellular endocrinology.Mol Cell Endocrinol.2015 Sep 5;412:205-15. doi: 10.1016/j.mce.2015.05.004. Epub 2015 May 7.
Our group has previously shown that corticotropin releasing factor (CRF) inhibits proliferation of human endocrine-related cancer cell lines via the activation of CRF type-1 receptors (CRF-R1). Tumors originating from the nervous system also express CRF receptors but their role on neoplastic cell pr
PMID 25960164

Dukelow T1, Kishan D, Khasraw M, Murphy CG.
Anti-cancer drugs.Anticancer Drugs.2015 Sep;26(8):797-806. doi: 10.1097/CAD.0000000000000249.
Deregulation of the cyclin-dependent kinase (CDK) 4/6-retinoblastoma (RB) axis can occur through a number of mechanisms and contributes towards the unrestrained growth witnessed in a variety of cancers including breast cancers. Recent years have seen the development of selective CDK4/6 inhibitors, w
PMID 26053278

Retinoblastoma Protein Knockdown Favors Oxidative Metabolism and Glucose and Fatty Acid Disposal in Muscle Cells.

Petrov PD1, Ribot J1, López-Mejía IC2, Fajas L2, Palou A1, Bonet ML1.
Journal of cellular physiology.J Cell Physiol.2015 Aug 4. doi: 10.1002/jcp.25121. [Epub ahead of print]
Deficiency in the retinoblastoma protein (Rb) favors leanness and a healthy metabolic profile in mice largely attributed to activation of oxidative metabolism in white and brown adipose tissues. Less is known about Rb modulation of skeletal muscle metabolism. This was studied here by transiently kno
PMID 26241807

Inducible and Transmissible Genetic Events and Pediatric Tumors of the Nervous System

RICE Jerry M.
Journal of radiation research 47(Supplement_B), B1-B11, 2006-09
… Tumors of the nervous system most often occur in both children and adults as sporadic events with no family history of the disease, but they are also among the clinical manifestations of a significant number of familial cancer syndromes, including familial retinoblastoma, neurofibromatosis 1 and 2, tuberous sclerosis, and Cowden, Turcot, Li-Fraumeni and nevoid basal cell carcinoma (Gorlin) syndromes. …
NAID 110004810212