ファレカルシトリオール
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/20 23:34:51」(JST)
[Wiki en表示]
Falecalcitriol
|
Systematic (IUPAC) name |
(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-Methyl-1-[(2R)-7,7,7-trifluoro-6-hydroxy-6-(trifluoromethyl)heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
|
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Legal status |
|
Routes of
administration |
Oral |
Identifiers |
CAS Registry Number |
83805-11-2 Y |
ATC code |
None |
PubChem |
CID: 5282190 |
IUPHAR/BPS |
2781 |
ChemSpider |
4445383 N |
UNII |
G70A8514T8 Y |
KEGG |
D01662 Y |
Chemical data |
Formula |
C27H38F6O3 |
Molecular mass |
524.57 g/mol |
SMILES
-
C[C@H](CCCC(C(F)(F)F)(C(F)(F)F)O)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](C[C@@H](C3=C)O)O)C
|
InChI
-
InChI=1S/C27H38F6O3/c1-16(6-4-13-25(36,26(28,29)30)27(31,32)33)21-10-11-22-18(7-5-12-24(21,22)3)8-9-19-14-20(34)15-23(35)17(19)2/h8-9,16,20-23,34-36H,2,4-7,10-15H2,1,3H3/b18-8+,19-9-/t16-,20-,21-,22+,23+,24-/m1/s1 N
-
Key:XPYGGHVSFMUHLH-UUSULHAXSA-N N
|
N (what is this?) (verify) |
Falecalcitriol (INN) is an analog of calcitriol. It has a higher potency both in vivo and in vitro systems, and longer duration of action in vivo.[1]
References
- ^ Okamoto S, Ejima E, Kiriyama T et al. (1991). "Mechanism of action of newly developed vitamin D analogue". Contrib Nephrol 91: 146–8. PMID 1666031.
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Vitamin D compounds for people with chronic kidney disease not requiring dialysis.
- Palmer SC1, McGregor DO, Craig JC, Elder G, Macaskill P, Strippoli GF.
- The Cochrane database of systematic reviews.Cochrane Database Syst Rev.2009 Oct 7;(4):CD008175. doi: 10.1002/14651858.CD008175.
- BACKGROUND: Vitamin D compounds are used to suppress elevated serum parathyroid hormone (PTH) in people with chronic kidney disease (CKD).OBJECTIVES: To assess the efficacy of vitamin D therapy on biochemical, bone, cardiovascular, and mortality outcomes in people with CKD and not requiring dialysis
- PMID 19821446
- Comparison of oral falecalcitriol and intravenous calcitriol in hemodialysis patients with secondary hyperparathyroidism: a randomized, crossover trial.
- Ito H1, Ogata H, Yamamoto M, Takahashi K, Shishido K, Takahashi J, Taguchi S, Kinugasa E.
- Clinical nephrology.Clin Nephrol.2009 Jun;71(6):660-8.
- BACKGROUND: Falecalcitriol is a novel vitamin D analog, which has a greater potential to suppress parathyroid hormone (PTH) and a longer half-life. There are few studies to compare clinical effects of oral falecalcitriol treatment with those of intravenous calcitriol treatment.METHODS: Twenty-one pa
- PMID 19473635
- Vitamin D receptor activators.
- Mazzaferro S1, Pasquali M, Conte C, Mandanici G, Muci M, Lavini R.
- The International journal of artificial organs.Int J Artif Organs.2009 Feb;32(2):101-7.
- The fields for clinical employment of vitamin D analogs are growing and under active evaluation in different medical specialties, ranging from dermatology to immunology and oncology. In this review we provide a brief description of the drugs that have been developed more specifically for the treatme
- PMID 19363782
Japanese Journal
- 甲状腺全摘出症例に対するファレカルシトリオールを用いた術後管理
- 塚谷 才明,道岸 隆敏,横山 邦彦,中西 庸介,吉崎 智一
- 頭頸部癌 = Head and neck cancer 38(4), 437-441, 2012-12-25
- NAID 10031170552
- 甲状腺全摘出症例に対するファレカルシトリオールを用いた術後管理
- 塚谷 才明,道岸 隆敏,横山 邦彦,中西 庸介,吉崎 智一
- 頭頸部癌 38(4), 437-441, 2012
- 甲状腺癌に対して甲状腺全摘出,副甲状腺自家移植を行った20症例を対象にファレカルシトリオールを組み込んだプロトコルにて管理した。16例(80%)はプロトコル通り管理可能であった。低カルシウム血症の症状が出現した為,プロトコルを逸脱した症例は4例(20%)であったが速やかにカルシウムを投与することによってテタニーをおこした症例はなかった。全20症例で術後1週間までに血清カルシウム値の良好なコントロー …
- NAID 130004510162
- 久保寺 登
- 有機合成化学協会誌 68(9), 904-910, 2010-09-01
- … Six active vitamin D derivatives (maxacalcitol, calcipotriol, tacalcitol, paricalcitol, doxercalciferol, and falecalcitriol) based on the findings during the third milestone are now commercially available and contributing to current clinical practice. …
- NAID 10026870556
Related Links
- ファレカルシトリオール(Falecalcitriol)の検索ならお薬検索QLife(キューライフ)。お医者さんが処方する処方薬と、薬局で買える市販薬(OTC)、の効果と副作用、写真、添付文書、保管方法等を掲載。商品名だけでなく一般名や剤形、色 ...
- Falecalcitriol(Fulstan; Hornel) is an analog of calcitriol; has a higher potency both in vivo and in vitro systems, and longer duration of action in vivo. ... 25,26-Dihydroxyvitamin D3(25,26-dihydroxycholecalciferol) is a metabolite of vitamin ...
Related Pictures
★リンクテーブル★
[★]
- 英
- falecalcitriol
- 商
- フルスタン、ホーネル、Fulstan