エチドカイン
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/02/20 22:30:25」(JST)
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Etidocaine
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Systematic (IUPAC) name |
N-(2,6-dimethylphenyl)-
2-(ethyl(propyl)amino)butanamide |
Clinical data |
AHFS/Drugs.com |
Micromedex Detailed Consumer Information |
MedlinePlus |
a603026 |
Pregnancy cat. |
B1 (AU) B (US) |
Legal status |
℞-only (US) |
Routes |
Parenteral |
Pharmacokinetic data |
Bioavailability |
n/a |
Metabolism |
Hepatic |
Half-life |
2.5 hours |
Excretion |
Renal |
Identifiers |
CAS number |
36637-18-0 |
ATC code |
N01BB07 |
PubChem |
CID 37497 |
IUPHAR ligand |
2621 |
DrugBank |
n/a |
ChemSpider |
34400 Y |
UNII |
I6CQM0F31V Y |
KEGG |
D04095 Y |
ChEBI |
CHEBI:4904 Y |
ChEMBL |
CHEMBL492 Y |
Chemical data |
Formula |
C17H28N2O |
Mol. mass |
276.42 g/mol |
SMILES
- O=C(Nc1c(C)cccc1C)C(CC)N(CC)CCC
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InChI
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InChI=1S/C17H28N2O/c1-6-12-19(8-3)15(7-2)17(20)18-16-13(4)10-9-11-14(16)5/h9-11,15H,6-8,12H2,1-5H3,(H,18,20) Y
Key:VTUSIVBDOCDNHS-UHFFFAOYSA-N Y
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Y (what is this?) (verify)
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Etidocaine, marketed under the trade name Duranest, is a local anesthetic given by injection during surgical procedures and labor and delivery. Etidocaine has a long duration of activity, and the main disadvantage of using during dentistry is increased bleeding during surgery.
External links
Anesthetics: Local anesthetics - primarily sodium channel blockers (N01B)
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Esters |
Esters of aminobenzoic acid
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- Amylocaine
- Benzocaine
- Butacaine
- Butamben
- Chloroprocaine
- Dimethocaine
- Meprylcaine
- Metabutethaminey
- Metabutoxycaine
- Orthocaine
- Propoxycaine
Insert non-formatted text here
- Procaine (Novocaine)
- Proxymetacaine
- Risocaine
- Tetracaine
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Esters of benzoic acid
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- 3-(p-Fluorobenzoyloxy)tropane
- Cocaine
- Cyclomethycaine
- Hexylcaine
- Piperocaine
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Amides |
- Articaine
- Bupivacaine # /Levobupivacaine/Ropivacaine
- Butanilicaine
- Carticaine
- Dibucaine
- Etidocaine
- Lidocaine #
- Mepivacaine
- Prilocaine
- Trimecaine
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Combinations |
Anesthetic/anesthetic - Lidocaine/prilocaine
Anesthetic/vasoconstrictor - Iontocaine
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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anat (h/r/t/c/b/l/s/a)/phys (r)/devp/prot/nttr/nttm/ntrp
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noco/auto/cong/tumr, sysi/epon, injr
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UpToDate Contents
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English Journal
- Single injection peribulbar anesthesia with a short needle combined with digital compression.
- Riad W, Ahmed N.SourceDepartment of Anaesthesia, King Khaled Eye Specialist Hospital, P.O. Box 7191, Riyadh 11462, Kingdom of Saudi Arabia. waleed_riad@yahoo.com
- Anesthesia and analgesia.Anesth Analg.2008 Nov;107(5):1751-3.
- BACKGROUND: We compare the efficacy of using a 15 mm to the standard 25 mm needle for performing peribulbar blockade.METHODS: Blocks were performed on 150 patients using 15 or 25 mm needle length. Digital compression was applied by the thumb and index finger around the needle hub during injection wi
- PMID 18931243
- Cyclic metabolites: chemical and biological considerations.
- Erve JC.SourceDrug Safety and Metabolism, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA. ERVEJ@wyeth.com
- Current drug metabolism.Curr Drug Metab.2008 Feb;9(2):175-88.
- Metabolism of xenobiotics can sometimes generate cyclic metabolites. Such metabolites are usually the result of intramolecular reactions occurring within a primary or secondary metabolite and this chemistry may lead to unexpected structures. Intramolecular chemistry is often driven by nucleophilic g
- PMID 18288959
Japanese Journal
- Anesthetic efficacy and heart rate effects of the intraosseous injection of 1.5% etidocaine (1:200,000 epinephrine) after an inferior alveolar nerve block
- STABILE P
- Oral Surg Oral Med Oral Pathol Oral Radiol Endod 89, 407-411, 2000
- NAID 30012473856
- Partition coefficients (n-octanol/water) of N-butyl-p-aminobenzoate and other local anesthetics measured by reversed-phase high-performance liquid chromatography
- GROULS R. J. E.,ACKERMAN E. W.,KORSTEN H. H. M.,HELLEBREKERS L. J.,BREIMER D. D.
- Journal of chromatography. B, Biomedical sciences and applications 694(2), 421-425, 1997-07-04
- NAID 10024517525
Related Links
- Etidocaine, marketed under the trade name Duranest, is a local anesthetic given by injection during surgical procedures and labor and delivery. Etidocaine has a long duration of activity, and the main disadvantage of using during ...
Related Pictures
★リンクテーブル★
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- 英
- etidocaine
- 化
- 塩酸エチドカイン etidocaine hydrochloride