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Protective effects of a purified saponin mixture from Astragalus corniculatus Bieb., in vivo hepatotoxicity models.

Vitcheva V1, Simeonova R, Krasteva I, Nikolov S, Mitcheva M.
Phytotherapy research : PTR.Phytother Res.2013 May;27(5):731-6. doi: 10.1002/ptr.4785. Epub 2012 Jul 19.
In this study, the in vivo effects of a purified saponin mixture (PSM), obtained from Astragalus corniculatus Bieb., were investigated using two in vivo hepatotoxicity models based on liver damage caused by paracetamol (PC) and carbon tetrachloride (CCl4 ). The effects of PSM were compared with sily
PMID 22815248

Nifedipine lowers cocaine-induced brain and liver enzyme activity and cocaine urinary excretion in rats.

Vitcheva V1, Simeonova R, Karova D, Mitcheva M.
Arhiv za higijenu rada i toksikologiju.Arh Hig Rada Toksikol.2011 Jun;62(2):131-7. doi: 10.2478/10004-1254-62-2011-2086.
The aim of this study was to see how nifedipine counters the effects of cocaine on hepatic and brain enzymatic activity in rats and whether it affects urinary excretion of cocaine. Male Wistar rats were divided in four groups of six: control, nifedipine group (5 mg kg-1i.p. a day for five days); coc
PMID 21705300

Effect of cytisine on some brain and hepatic biochemical parameters in spontaneously hypertensive rats.

Simeonova R1, Vitcheva V, Mitcheva M.
Interdisciplinary toxicology.Interdiscip Toxicol.2010 Mar;3(1):21-5. doi: 10.2478/v10102-010-0004-4. Epub 2010 Mar 29.
Tobacco smoking is a risk factor for variety of cardio-vascular diseases, such as hypertension, myocardial infarction, stroke and many others. It is of great importance for hypertensive patients to stop smoking. One of the medicines widely used for smoking cessation in Bulgaria is the original Bulga
PMID 21217867

Endotoxin- and Inflammation-Induced Depression of the Hepatic Drug Metabolism in Rats.

Ishikawa Masaaki,Sasaki Kenroh,Nishimura Kimiko,Takayanagi Yoshio,Sasaki Ken-ichi
The Japanese Journal of Pharmacology 55(4), 551-554, 1991
… Carrageenan-induced inflammation and exposure to endotoxin considerably decreased the content of cytochrome P-450 and activities of ethylmorphine N-demethylase and meperidine N-demethylase, but did not decrease the activities of aniline hydroxylase or NADPH-cytochrome c reductase, compared with the respective activities in rats treated with carrageenan alone. …
NAID 130000833082

Comparison of effects of acetaminophen on liver microsomal drug metabolism and lipid peroxidation in rats and mice.

Aikawa Kazuo,Satoh Tetsuo,Kitagawa Haruo
The Japanese Journal of Pharmacology 28(3), 485-491, 1978
… AAP was found to inhibit ethylmorphine N-demethylase activity in the presence of NADPH and this inhibition of the enzyme was due to decrease in cytochrome P-450 content, but not due to change in lipid peroxidation in liver microsomes. … Kinetical data showed that AAP administration had no effect on Km values of ethylmorphine N-demethylase, however, a decrease in the Vmax values was seen in rats and mice. …
NAID 130000839399

Enhancement in vivo of drug oxidations following administration of benzphetamine, acetone, metyrapone and dimethylsulfoxide.

Kitada Mitsukazu,Kamataki Tetsuya,Kitagawa Haruo
The Japanese Journal of Pharmacology 28(2), 213-221, 1978
… Activities for aniline hydroxylation and phenacetin O-deethylation were increased while ethylmorphine and benzphetamine N-demethylations were unchanged by the single administration of acetone, metyrapone or dimethylsulfoxide. …
NAID 130000839324