English Journal

Prophylactic effect of egualen sodium, a stable azulene derivative, on gastrointestinal damage induced by ischemia/reperfusion, double antiplatelet therapy and loxoprofen in rats.

Amagase K1, Yoshida Y, Hara D, Murakami T, Takeuchi K.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.J Physiol Pharmacol.2013 Feb;64(1):65-75.
We examined the effect of egualen, a stable azulene derivative, against gastric damage induced by ischemia/reperfusion (I/R), gastric bleeding induced by double antiplatelet therapy with aspirin (ASA) plus clopidogrel, and small intestinal damage generated by loxoprofen, and investigated the possibl
PMID 23568973

A ring expansion-annulation strategy for the synthesis of substituted azulenes. Preparation and Suzuki coupling reactions of 1-azulenyl triflates.

Kane JL Jr1, Shea KM, Crombie AL, Danheiser RL.
Organic letters.Org Lett.2001 Apr 5;3(7):1081-4.
[structure: see text]. A new strategy for the synthesis of substituted azulenes is reported, based on the reaction of beta'-bromo-alpha-diazo ketones with rhodium carboxylates. The key transformation involves intramolecular addition of a rhodium carbenoid to an arene pi-bond, electrocyclic ring open
PMID 11277800

Inhibitory effect of egualen sodium: a new stable derivative of azulene on histamine release from mast cell-like cells in the stomach.

Akagi M1, Matsui N, Mochizuki S, Tasaka K.
Pharmacology.Pharmacology.2001;63(4):203-9.
We studied the inhibitory effect of egualen sodium (ES) (sodium 3-ethyl-7-isopropyl-1-azulenesulfonate 1/3 hydrate, KT1-32), a new derivative and more stable compound than azulene, on histamine release from the mucosal histaminocytes and elucidated the mechanism for this action. ES prevented the his
PMID 11729358