関: dipivefrin、dipivefrin hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/04/03 11:27:00」(JST)

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Dipivefrine is a prodrug of epinephrine used to treat glaucoma. It is available as ophthalmic solution. It causes vasoconstriction, decreased aqueous humor production, and decreases intraoccular pressure. It is converted to epinephrine upon penetration of the cornea.

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1. 原発性乳児緑内障 primary infantile glaucoma
2. 陣痛開始時および分娩時（経腟器械分娩も含む）の区域麻酔 neuraxial analgesia for labor and delivery including instrumented delivery

English Journal

Comparison of chiral electrophoretic separation methods for phenethylamines and application on impurity analysis.

Borst C1, Holzgrabe U.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2010 Dec 15;53(5):1201-9. doi: 10.1016/j.jpba.2010.06.025. Epub 2010 Jun 30.
A chiral microemulsion electrokinetic chromatography method has been developed for the separation of the enantiomers of the phenethylamines ephedrine, N-methylephedrine, norephedrine, pseudoephedrine, adrenaline (epinephrine), 2-amino-1-phenylethanol, diethylnorephedrine, and 2-(dibutylamino)-1-phen
PMID 20638811

Pupillary autonomic dysfunction in multiple system atrophy and Parkinson's disease: an assessment by eye-drop tests.

Yamashita F1, Hirayama M, Nakamura T, Takamori M, Hori N, Uchida K, Hama T, Sobue G.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society.Clin Auton Res.2010 Jun;20(3):191-7. doi: 10.1007/s10286-009-0051-0. Epub 2010 Feb 3.
PURPOSE: To compare pupillary autonomic dysfunction in multiple system atrophy (MSA) and Parkinson's disease (PD).METHODS: We administered eye-drop tests to 40 MSA patients, 40 PD patients with similar disease duration, and 20 age-matched healthy controls. Pupillary supersensitivity to a parasympath
PMID 20127386

Pupillary supersensitivity and visual disturbance in Parkinson's disease.

Hori N1, Takamori M, Hirayama M, Watanabe H, Nakamura T, Yamashita F, Ito H, Mabuchi N, Sobue G.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society.Clin Auton Res.2008 Feb;18(1):20-7. doi: 10.1007/s10286-008-0453-4. Epub 2008 Feb 11.
This study evaluated pupillary postganglionic autonomic dysfunction and its relationship to visual disturbance in idiopathic Parkinson's disease (PD). Pupillary sensitivity was examined in relation to a parasympathomimetic agent [0.05% pilocarpine hydrochloride (PL)] and to a sympathomimetic agent [
PMID 18265941

Japanese Journal

塩酸ドルゾラミド (トルソプト点眼液) 点眼用炭酸脱水酵素阻害薬の薬理作用と臨床効果

小林正彦,内藤恭三
日本薬理学雑誌 115(6), 323-328, 2000-06-01
… Dorzolamide was as effective as pilocarpine or dipivefrine as an adjunctive therapy in patients receiving β-adrenergic antagonists. …
NAID 10005706182

塩酸ジプベフリンの眼循環に対する影響第1報 : 正常人での網膜中心動脈血流速度の検討

田中佳秋,溝上國義
日本眼科紀要 = Folia ophthalmologica Japonica 47(6), 752-755, 1996-06-28
NAID 10009723488

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リンク元	「ジピベフリン」「dipivefrin hydrochloride」
関連記事	「dipivefrin」

「ジピベフリン」

Dipivefrine
Systematic (IUPAC) name
	[2-(2,2-dimethylpropanoyloxy)-4- (1-hydroxy-2-methylamino-ethyl)- phenyl] 2,2-dimethylpropanoate
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a686005
Pregnancy cat.	B (US)
Legal status	?
Identifiers
CAS number	52365-63-6
ATC code	S01EA02
PubChem	CID 3105
DrugBank	DB00449
ChemSpider	2994
UNII	8Q1PVL543G
KEGG	D02349
ChEBI	CHEBI:4646
ChEMBL	CHEMBL1201262
Chemical data
Formula	C19H29NO5
Mol. mass	351.437 g/mol
	SMILES O=C(Oc1cc(ccc1OC(=O)C(C)(C)C)C(O)CNC)C(C)(C)C;
	InChI InChI=1S/C19H29NO5/c1-18(2,3)16(22)24-14-9-8-12(13(21)11-20-7)10-15(14)25-17(23)19(4,5)6/h8-10,13,20-21H,11H2,1-7H3 ; Key:OCUJLLGVOUDECM-UHFFFAOYSA-N ;
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