関: dipivefrin hydrochloride、dipivefrine

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/08 01:09:03」(JST)

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Dipivefrin (trade name Propine) is a prodrug of epinephrine, and is used to treat open-angle glaucoma.^[1] It is available as a 0.1% ophthalmic solution.

Mechanism of action

The drug when applied over the cornea, penetrates it and is then hydrolysed to epinephrine by the esterases. It increases uveo-scleral outflow and also reduces aqueous formation (an α₁ and α₂ mediated action), thus reducing the intraocular pressure. It also increases the hydraulic conductivity of trabecular filtering cells (a β₂ mediated action). It is preferred to epinephrine because it is longer acting, more consistent in its action and has better ocular tolerance.^[1]

References

^ ^a ^b KD Tripari MD. Essentials of Medical Pharmacology (5 ed.). Jaypee Brothers Medical Publishers(P) Ltd. p. 88. ISBN 81-8061-187-6.

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English Journal

Effects of topical adrenergic agents on prostaglandin E2-induced aqueous flare and intraocular pressure elevation in pigmented rabbits.

Nakamura-Shibasaki M1, Latief MA2, Ko JA1, Funaishi K1, Kiuchi Y3.
Japanese journal of ophthalmology.Jpn J Ophthalmol.2016 Mar;60(2):95-102. doi: 10.1007/s10384-016-0428-2. Epub 2016 Feb 2.
PURPOSE: To evaluate the effects of signals through adrenergic receptors on the changes in the aqueous flare and intraocular pressure (IOP) induced by topical prostaglandin E2 (PGE2) in pigmented rabbits.METHODS: Adrenergic agents were applied topically to pigmented Dutch rabbits, and PGE2 was then
PMID 26832333

Bidirectional Modulation of Alcohol-Associated Memory Reconsolidation through Manipulation of Adrenergic Signaling.

Schramm MJ1, Everitt BJ1, Milton AL1.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.Neuropsychopharmacology.2016 Mar;41(4):1103-11. doi: 10.1038/npp.2015.248. Epub 2015 Aug 17.
Alcohol addiction is a problem of great societal concern, for which there is scope to improve current treatments. One potential new treatment for alcohol addiction is based on disrupting the reconsolidation of the maladaptive Pavlovian memories that can precipitate relapse to drug-seeking behavior.
PMID 26279079

Update on the role of alpha-agonists in glaucoma management.

Arthur S1, Cantor LB.
Experimental eye research.Exp Eye Res.2011 Sep;93(3):271-83. doi: 10.1016/j.exer.2011.04.002. Epub 2011 Apr 20.
Glaucoma is the second most common cause of world blindness (following cataract) with estimated cases reaching 79.6 million by 2020. Although the etiology of glaucoma is multi-factorial, intraocular pressure (IOP) is the only modifiable factor in glaucoma management proven to alter the natural cours
PMID 21524649

Japanese Journal

症例報告ジピベフリンの点眼が有効であった眼瞼下垂の1例

北川清隆,柳沢秀一郎,山田哲也 [他]
富山大学医学会誌 17(1), 27-29, 2006
NAID 40015793690

原発開放隅角緑内障および高眼圧症に対する塩酸ブナゾシン点眼液とマレイン酸チモロール点眼液の併用効果の検討 : 塩酸ジピベフリン点眼液との比較

東郁郎,北澤克明,塚原重雄,高瀬正彌,米虫節夫
あたらしい眼科 = Journal of the eye 19(2), 261-266, 2002-02-28
NAID 10017003508

「ジピベフリン」

Dipivefrine
Systematic (IUPAC) name
	[2-(2,2-dimethylpropanoyloxy)-4- (1-hydroxy-2-methylamino-ethyl)- phenyl] 2,2-dimethylpropanoate
Clinical data
Trade names	Propine
AHFS/Drugs.com	International Drug Names
MedlinePlus	a686005
Pregnancy; category	US: B (No risk in non-human studies); ;
Identifiers
CAS Number	52365-63-6
ATC code	S01EA02 (WHO)
PubChem	CID 3105
IUPHAR/BPS	7166
DrugBank	DB00449
ChemSpider	2994
UNII	8Q1PVL543G
KEGG	D02349
ChEBI	CHEBI:4646
ChEMBL	CHEMBL1201262
Chemical data
Formula	C19H29NO5
Molar mass	351.437 g/mol
	SMILES O=C(Oc1cc(ccc1OC(=O)C(C)(C)C)C(O)CNC)C(C)(C)C ;
	InChI InChI=1S/C19H29NO5/c1-18(2,3)16(22)24-14-9-8-12(13(21)11-20-7)10-15(14)25-17(23)19(4,5)6/h8-10,13,20-21H,11H2,1-7H3 ; Key:OCUJLLGVOUDECM-UHFFFAOYSA-N ;
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