UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 皮膚疣贅（尋常性疣贅、足底疣贅、扁平疣贅）cutaneous warts common plantar and flat warts [show details]
…Limited data suggest that contact allergens, such as squaric acid dibutylester (SADBE), dinitrochlorobenzene (DNCB), and diphenylcyclopropenone (DPCP), can be effective treatments. An advantage of topical … response to skin testing with at least one of the above antigens randomly assigned patients to receive one of four treatments injected into a single wart: 0.3 mL of an antigen that produced a skin test response…
2. 薬物過敏症：分類および臨床的特徴drug hypersensitivity classification and clinical features [show details]
…different clinical pictures of drug allergy (eg, contact dermatitis to 1-chloro-2,4-dinitrobenzene (DNCB), IgE-mediated anaphylaxis to penicillin). The different types of immunologic drug reactions are described…
3. ロボミコーシスlobomycosis [show details]
…lobomycosis is also suggested by studies that utilized skin tests to assess immunologic function. Frequent absence of positive reactions to dinitrochlorobenzene sensitization, and reduced likelihood for positive…
4. アレルギー疾患のための皮膚試験の概要overview of skin testing for allergic disease [show details]
…food, and medication allergies. Skin testing is an important element in the diagnosis of IgE-mediated allergy. This topic review will discuss general principles of skin testing used in the diagnosis of IgE-mediated …
5. ペニシリンの皮膚試験penicillin skin testing [show details]
…reported since modern skin testing methods have been in use . Skin testing has been safely performed in pregnant women , as well as in critically-ill patients . Penicillin skin testing results are obtained …

English Journal

Some non-sensitizers upregulate CD54 expression by activation of the NLRP3 inflammasome in THP-1 cells.

Mitachi T, Kouzui M, Maruyama R, Yamashita K, Ogata S, Kojima H, Itagaki H.
The Journal of toxicological sciences. 2019 ;44(3)213-224.
The human cell line activation test (h-CLAT) is a skin sensitization test that measures the expression of cell surface proteins CD86 and CD54 to evaluate the skin sensitization potential of test chemicals. However, some skin irritants have been reported to induce dramatically high CD54 expression le
PMID 30842373

Prednisolone-loaded coatable polyvinyl alcohol/alginate hydrogel for the treatment of atopic dermatitis.

Lee HR, Kim TH, Oh SH, Lee JH.
Journal of biomaterials science. Polymer edition. 2018 09;29(13)1612-1624.
Atopic dermatitis (AD) is a chronic inflammatory skin disease resulting pruritic, erythema, edema, excoriation, and thickening of the skin, and thus leads to significant impairment in the patient's life. The objective of this study is to develop a steroid drug [prednisolone (PS)]-loaded coatable hyd
PMID 29764304

Lymphocyte surface markers and cytokines are suitable for detection and potency assessment of skin-sensitizing chemicals in an in vitro model of allergic contact dermatitis: the LCSA-ly.

Frombach J, Sonnenburg A, Krapohl BD, Zuberbier T, Peiser M, Stahlmann R, Schreiner M.
Archives of toxicology. 2018 Apr;92(4)1495-1505.
Allergic contact dermatitis is a widespread health disorder and occupational skin disease. Hence, screening for contact-sensitizing chemicals is highly relevant to toxicology, dermatology, and occupational medicine. The use of animal tests for this purpose is constrained by ethical considerations, n
PMID 29380012

Japanese Journal

Some non-sensitizers upregulate CD54 expression by activation of the NLRP3 inflammasome in THP-1 cells

Mitachi Takafumi,Kouzui Mai,Maruyama Ryo,Yamashita Kunihiko,Ogata Shinichi,Kojima Hajime,Itagaki Hiroshi
Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 44(3), 213-224, 2019
… The human cell line activation test (h-CLAT) is a skin sensitization test that measures the expression of cell surface proteins CD86 and CD54 to evaluate the skin sensitization potential of test chemicals. … However, some skin irritants have been reported to induce dramatically high CD54 expression leading to false-positive h-CLAT results. …
NAID 130007609228

Acidic conditions induce the suppression of CD86 and CD54 expression in THP-1 cells

Mitachi Takafumi,Mezaki Minori,Yamashita Kunihiko,Itagaki Hiroshi
Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 43(5), 299-309, 2018
… Current assays are based on the expression of cell surface markers, such as CD86 and CD54, which are associated with the activation of dendritic cells, in skin sensitization tests. … In this study, we investigated the relationship between extracellular pH and the expression of the skin sensitization test human cell line activation test (h-CLAT) markers CD86 and CD54. …
NAID 130006733283

in vitro皮膚感作性試験における酸性物質の影響

目﨑美紀,三田地隆史,板垣宏
日本毒性学会学術年会 44.1(0), P-28, 2017
… 現在、in vitro皮膚感作性試験としてhuman Cell Line Activation Test (h-CLAT)などが開発されている。 … 被験物質として、感作性物質である2,4-Dinitrochlorobenzene(DNCB) 3.6 µg/mL、非感作性物質であるIsopropanol(IP) 3900 µg/mLを用いた。 …
NAID 130006582156