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[How the various substrates activate the process of enzymatic hydrolysis by different cholinesterases].

Basova NE, Rozengrart EV.AbstractKinetic analysis of the activating effect of substrate on the cholinesterase catalysis is performed. There are determined values of coefficient of activation A in the pH zone 5.0-7.5 for the process of hydrolysis of acetylcholine, indophenylacetate (IPA), and 2,6-dichlorophenolindophenylacetate (DIPA) by cholinesterase (ChE) of horse blood serum, as well as of IPA and DIPA by ChE of optical ganglia of the Pacific squid Todarodes pacificus. The phenomenon of activation has not been revealed at hydrolysis of phenylacetate by the horse blood serum ChE. The conclusion is made that the cause of the activating effect of substrate on the process of enzymatic hydrolysis by ChEs of different origin is the presence of the onium grouping in the structure of substrates.
Zhurnal evoliutsionno? biokhimii i fiziologii.Zh Evol Biokhim Fiziol.2010 Nov-Dec;46(6):485-8.
Kinetic analysis of the activating effect of substrate on the cholinesterase catalysis is performed. There are determined values of coefficient of activation A in the pH zone 5.0-7.5 for the process of hydrolysis of acetylcholine, indophenylacetate (IPA), and 2,6-dichlorophenolindophenylacetate (DIP
PMID 21268878

Formula weight prediction by internal reference diffusion-ordered NMR spectroscopy (DOSY).

Li D, Kagan G, Hopson R, Williard PG.SourceDepartment of Chemistry, Brown University, Providence, Rhode Island 02912, USA.
Journal of the American Chemical Society.J Am Chem Soc.2009 Apr 22;131(15):5627-34.
Formula weight (FW) information is important to characterize the composition, aggregation number, and solvation state of reactive intermediates and organometallic complexes. We describe an internal reference correlated DOSY method for calculating the FW of unknown species in different solvents with
PMID 19323518

Diisopropylamine Dichloroacetate, a Novel Pyruvate Dehydrogenase Kinase 4 Inhibitor, as a Potential Therapeutic Agent for Metabolic Disorders and Multiorgan Failure in Severe Influenza