dihydrofolic acid

ジヒドロ葉酸

同

(FH2

WordNet

1. street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
2. any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
3. having the characteristics of an acid; "an acid reaction"

PrepTutorEJDIC

1. 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/05/12 12:25:19」(JST)

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[Wiki en表示]

Dihydrofolic acid
IUPAC name N-(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
Other names H2folate, DH
Identifiers
CAS number	4033-27-6
PubChem	98792
ChemSpider	89228 Y
MeSH	dihydrofolate
ChEBI	CHEBI:15633 Y
ChEMBL	CHEMBL46294 Y
Jmol-3D images	Image 1
SMILES O=C(O)[C@@H](NC(=O)c1ccc(cc1)NCC/2=N/C=3C(=O)\N=C(/NC=3NC\2)N)CCC(=O)O
InChI InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1 Y Key: OZRNSSUDZOLUSN-LBPRGKRZSA-N Y InChI=1/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1 Key: OZRNSSUDZOLUSN-LBPRGKRZBB
Properties
Molecular formula	C19H21N7O6
Molar mass	443.414 g/mol
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Dihydrofolic acid (dihydrofolate, vitamin B₉) is a folic acid derivative which is converted to tetrahydrofolic acid by dihydrofolate reductase. Since tetrahydrofolate is needed to make both purines and pyrimidines, which are building blocks of DNA and RNA, dihydrofolate reductase is targeted by various drugs to prevent nucleic acid synthesis.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

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Fluorouracil (5-FU) Activity edit

References

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 尿酸のバランス uric acid balance
• 2. 胎児の酸塩基の生理学 fetal acid base physiology
• 3. 妊娠中の葉酸補充 folic acid supplementation in pregnancy
• 4. ポルフィリン症：概要 porphyrias an overview
• 5. クローン病における免疫調節療法 immunomodulator therapy in crohn disease

English Journal

• Identification and dynamic modeling of biomarkers for bacterial uptake and effect of sulfonamide antimicrobials.

• Richter MK, Focks A, Siegfried B, Rentsch D, Krauss M, Schwarzenbach RP, Hollender J.SourceEawag, Swiss Federal Institute of Aquatic Science and Technology, Überlandstrasse 133, 8600 Dübendorf, Switzerland.
• Environmental pollution (Barking, Essex : 1987).Environ Pollut.2013 Jan;172:208-15. doi: 10.1016/j.envpol.2012.09.011. Epub 2012 Oct 11.
• The effects of sulfathiazole (STA) on Escherichia coli with glucose as a growth substrate was investigated to elucidate the effect-based reaction of sulfonamides in bacteria and to identify biomarkers for bacterial uptake and effect. The predominant metabolite was identified as pterine-sulfathiazole
• PMID 23063996

• Multiple point action mechanism of valproic acid-teratogenicity alleviated by folic acid, vitamin C, and N-acetylcysteine in chicken embryo model.

• Hsieh CL, Wang HE, Tsai WJ, Peng CC, Peng RY.SourceGraduate Institute of Biotechnology, Changhua University of Education, Jin-De Campus, 1 Jin-De Rd., Changhua 50007, Taiwan.
• Toxicology.Toxicology.2012 Jan 27;291(1-3):32-42. doi: 10.1016/j.tox.2011.10.015. Epub 2011 Oct 25.
• The teratogenicity of antiepilepsy drug valproic acid (VPA) mostly is found in genetic and somatic levels, causing teratogenesis involving neurotubular defects (NTDs), anencephaly, lumbosacral meningomyelocele, and leg dysfunction due to spina bifida aperta. A diversity of nutraceutics have been tri
• PMID 22051200

• Effect of genetic polymorphisms in the folate pathway on methotrexate therapy in rheumatic diseases.

• Stamp LK, Roberts RL.SourceDepartment of Biochemistry, University of Otago, Dunedin 9054, New Zealand. lisa.stamp@cdhb.govt.nz
• Pharmacogenomics.Pharmacogenomics.2011 Oct;12(10):1449-63. doi: 10.2217/pgs.11.86.
• Methotrexate (MTX) is the first-line treatment for rheumatoid arthritis and is frequently used in the management of other forms of inflammatory arthritis. It is currently challenging to predict which patients will achieve adequate disease control and which patients will develop adverse effects while
• PMID 22008049

Japanese Journal

• 7-Hydro-8-methylpteroylglutamylglutamic acid, a new anti-folate from an actinomycete. Fermentation, isolation, structure and biological activity.:FERMENTATION, ISOLATION, STRUCTURE AND BIOLOGICAL ACTIVITY

• MURATA MASATSUNE,TANAKA HARUO,OMURA SATOSHI
• The Journal of Antibiotics 40(3), 251-257, 1987
• … A new anti-folate, 7-hydro-8-methylpteroylglutamylglutamic acid, was isolated from the culture broth of a soil actinomycete. … The antibiotic inhibited the growth of Enterococcus faecium which requires folic acid. … The inhibitory action was reversed by thymidine or excess amounts of folate-related compounds such as pteroic acid, folic acid, dihydrofolic acid and leucovorin. …
• NAID 130003501209

• Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates

• ALLEGRA C. J.
• Proc. Natl Acad. Sci. USA 82, 4881, 1985
• NAID 30016277775

• Structure- Activity Relationships of Folate Derivatives as Inhibitors of Xanthine Oxidase in Vitro

• YAMAMOTO Itaru,OKIMURA Tsutomu,KASAHARA Etsuko,NISHIOKA Kusuki,MIKANAGI Kiyonobu
• Uric acid
• … have reconfirmed the inhibitory effect of folic acid on this enzyme N<SUP>10</SUP>-Formyl folic acid was even stronger inhibitor than folic acid.Reduced forms of folate and its derivatives, namely N<SUP>5</SUP>, N<SUP>10</SUP>-methenyltetrahydrofolic acid, tetrahydrofolic acid and dihydrofolic acid were also effective inhibitors of this enzyme, indicating that …
• NAID 130004596466

Related Links

• Dihydrofolic acid | Define Dihydrofolic acid at Dictionary.com

Dihydrofolic acid definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now! Thesaurus Translator Reference Word of the Day Blog Slideshows Apps by Dictionary Log Out ...

• dihydrofolic acid - definition of dihydrofolic acid by Medical ...

forum Join the Word of the Day Mailing List For webmasters TheFreeDictionary Google Bing? Word / Article Starts with Ends with Text ... dihydrofolic acid /di·hy·dro·fol·ic ac·id/ (-fo´lik) any of the folic acids in which the bicyclic ...

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