関: diabetic microangiopathy、diabetic vascular complication、diabetic vascular disease

WordNet

suffering from diabetes
someone who has diabetes
of or relating to or causing diabetes
any disease of the blood vessels or lymph ducts

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糖尿病の / 糖尿病患者

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/06/14 14:59:17」(JST)

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Diabetic angiopathy is a form of angiopathy associated with diabetes mellitus. While not exclusive, the two most common forms are Diabetic retinopathy and Diabetic nephropathy, whose pathophysiologies are largely identical.

Pathophysiology[edit]

As insulin is required for glucose uptake, hyperglycemia in diabetes mellitus does not result in a net increase in intracellular glucose in most cells. However, chronic dysregulated blood glucose in diabetes is toxic to cells of the vascular endothelium which passively assimilate glucose. That is, cells in which insulin is not required for intercellular transport of glucose, most-notably the pericytes of the microvasculature. In addition to direct glucose-induced damage by (e.g.) glycation, pericytes express enzymes which convert glucose into osmologically-active metabolites such as sorbitol leading to hypertonic cell lysis.

Over time, pericyte death may result in reduced capillary integrity; subsequently, there is leaking of albumin and other proteins into fluid compartments. The glomeruli of the kidneys are especially sensitive - see diabetic nephropathy - where protein leakage caused by late-stage angiopathy results in diagnostic proteinuria and eventually renal failure. In diabetic retinopathy the end-result is often blindness due to irreversible retinal damage.

Prognosis and complications[edit]

Diabetes mellitus is the most common cause of adult kidney failure worldwide. It also the most common cause of amputation in the US, usually toes and feet, often as a result of gangrene, and almost always as a result of peripheral vascular disease. Retinal damage (from microangiopathy) makes it the most common cause of blindness among non-elderly adults in the US.

Prognosis is generally poor for all forms of Diabetic angiopathy, as symptomatology is tied to the advancement of the underlying pathology i.e. the early-stage patient displays either non-specific symptoms or none at all.

"Diabetic dermopathy" is a manifestation of diabetic angiopathy. It is often found on the shin.

There is also Neuropathy; also associated with diabetes mellitus; type 1 and 2.

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1. 2型糖尿病における血糖コントロールおよび血管合併症 glycemic control and vascular complications in type 2 diabetes mellitus
2. 糖尿病性神経障害の治療 treatment of diabetic neuropathy
3. 1型糖尿病における血糖コントロールおよび血管合併症 glycemic control and vascular complications in type 1 diabetes mellitus
4. 1型糖尿病の小児および青年における運動の管理 management of exercise for children and adolescents with type 1 diabetes mellitus
5. 成人における糖尿病に対する治療の概要 overview of medical care in adults with diabetes mellitus

English Journal

Fibrate use in the United States and Canada.

Lim LS, Wong TY.
JAMA : the journal of the American Medical Association.JAMA.2011 Jul 13;306(2):157-8; author reply 158-9.
PMID 21750289

Aspirin resistance and platelet turnover: A 25-year old issue.

Di Minno G.SourceDepartment of Clinical and Experimental Medicine, Regional Reference Centre for Coagulation Disorders, Federico II University, Naples, Italy.
Nutrition, metabolism, and cardiovascular diseases : NMCD.Nutr Metab Cardiovasc Dis.2011 Jul 9. [Epub ahead of print]
The evidence of an incomplete inhibition of platelet function by aspirin, despite therapeutic doses of the drug proved to be clinically effective are employed, was first reported in the '80s, in the frame of studies devoted to platelet turnover. Because inhibition of platelet aggregation by aspirin
PMID 21745731